Primary cerebral leiomyosarcoma

Primary Intracranial Leiomyosarcoma: Report of a Case and Review of the Literature

“…Primary intracranial sarcomas are extremely rare [2]. Intracranial sarcomas appear to originate from leptomeningeal lining and usually have dural attachment [3]. Pleuripotent mesenchymal stem cells in the dura are probably the cells of origin.…”

Primary intracranial β-human chorionic gonadotropin–producing leiomyosarcoma in a 2-year-old immunocompetent child

“…A few other cases of young children (age range 4-9 years) with primary intracranial LMS are documented in the literature, 15,21,24 although their immune status was not always detailed. Due in part to the rarity of primary intracranial LMS, there is no standard treatment regimen.…”

“…23 In the sporadic reports of primary intracranial sarcomas, treatment plans and clinical outcomes have been variable. 21 The use of radiation therapy after maximal resection of primary intracranial LMS has been documented by several authors 9,12,14,15,21,27 and may be considered useful. 11 The role of chemotherapy is unclear, and a particular regimen has not been established.…”

Metastatic Leiomyosarcoma of the Brain Manifesting as Multiple Hemorrhages-Case Report-

“…Intracranial leiomyosarcoma is a very uncommon tumor in the central nervous system. 3) Metastases from uterine or retroperitoneal leiomyosarcoma occur more commonly than primary lesions, but primary leiomyosarcoma has recently been reported in the context of immunosuppression due to human immunodeficiency virus 4,6,19,21,23,30) or radiation therapy. 26) A recent study of 3829 patients with soft tissue sarcoma found the prevalence of brain metastases was approximately 1%, with leiomyosarcoma accounting for 20% of these metastatic lesions.…”