Primary Chondrosarcoma in the Liver of a Dog

Chikata, S.; Nakamura, Sayaka; Katayama, Rie; Yanagisawa, S.; Matsuo, Yusuke; I, Yamane; Takahashi, Koji

doi:10.1354/vp.43-6-1033

Cited by 27 publications

(21 citation statements)

References 12 publications

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“…Our histological, immunohistochemical and ultrastructural findings are similar to those reported previously for extraskeletal myxoid chondrosarcoma in man and other animals [8,17,18]. In dogs, extraskeletal chondrosarcoma occurs in the lung [19], omentum [19], heart including pericardium [1,9,13,19,22], spleen [15], abdomen [20], retroperitoneum [16], and liver [3]. Most previously reported cases involved variants of extraskeletal mesenchymal chondrosarcoma and occurred in adult or old dogs aged 18 months to 17 years (mean 7.8 years).…”

supporting

confidence: 88%

Extraskeletal Myxoid Chondrosarcoma with Systemic Metastasis in a Five-Month-Old Irish Setter Dog

Kojima

Hatai

Oyamada

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Extraskeletal myxoid chondrosarcoma was found in a five-month-old male Irish setter dog. At necropsy, the largest mass, measuring 15 × 13 × 13 cm, was found in the right caudal lobe of the lung, and metastatic small masses were observed in multiple organs. Microscopically, the tumor comprised mainly atypical mesenchymal cells and myxoid stroma, which stained positively with Alcian blue. Immunohistochemically, the tumor cells stained positively for vimentin, S-100 protein, neuron-specific enolase, calretinin, and chromogranin A. Ultrastructurally, the cytoplasm of the tumor cells was comprised abundant rough endoplasmic reticulum, mitochondria, Golgi complex, free ribosomes and short irregular microvillous processes extending from the cytoplasm. Based on these pathological findings, this tumor was diagnosed as extraskeletal myxoid chondrosarcoma. Primary chondrosarcomas arise from existing normal cartilage and perichondrium at sites such as the pelvis, nasal cavity, sternum, and ribs, and less often in long bones. Extraskeletal chondrosarcoma was first described as an entity in 1953 by Stout and Verner [23]. Characteristically, in most reported cases, extraskeletal chondrosarcoma exhibits less aggressive behaviour than its skeletal counterpart [5,21,24].A series of extraskeletal myxoid chondrosarcoma in man was described in 1972 by Enzinger and Shiraki [5]. Almost all the tumors in this series affected adults (mean age 49 years), and the only child was a 13-year-old girl. In animals, reports of extraskeletal chondrosarcoma are rare, and most cases have been described as a single mass in adult or old dogs [1,9,13,19,22]. In this case report, we describe an extraskeletal myxoid chondrosarcoma with systemic metastasis in a five-month-old dog.A five-month-old male Irish setter dog was referred to our veterinary hospital with a history of anorexia, dyspnea, diarrhea, and exophthalmos of the left eye. The dog had been fully vaccinated, and there was no previous medical or surgical history. Under sedation, radiographs of the thoracic cavity were taken and confirmed the presence of a large, poorly defined mass lying within the right caudal lobe of lung. Approximately three-fourths of the thoracic cavity was occupied by the pulmonary mass, and systemic metastasis was confirmed by abdominal radiographs. Because of the poor prognosis, the dog was euthanized. A necropsy examination was performed.Tissue samples from all major organs and masses were fixed in 10% buffered formalin, embedded in paraffin wax, and sectioned. All sections were stained with hematoxylin and eosin (HE), and selected sections were prepared for staining for Alcian blue (pH 2.5), periodic acid-Schiff (PAS), and immunohistochemistry. The following primary antibodies were used: S-100 protein (Nichirei Biosciences, Tokyo, Japan), neuron-specific enolase (NSE, Nichirei), vimentin (Nichirei), cytokeratin (CK) AE1/AE3 (Nichirei), α-smooth muscle actin (SMA, Dako-Japan, Kyoto, Japan), desmin (Dako-Japan), calretinin (Zymed Laboratories, Carlsbad, CA, ...

