Primary cervical melanoma with brain metastases

Salpietro, Francesco M.; Alafaci, Concetta; Gervasio, Olga; Rosa, G. La; Baio, Ambrogia; Francolini, Dario Cavallini; Batolo, D; Tomasello, Francesco

doi:10.3171/jns.1998.89.4.0659

Cited by 45 publications

(25 citation statements)

References 51 publications

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“…Salpietro et al ( 33 ) reported that specific immunotherapy was an important adjuvant method in the treatment of small residual malignant melanoma lesions, and presented low toxicity. High doses of IFNβ or IFNα-2b may improve disease control and prolong survival time, but the dosage required is disputed and difficult to tolerate.…”

Section: Discussionmentioning

confidence: 99%

Intracranial malignant melanoma: A report of 7 cases

Gui

Lang

2015

Oncology Letters

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The aim of the present study was to investigate the clinical diagnosis and treatment of intracranial malignant melanoma. For this purpose, the clinical manifestation, signs, cerebrospinal fluid (CSF) contents, imageology, pathological features, treatment and prognosis of 7 cases of intracranial malignant melanoma were analyzed in The Chinese PLA General Hospital (Beijing, China) from 1996 to 2013. All the melanoma cases were confirmed by histopathology, and CSF cytopathology demonstrated that there were 5 cases of primary malignant melanoma and 2 cases of secondary malignant melanoma. Among the patients, 4 presented with >1 pigmented nevus in the skin, and 1 presented with skin melanoma. Intracranial malignant melanoma mostly affects middle-aged males. CSF cytopathology and imageology (particularly enhanced magnetic resonance), are important tools in the diagnosis of the disease. Particularly, when a patient presents with a pigmented nevus in the skin and an abnormal lesion in the brain, a diagnosis of intracranial malignant melanoma should be considered.

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Section: Discussionmentioning

confidence: 99%

Intracranial malignant melanoma: A report of 7 cases

Gui

Lang

2015

Oncology Letters

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“…In humans, melanocytes can be found in skin, mucous membranes, parenchyma, and uvea. [ 3 4 5 ] In most instances, melanomas involving the CNS represent metastatic disease. Melanoma is the most common tumor, after lung and breast cancers, which produces brain metastases.…”

Section: Discussionmentioning

confidence: 99%

“…[ 11 ] The differential diagnoses of leptomeningeal tumors include meningioma, meningeal melanocytoma, leptomeningeal melanosis, metastases, and sarcoma. [ 4 5 ] It is difficult to distinguish primary CNS melanoma from metastatic melanoma on neuroimages alone. [ 12 ] Hayward[ 13 ] proposed the following factors for establishing a diagnosis of a primary CNS melanoma: (a) No malignant melanoma outside the CNS, (b) leptomeningeal involvement, (c) intramedullary spinal lesions, (d) hydrocephalus, (e) tumor location in the pituitary or pineal gland, and (f) a single intracerebral lesion.…”

Section: Discussionmentioning

confidence: 99%

A unique case of primary intracranial melanoma

et al. 2018

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“…8) The average survival of patients with primary spinal malignant melanoma is 5–6 years after the onset of symptoms, which is clearly longer compared to central nervous system metastasis of cutaneous malignant melanoma, which exhibits a fast progression with systemic spread and leads to a fatal outcome in <6 months. 5,8),13) A previous report stated that the presence of the blood brain barrier in the spinal cord prevents hematogenous spread and hampers the process of metastasis. 4) Considering the slow progression primary spinal malignant melanoma, it is critical to establish a precise diagnosis, because patients should undergo tumor removal to slow down the onset of neurological deficits, even in the case of central nervous system dissemination.…”

Section: Discussionmentioning

confidence: 99%

“…4,8) The mean survival time of patients with primary spinal malignant melanoma is approximately 6 years after symptom onset. 5,8) These facts indicate that surgical excision and postoperative adjuvant therapy, such as radiotherapy and chemotherapy, should be used for slowing the onset of neurological deficits, even in cases with central nervous system dissemination. 3,9) To our knowledge, this is the first report of an incidental discovery of primary spinal malignant melanoma in a patient who was treated with only surgery and who survived >5 years without recurrence or dissemination.…”

Section: Introductionmentioning

confidence: 99%

Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

Kawanabe¹,

Ueda²,

Sasaki³

et al. 2014

NMC Case Report Journal

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The present case illustrates the incidental detection of a primary malignant melanoma of the thoracic spinal cord before central nervous system dissemination. A 54-year-old female fell down and bruised the thoracolumbar region. The patient visited a local doctor and underwent magnetic resonance imaging (MRI) of the thoracic and lumbar spine to rule out vertebral fractures. MRI revealed no vertebral fracture, but an intradural extramedullary mass was observed at the T12 level. She was referred to our hospital in October 2008. MRI showed that the mass appeared hyperintense on T1-weighted images and hypointense on T2-weighted images. T1-weighted MRI with gadolinium showed a mild homogeneous enhancement of the lesion. The patient underwent laminectomy at T11–L1, along with the complete removal of the tumor, and she exhibited no remarkable symptoms after surgery. Histopathological examination confirmed the diagnosis of malignant melanoma. Malignant melanoma was not detected elsewhere in the body. Neither radiotherapy nor chemotherapy was performed after surgery. Her neurological examination was unremarkable 5 years after the surgery and no tumor recurrence was detected. The present case suggests that patients with primary spinal malignant melanoma may survive >5 years without recurrence after complete surgical removal of the tumor alone. Complete removal of the tumor before central nervous system dissemination may be critical for treatment in such cases. Precise diagnosis via MRI may increase the detection of primary spinal malignant melanoma before central nervous system dissemination, thus facilitating prompt surgical removal, improving the prognosis of patients.

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Primary cervical melanoma with brain metastases

Cited by 45 publications

References 51 publications

Intracranial malignant melanoma: A report of 7 cases

Intracranial malignant melanoma: A report of 7 cases

A unique case of primary intracranial melanoma

Incidental Detection of Primary Spinal Malignant Melanoma before Central Nervous System Dissemination

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