Primary cicatricial alopecia profile in Chilean population: a retrospective study

Mardones, Francisco; Valenzuela, Karen

doi:10.1111/ijd.15942

Cited by 1 publication

(2 citation statements)

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“…In other richly pigmented skin populations, DLE most commonly biopsied CA. 4–6,9,10,14,15 In our population, it is not. Again, this divergence may result from our Afro-Caribbean majority population where CCCA is evidently a relatively prevalent disease.…”

Section: Discussionmentioning

confidence: 67%

“…This contrasts with other non-Black but richly pigmented skin populations and White-predominant populations where DLE and LPP are the most commonly biopsied CAs, respectively. [4][5][6]9,10,14,15 FD and chronic TA (including MFA component diagnoses) were the second most common. Although chronic TA was unsurprising given common hairstyling practices in Afro-Caribbean populations, the high proportion of FD was unexpected.…”

Section: Discussionmentioning

confidence: 99%

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Histopathologic Spectrum of Alopecias Seen in a Jamaican Setting

Ho,

Collie,

Spencer

2023

The American Journal of Dermatopathology

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Alopecia is common in Jamaican, primarily Afro-Caribbean patients. We performed a retrospective review examining the histopathologic alopecia diagnoses over ∼5 years. Requisition forms and pathology reports were assessed. Demographic/clinical/technical/diagnostic and pathologic findings of chronicity/severity data were recorded. Three hundred thirty-eight biopsies were included. The majority were 4 mm punches, grossed horizontally. The F:M ratio was 4.8:1, mean age = 42.7 years, and mean duration of alopecia = 5.1 years. Cicatricial alopecias (CAs) predominated over non-CAs (NCAs). The top 10 diagnoses were central centrifugal CA (21.9%), folliculitis decalvans (10.9%), multifactorial alopecias (10.1%), pattern hair loss (8%), lichen planopilaris (7.1%), alopecia areata (6.2%), discoid lupus erythematosus (6.2%), nonclassifiable lymphocytic scarring alopecias (5.6%), frontal fibrosing alopecia (5.3%), and nonspecific NCAs (5%). This contrasted with other richly pigmented populations where discoid lupus erythematosus predominates. Other interesting findings included relatively frequent folliculitis decalvans and lichen planus pigmentosus in 40.9% of frontal fibrosing alopecia cases. Scarring/nonscarring clinicopathologic congruence occurred in 83.4%. Regarding histopathologic features of severity/chronicity, CAs had markedly decreased hair counts. Perifollicular fibrosis affecting retained hairs occurred in 75% of CAs, moderate to severe in >50% of these. Approximately 50% of NCA samples demonstrated advanced miniaturization (T:V ratio <2:1). In our study, relatively young women with chronic hair loss and CA are most frequently biopsied. Central centrifugal CA is the most common diagnosis. Local features of chronic/severe disease are seen microscopically. Clinical impression of scarring/nonscarring correlates well with histopathology.

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Section: Discussionmentioning

confidence: 67%