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confidence: 88%

Extraskeletal Myxoid Chondrosarcoma with Systemic Metastasis in a Five-Month-Old Irish Setter Dog

Kojima

Hatai

Oyamada

et al. 2012

The Journal of Veterinary Medical Science

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“…Primary chondrosarcoma has been reported in appendicular skeleton, synovium, trachea, larynx, lung, liver, subcutaneous, digit, tongue, kidney, abdominal wall, pulmonary artery, omentum, mammary gland, heart and urethra [2][3][4][6][7][8][9][10][11] . In veterinary literature, canine skeletal chondrosarcoma accounts for 1-13% of all chondrosarcomas [1,5] .…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical and Histopathological Findings of Chondrosarcoma in Mammary Gland of A Dog: A Case Report

Golshahi¹,

Tavasoly²,

Rezaie³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryChondrosarcoma is a malignant tumor of chondrocytes and occurs most commonly on the flat bones and the nasal cavity. Mammary chondrosarcoma is an uncommon tumor in canine practice. The aim of present paper is to report a case of mammary chondrosarcom in a 10-year-old German shepherd bitch. The dog with a mass in her right caudal thoracic mammary gland which grown gradually in 8 months, was referred to the veterinary teaching hospital. The mass and local lymph nodes were resected by complete mastectomy and were sent to department of veterinary pathology for histopathological examination. Macroscopically, the mass was fluctuant containing firm mases in it, totally measuring 5×4×5 cm in diameter. The cross section was yellow and there were many cavernous structures which were filled with grayish fluid. Microscopic examination revealed a mass of large mature cartilage structures with lacunae and chondrocytes and chondroblastes with new forming structures of cartilage. Immonohistochemical investigation revealed that the tumor is negative for Estrogen receptor (ER) expression. According to macroscopic and microscopic investigations chondrosarcoma was diagnosed.

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“…These tumors are relatively well described in the veterinary literature, having been diagnosed in most domestic species to include a variety of dog breeds 2 , 4 , 5 , 6 , 7 , 8 , cats 1 , ferrets 9 , sheep 10 , horses 11 , cows 9 , 12 , 13 as well as single reports in the mandible of a camel 14 and the humerus of a goat 15 . In dogs, cats and horses there are occasional reports of extraskeletal chondrosarcomas described as primary to various tissues, including the retroperitoneal space 6 , the pericardium 16 , the liver 4 , spleen 5 , mammary gland 17 , tongue 18 and subcutaneous tissues 13 , 19 . In the majority of reports in domestic species, chondrosarcomas arise with greater frequency in the flat bones as opposed to the long bones.…”

mentioning

confidence: 99%

“…The sternocostal complex appears to be the primary predilection site in sheep while dogs have a statistically significant predominance of tumors arising in the ribs and nasal cavity 3 . Tumor explantation from a chondrosarcoma into a body cavity has been reported in the medical literature 4 , 20 , 21 , mimicking the macroscopic presentation of malignant mesothelioma or carcinomatosis secondary to seeding from a distant epithelial tumor, but while widespread chondrosarcoma metastasis to solid organs has been described in the veterinary literature, explantation within the thoracic cavity has only been suggested once in a single animal in combination with widespread metastasis and organ invasion 12 .…”

mentioning

confidence: 99%

Costal Mesenchymal Chondrosarcoma with Diffuse Pleural and Pericardial Explantation in a Pygmy Goat

Lombardini

Concha

Pierce³

et al. 2014

J Toxicol Pathol

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A 3 year old intact male pygmy goat developed progressive weakness and eventual recumbancy over the course of 1 week, while maintaining its ability to eat and drink. The animal died and at necropsy, the parietal pleural surfaces and the pericardial surface were noted to be covered with firm, white, variably sized nodules that often formed linear arrays or coalesced into larger clumped aggregates. The visceral pleural surfaces of the ventral lung lobes were also covered with similar nodules. Histopathological and immunohistochemical evaluation of the submitted tissues revealed a diagnosis of mesenchymal chondrosarcoma with extensive seeding throughout the thoracic cavity.

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Primary Chondrosarcoma in the Liver of a Dog

Cited by 27 publications

References 12 publications

Extraskeletal Myxoid Chondrosarcoma with Systemic Metastasis in a Five-Month-Old Irish Setter Dog

Extraskeletal Myxoid Chondrosarcoma with Systemic Metastasis in a Five-Month-Old Irish Setter Dog

Immunohistochemical and Histopathological Findings of Chondrosarcoma in Mammary Gland of A Dog: A Case Report

Costal Mesenchymal Chondrosarcoma with Diffuse Pleural and Pericardial Explantation in a Pygmy Goat

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