Primary Choriocarcinoma of the Stomach. A Case Report and Review of the Literature

Raghavapuram, Rahul; Veerankutty, Fadl H; Anandakumar, M

doi:10.1007/s13193-016-0494-4

Cited by 11 publications

(19 citation statements)

References 13 publications

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“…Choriocarcinoma is a malignant tumor that is characterized by the secretion of the beta subunit of human choriogonadotropin (β-HCG). It is a common tumor of the ovary and testis, being developed from trophoblastic or totipotent germ cells[1,2]. Choriocarcinoma can also occur in other organs such as the uterine body, brain (pineal gland), mediastinum, lung, retroperitoneum, urinary tract, liver, gallbladder, and gastrointestinal tract[1,3].…”

Section: Introductionmentioning

confidence: 99%

“…Primary choriocarcinoma of the stomach (PCCS) is an extremely rare (0.08% of all gastric cancers) but aggressive tumor (survival below six months) in which histogenesis and therapeutic management are still undefined[1,2]. PCCS was first described by Davidhon in 1905 and nominated as chorionepitheliom[4].…”

Section: Introductionmentioning

confidence: 99%

“…Until 2005, 142 cases of PCCS have been reported in total of which only 32 have been reported in English literature, with a male: female ratio of 2.3:1[1,2,5]. The reported cases were predominantly diagnosed in patients over 60 years old, with about 40% of cases occurring in the lower third of the stomach, with direct pancreatic or duodenal invasion[1,2]. Another 26 cases have been reported in English research literature between 2006 and 2018.…”

Section: Introductionmentioning

confidence: 99%

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Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report

Gurzu

Copotoiu

Tugui

et al. 2019

WJCC

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BACKGROUND Primary choriocarcinoma of the stomach (PCCS) is a rare tumor, with fewer than 60 cases published in the English-language literature up to December 2018. In this paper, we present the complex immunoprofile of one PCCS and a hypothesis regarding its histogenesis. CASE SUMMARY A 66-year-old previously healthy male underwent an emergency palliative gastrectomy for a gastric obstructive tumor. The histologic examination and immunoprofile of tumor cells showed a mixed tumor that consisted of choriocarcinoma (90%) and moderate differentiated adenocarcinoma (10%), with hepatic metastases (Stage pT2NxM1L1V1R0) and microsatelite stable status. The patient died one month after surgery. The tumor cells showed focal positivity for CDX2 (adenocarcinoma component), HCG (choriocarcinoma) and CD138 (plasmacytoid carcinoma component) and were negative for HER-2, α-fetoprotein, VEGF, maspin and markers of epithelial-mesenchymal transition. The gastric mucosa cells displayed positivity for CDX2, Hepar A and CD138. The complex immunoprofile and literature data synthesis prove that the gastric mucosa cells can present a multilineage differentiation. CONCLUSION PCCS should be considered as an aggressive variant of microsatellite stable gastric adenocarcinoma of an epithelial type, and not a germ cell tumor.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report

Gurzu

Copotoiu

Tugui

et al. 2019

WJCC

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“…Esta enfermedad es más frecuente en varones (relación de 2,3:1 respecto a las mujeres), y la edad media de presentación es de 60 años (5,7) . Los tumores suelen ser exofíticos, rojizos y se localizan en el tercio inferior del estómago (5,8) . Por otro lado, aunque no existen signos ni síntomas patognomónicos, la presentación más frecuente es la hemorragia gastrointestinal.…”

Section: Discussionunclassified

“…Por otro lado, aunque no existen signos ni síntomas patognomónicos, la presentación más frecuente es la hemorragia gastrointestinal. Además, al momento del diagnóstico, la mayoría presenta metástasis (5,8) . Sin embargo, en nuestro caso, esta no se evidenció.…”

Section: Discussionunclassified

Coriocarcinoma gástrico primario: reporte de caso

et al. 2019

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El coriocarcinoma gástrico primario (CGP) es un tumor infrecuente. Debido a su rareza, su patogenia aún no es clara. El diagnóstico se basa en la inmunohistopatología, la cual es positiva para gonadotropina coriónica humana (hCG). Es una neoplasia altamente invasiva y de rápida diseminación hematógena, lo que conlleva a un pobre pronóstico. Se presenta el caso de una paciente mujer de 57 años con hemorragia digestiva alta asociada a baja de peso. La gastroscopia reporta, a nivel de cardias y región paracardial, lesión polipoidea ulcerada de 5x4 cm, con bordes circunscritos y sin presencia de infiltración de pared adyacente, con estigmas de sangrado reciente y anatomía patológica que informa neoplasia maligna pleomórfica ulcerada con inmunohistoquímica positiva para panqueratina. Ante la sospecha de carcinoma poco diferenciado y sin evidencia de metástasis, la paciente fue sometida a gastrectomía total y la patología fue compatible con coriocarcinoma. Por ello, posterior a la cirugía, se realiza estudio de hCG sérico con resultado de 714 mIU/ml, lo que confirmó aún más el diagnóstico. Se decide tratamiento adyuvante con quimioterapia y se realiza seguimiento tomográfico y serológico de hCG sin presencia de enfermedad activa.

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A Positive Urine Pregnancy Test Leads to a Diagnosis of Primary Gastric Choriocarcinoma: Describing a Diagnostic Dilemma

Panda

Basu

Kalita

et al. 2022

Indian J Gynecol Oncolog

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Primary Choriocarcinoma of the Stomach. A Case Report and Review of the Literature

Cited by 11 publications

References 13 publications

Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report

Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report

Coriocarcinoma gástrico primario: reporte de caso

A Positive Urine Pregnancy Test Leads to a Diagnosis of Primary Gastric Choriocarcinoma: Describing a Diagnostic Dilemma

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