Primary cicatricial alopecia

Bolduc, Chantal; Sperling, Leonard C.; Shapiro, Jerry

doi:10.1016/j.jaad.2014.09.058

Cited by 101 publications

(97 citation statements)

References 232 publications

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“…It is important to know that although some regrowth may rarely occur, it is not the aim of treatment, and goals must be discussed with the patients so that their expectations are realistic [39]. However, treatment for all the types of PSA can be very difficult because there are no consistent markers to measure the progress of the disorder [18].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical improvement is commonly observed after 4-8 weeks, while the maximum therapeutic effect is not seen until after several months. Although we have no experience in combining different antimalarials, such use is described in the literature [39]; it would have a synergic effect, for cases that do not respond to the full hydroxychloroquine dosage (200-400 mg/day) for 3-6 months. Retinoids are generally used in patients presenting antimalarial resistance.…”

Section: Discussionmentioning

confidence: 99%

“…With respect to topical minoxidil, there is no evidence of its efficacy in PSA, nor is the exact mechanism by which it would act in this type of pathologies known. Nonetheless, in our experience, these patients benefit from its continued use; this may be associated with a hair regrowth of the remaining follicles [39], or, in some cases, this is probably due to the presence of a certain degree of concomitant androgenetic alopecia. Other authors also agree that using a topical 5% minoxidil solution gives good results.…”

Section: Discussionmentioning

confidence: 99%

“…Other authors also agree that using a topical 5% minoxidil solution gives good results. In severe and more extensive cases, camouflage options should be provided [39]. …”

Section: Discussionmentioning

confidence: 99%

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Primary Scarring Alopecia: Clinical-Pathological Review of 72 Cases and Review of the Literature

Villablanca

Fischer

García-García

et al. 2017

Skin Appendage Disord

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Purpose of the Study: To analyze the epidemiologic, demographic, clinical, and histological characteristics of primary scarring alopecia (PSA) cases diagnosed over a 7-year period at the Department of Dermatology, Hospital Clinic, Barcelona, Spain. Procedures: Seventy-two patients diagnosed with PSA between 2006 and 2012 were included. Age, sex, ethnic group, clinical pattern, predominant histological infiltrate, final clinical diagnosis, time of onset, treatments used, and clinical evolution were evaluated and correlated. Results: The ethnic groups were distributed as follows: 93% European-Caucasian, 5% Mestizo-American, 1% oriental, and 1% Afro-American. Most cases were females (71%), and mean age was 51 ± 6 years. The follicular pattern was the most common, and the predominant inflammatory infiltrate was lymphocytic. Lichen planopilaris and frontal fibrosing alopecia were the main diagnoses. When correlating clinical aspects and histopathology, lymphocytic PSAs had a subacute onset and resulted in a nonchanging, more stable form, while neutrophilic PSAs had a more acute onset with an evolution of acute outbreaks. PSAs in a late stage with an absent/mild infiltrate had a subclinical onset and a slowly progressive or stable evolution. Conclusions: The PSAs are severe trichological conditions. Their high clinical and histopathological variability make them a diagnostic and therapeutic challenge. Message of the Paper: Knowing the clinical and histopathological aspects of PSAs should be of crucial importance to the dermatologist.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Other authors also agree that using a topical 5% minoxidil solution gives good results. In severe and more extensive cases, camouflage options should be provided [39]. …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Scarring Alopecia: Clinical-Pathological Review of 72 Cases and Review of the Literature

Villablanca

Fischer

García-García

et al. 2017

Skin Appendage Disord

View full text Add to dashboard Cite

show abstract

“…It is a valuable tool to distinguish scarring from non-scarring alopecias and may also help the physician to select the best biopsy site in doubtful cases [1,2,3,4]. …”

Section: Tablementioning

confidence: 99%