Primary Central Nervous System Lymphoma in Patients with and without the Acquired Immune Deficiency Syndrome

Remick, Scot C.; Diamond, Catherine; Migliozzi, Joseph A.; Solis, Otelo G.; Wagner, Henry; Haase, Richard F.; Ruckdeschel, John C.

doi:10.1097/00005792-199011000-00003

Cited by 105 publications

(32 citation statements)

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“…Similar to most reported studies, the median age of our patients was 59 years, and a slight male predominance was observed [10,11]. It is of importance that in all 37 patients in our series, the lymphomas comprised of large B cells, consistent with previous studies in which more than 98% of PCNSL were reported to be B-cell lymphomas [12].…”

Section: Discussionsupporting

confidence: 91%

Primary Central Nervous System Lymphoma in an Asian Population: A 15-Year Experience

Quek¹,

Ty²,

Lim³

et al. 2006

Oncol Res Treat

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The aim of this study was to characterize primary central nervous system lymphoma (PCNSL) among Asian patients and to determine their outcomes with different therapeutic modalities. Patients and Methods: Between 1990 and 2005, 37 patients with PCNSL were analyzed within 5 different treatment groups: radiotherapy alone (arm A), combined chemoradiation (arm B), chemotherapy alone with methotrexate (MTX) ≥ 1 g/m² (arm C), miscellaneous therapy (arm D), and best supportive care (arm E). Results: The median age at presentation was 59 years, and the majority of patients were male (68%). All patients had aggressive diffuse large B-cell lymphoma. The number of patients in arms A to E were 6, 16, 3, 8 and 4, respectively. The overall median survival was 7.4 months, 54.1 months, not reached, 8.9 months and 0.9 months, respectively. Use of MTX 1-2.5 g/m² per cycle and an ECOG performance status of 0-2 were each associated with improved survival on univariate analysis (p = 0.022 and p = 0.049, respectively). Compared to radiotherapy alone, use of combined chemo-radiation was associated with a trend towards improved overall median survival (7.4 vs. 54.1 months, p = 0.058). Conclusion: The clinical characteristics and treatment outcomes in our Asian patients were comparable to those reported in Western series. Use of MTX 1-2.5 g/m² per cycle and an ECOG performance status of 0-2 were associated with improved survival.

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Section: Discussionsupporting

confidence: 91%

Primary Central Nervous System Lymphoma in an Asian Population: A 15-Year Experience

Quek¹,

Ty²,

Lim³

et al. 2006

Oncol Res Treat

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“…Common debut symptoms, such as personality changes and headache, 23 are unspecific, and findings on diagnostic imaging may be variable or inconclusive. [25][26][27] In a previous study, we observed that there was a considerable delay in the diagnosis of PCNSL. 28 However, considering the advances in diagnostic imaging technologies the last decades and the reported improvements in treatment for PCNSL, we hypothesized that there has been a reduction in diagnostic delay and that overall survival has improved for patients with PCNSL over time in Norway.…”

mentioning

confidence: 99%

Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989–2003

Haldorsen

Krossnes

Aarseth

et al. 2007

Cancer

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The purpose of this study was to examine the influence of some swelling agents with reduced water content on final properties of cotton fabrics. A single‐step swelling of cotton in the reagent was used. There were selected properties generally used to characterize mercerized cotton that are technologically important, such as water retention, shrinkage, stiffness, crease recovery angle, and hand. Water retention method and dyeing with CI Direct Red 81 have been used to compare the degree of swelling for different samples. Correlations have been established between structural changes induced by the swelling agents and final properties of cotton fabric. The mixtures of an alkali solution and an additive produced similar or better end‐use properties as compared with classical sodium hydroxide or ammonia treatments, combining the action of a diluted alkali solution (3.13 mol/L NaOH or KOH) and a nonalkali reagent. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 2848–2855, 2006

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“…Com-mon debut symptoms such as personality change or symptoms of raised intracranial pressure [3,12] are non-specific and findings at computerized tomography (CT) and magnetic resonance imaging (MRI) are variable and may not suggest the diagnosis [18]. The time from initial symptoms to final diagnosis of PCNSL had a median of 1.5 Á/5 months in foreign studies of non-AIDS patients [19Á/21] and a mean of 3 months for non-AIDS and 2 months for AIDS patients in a review of studies published 1980 Á/1992 [3].…”

mentioning

confidence: 99%

Diagnostic delay in primary central nervous system lymphoma

et al. 2005

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Primary Central Nervous System Lymphoma in Patients with and without the Acquired Immune Deficiency Syndrome

Cited by 105 publications

References 0 publications

Primary Central Nervous System Lymphoma in an Asian Population: A 15-Year Experience

Primary Central Nervous System Lymphoma in an Asian Population: A 15-Year Experience

Increasing incidence and continued dismal outcome of primary central nervous system lymphoma in Norway 1989–2003

Diagnostic delay in primary central nervous system lymphoma

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