Primary chondrosarcomatous mesenchymoma of the mitral valve.

Muir, C. S.; Seah, C. S.

doi:10.1136/thx.21.3.254

Cited by 24 publications

(2 citation statements)

References 20 publications

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“…7 Regarding malignant tumors, Forker reports one case of primary sarcoma of the mitral valve which was considered a malignant transformation of a hamartoma,8 and Muir describes a patient with a chondrosarcomatous mesenchymoma originating in the vicinity of the mitral valve. 9 Histologic examination of the tumor in our patient revealed a primary benign tumor, but its precise classification was difficult. After taking into consideration diagnosis such as lipoma, hamartoma and mesenchymoma, a diagnosis of fibrolipoma was chosen in our case because of the histologic similarity to lesions of other sites so designated, in particular, soft pedunculated polyps of the skin otherwise known as molluscum pendulum.…”

Section: Pathologymentioning

confidence: 99%

Fibrolipoma of the mitral valve in a child. Clinical and echocardiographic features.

Barberger‐Gateau¹,

Paquet²,

Desaulniers³

et al. 1978

Circulation

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SUMMARY Echocardiographic examination, performed in a 12-year-old boy who had signs of mitral regurgitation, showed the presence of an abnormal mass of echoes in the left atrium and mitral orifice. These were initially interpreted as representing an atrial myxoma. Surgical exploration showed that the tumor originated from the posterior leaflet of the mitral valve, and, microscopically, the lesion was diagnosed as a fibrolipoma.The clinical and echocardiographic features of this unique type of cardiac tumor are discussed.PRIMARY TUMORS OF THE HEART are rare in infancy. The most frequent type is probably the rhabdomyoma which, in most cases, is associated with tuberous sclerosis.' 3 Few reports have appeared in the literature regarding primary tumors of heart valves in children.4 ' This report describes the clinical, echocardiographic and anatomical-pathological features of a fibrolipoma of the posterior leaflet of the mitral valve (PML) in an asymptomatic 12-year-old boy. Case ReportThe patient is a 12-year-old male who was referred to the pediatric cardiology department in October 1977 for evaluation of a heart murmur discovered at the time of an emergency room visit for a fracture of the right wrist. The child was asymptomatic with respect to the cardiovascular system and there was no history of rheumatic heart disease.On physical examination, the patient was welldeveloped and healthy looking. was 90/60. Peripheral pulses were normal and equal in all four limbs. On palpation of the precordium, the apex was displaced to the sixth left intercostal space at the anterior axillary line. On auscultation, the first heart sound was of normal intensity and the second heart sound was normally split. At the apex there was a grade 3/6 soft pansystolic murmur radiating to the axilla. Also at the apex, there was an S3 followed by a low frequency grade 2/6 diastolic rumble without presystolic accentuation. There was no opening snap. The lungs were clear to auscultation. The liver and the spleen were not enlarged. The ECG showed signs of left atrial enlargement. On the chest x-ray, the heart size was normal, with a slight prominence of the left ventricle and dilatation of the left atrium. There was prominence of the pulmonary veins in the upper third of the lungs, suggesting the presence of pulmonary venous congestion. Complete blood count, erythrocyte sedimentation rate and protein electrophoresis were all normal.Echocardiography ( fig. 1

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Section: Pathologymentioning

confidence: 99%

Fibrolipoma of the mitral valve in a child. Clinical and echocardiographic features.

Barberger‐Gateau¹,

Paquet²,

Desaulniers³

et al. 1978

Circulation

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“…Primary cardiac tumours are rare and only 25 % are reported to be malignant (9). Malignant mesenchymomas are extremely rare and only 3 cases have been published (3,6,8) until now.…”

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confidence: 99%

Malignant Mesenchymoma of the Heart Presenting as Mitral Stenosis

Frandsen

Andersen

Nielsen

1981

Journal of Internal Medicine

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ABSTRACT. Malignant mesenchymoma of the left atrium obstructing the mitral orifice was revealed at autopsy in a 39‐year‐old woman with a history indicating mitral stenosis. Minor tumour nodules were found in the walls of the right and left ventricle together with a few distant metastases. Clinical findings in primary cardiac tumours and the rarity of primary malignant mesenchymoma of the heart are discussed.

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Bony and cartilaginous tumors of the heart and great vessels.Report of an osteosarcoma of the pulmonary artery

McConnell

1970

Cancer

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An osteosarcoma of the pulmonary artery is reported, and 8 other cases of tumors of the heart and great vessels containing bony or cartilaginous components are reviewed. All arose near the base of the heart, and all contained a fibrosarcomatous element. Women in the fourth and fifth decade are most frequently affected and survive an average of 27 months from first symptom. These tumors are sluggishly aggressive, but eventually fatal because of their critical location. They probably arise from fibrous tissue of the cardiac valves, atrioventricular groove, or vascular intima and undergo malignant metaplasia into bone, cartilage, and other mesenchymal elements.

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Primary chondrosarcomatous mesenchymoma of the mitral valve.

Cited by 24 publications

References 20 publications

Fibrolipoma of the mitral valve in a child. Clinical and echocardiographic features.

Fibrolipoma of the mitral valve in a child. Clinical and echocardiographic features.

Malignant Mesenchymoma of the Heart Presenting as Mitral Stenosis

Bony and cartilaginous tumors of the heart and great vessels.Report of an osteosarcoma of the pulmonary artery

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