Primary choroidal and cutaneous melanomas, bilateral choroidal melanomas, and familial occurrence of melanomas.

Oosterhuis, J. A.; Went, L. N.; Lynch, Henry T.

doi:10.1136/bjo.66.4.230

Cited by 62 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the Netherlands, a relation has been reported between the occurrence of ocular melanoma and skin melanoma in familial atypical multiple mole syndrome (FAMMM), also called dysplastic nevus syndrome [9,10]. We do not know whether B40 is associated with this syndrome, but such an association is not likely since no linkage between HLA and the inheritance of the FAMMM syndrome has been demonstrated [11].…”

Section: Discussionmentioning

confidence: 96%

Possible relation between HLA and ABO type and prognosis of uveal melanoma

et al. 1992

View full text Add to dashboard Cite

Not only local parameters but also genetic determinants like the HLA genes may play a role in the development and clinical behavior of malignant tumors. In skin melanoma the presence of HLA-B40 is associated with a poor prognosis. We tested the hypothesis that the clinical behavior of uveal melanoma is influenced by the HLA type of the patient. The HLA types of 44 patients with uveal melanoma had been determined before operation with a view to using the cornea of the enucleated eye for an HLA-matched corneal transplantation. We compared the ABO and HLA types of the patients with the development of metastases and with the ten-year patient survival. An association was observed between the presence of HLA-B40 and death due to metastasis of uveal melanoma. We conclude that the HLA type of the patient may influence the clinical behavior not only of skin melanoma but also of uveal melanoma.

show abstract

Section: Discussionmentioning

confidence: 96%

Possible relation between HLA and ABO type and prognosis of uveal melanoma

et al. 1992

View full text Add to dashboard Cite

show abstract

“…Depending on the location and the size of the tumor, reported cases were treated by bilateral beta irradiation (Lommatzch et al 1981), enucleation and plaque brachytherapy (Ascaso et al 1996), enucleation and local resection (Omulecki et al 1994;Migdal & Macfarlane 1984), or bilateral enucleation (Oosterhuis et al 1982;Seregard et al 1988). A patient developed uveal melanoma 3.5 years after enucleation of the fellow eye for the same tumor and was managed by external beam radiotherapy (Eide 1989).…”

Section: Discussionmentioning

confidence: 99%

Sequential development of bilateral primary choroidal melanoma

Kıratlı

Bilgiç

2000

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

ABSTRACT.Purpose: A case of a woman who had bilateral choroidal melanoma diagnosed sequentially 20 months apart and managed conservatively is described. Methods: The first eye having a juxtapapillary melanoma was treated with a notched episcleral radioactive plaque. The second eye, initially containing a small nevus with unequivocal rapid growth, was managed with diode laser transpupillary thermotherapy. Results: Both tumors regressed considerably following treatment and the patient retained good visual acuity in both eyes. No other malignancies or metastasis were detected during the follow-up period. Conclusions: A small choroidal nevus rapidly grew after treating a choroidal melanoma in the fellow eye. Close follow-up of such patients is mandatory. Also, conservative treatment should be opted whenever possible given the unpredictable course of the opposite melanocytic lesion.

show abstract

“…We have previously described one patient with this syndrome who developed a melanoma in both eyes and three separate skin melanomas [8].…”

Section: Discussionmentioning

confidence: 99%

“…Only three patients -not having the dysplastic naevus syndrome -have been described [8,10,11]. The third combination of cutaneous and ocular melanoma, a primary cutaneous melanoma causing symptomatic metastasis to the eye, has a low incidence.…”

Section: Discussionmentioning

confidence: 99%