Primary central nervous system lymphoma in children and adolescents: low relapse rate after treatment according to Non-Hodgkin-Lymphoma Berlin-Frankfurt-Munster protocols for systemic lymphoma

Thorer, Heike; Zimmermann, Martin; Makarova, Olga; Oschlies, Ilske; Klapper, Wolfram; Lang, Peter; Stackelberg, Arend von; Fleischhack, Gudrun; Worch, Jennifer; Juergens, Heribert; Woessmann, Wilhelm; Reiter, Alfred; Burkhardt, Birgit

doi:10.3324/haematol.2014.109553

Cited by 30 publications

(31 citation statements)

References 13 publications

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“…3,5,7,8 The most common presenting symptoms are manifestations of increased intracranial pressure, including headache, vomiting, visual changes, or altered mental status. 4 The optimal modality for neuroimaging in suspected cases is a contrast-enhanced brain magnetic resonance imaging scan.…”

Section: Clinical and Histologic Featuresmentioning

confidence: 99%

“…In adults, the histology in more than 90% of cases is DLBCL, which is also the most common subtype in pediatrics, but the incidence of this subtype in children ranges from 30% to 70%. [3][4][5]7,8 Other common histologic subtypes in pediatrics are anaplastic large cell lymphoma (ALCL), Burkitt lymphoma, and lymphoblastic lymphoma.…”

Section: Clinical and Histologic Featuresmentioning

confidence: 99%

“…In pediatrics, less is known regarding prognosis; however, outcomes in recent series are similar to that of systemic NHL with CNS disease with 3-year overall survival (OS) of 62% to 83%. 3,5,7,8,10 Role of surgical resection PCNSL is a diffuse and often multifocal disease. In both children and adults, the role of surgery is generally restricted to biopsy for diagnostic purposes or, in rare cases, emergent debulking to relieve impending brain herniation.…”

Section: Clinical and Histologic Featuresmentioning

confidence: 99%

“…The 3-year OS among immunocompetent patients was 92%, suggesting the majority of pediatric patients can be successfully treated without WBRT. 7 Given the potential for serious neurotoxicity that can result from WBRT in children, 21 this treatment modality should be reserved for refractory or relapsed patients.…”

Section: 9mentioning

confidence: 99%

“…There have been case reports and case series describing approximately 100 cases over the course of last 20 years. [3][4][5][6][7][8] In this minireview, we summarize data from recent pediatric series (Table 1), as well as clinical trials in adults, to guide the treatment of PCNSL in children.…”

Section: Introductionmentioning

confidence: 99%

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Management of primary central nervous system lymphoma in children

2016

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A 14-year-old boy with no significant past medical history presents with headaches and vomiting and is found to have a 2 × 3-cm left parietal lobe mass. A stereotactic biopsy reveals diffuse large B-cell lymphoma (DLBCL). Cerebrospinal fluid cytology, as well as bone marrow biopsies are negative, and a whole-body positron emission tomography/computed tomography scan does not demonstrate other areas of disease. The primary medical team asks how you would treat this patient.

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Section: Clinical and Histologic Featuresmentioning

confidence: 99%

Section: Clinical and Histologic Featuresmentioning

confidence: 99%

Section: Clinical and Histologic Featuresmentioning

confidence: 99%

Section: 9mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Management of primary central nervous system lymphoma in children

2016

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High‐dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for pediatric primary central nervous system lymphoma in first complete remission

Rajagopal

Miles

Kotecha

2017

Cancer

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Primary central nervous system lymphoblastic B cell lymphoma located at cerebellum in a child: A case report and literature review

Yang

Duan

Zhou

et al. 2021

Pediatric Investigation

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Introduction Primary central nervous system lymphoma (PCNSL) is extremely rare in pediatric population. We reported a case of PCNSL in a 3‐year‐old girl and reviewed the literature in the past three decades. Case presentation A 3‐year‐old girl presented with gait disturbance. A contrast‐enhanced magnetic resonance image of the brain showed a solitary bulky mass in the left cerebellar hemisphere, hydrocephalus and cerebellar tonsillar hernia. Surgical resection was performed and the patient was diagnosed with primary central nervous system lymphoblastic B cell lymphoma. Then the patient received regular chemotherapy, including 6 cycles of chemotherapy containing high‐dose methotrexate (HD‐MTX). The patient remains alive 15 months after the diagnosis with no evidence of active disease, but suffered twice chronic subdural hematoma, which was treated by burr hole drainage. Conclusion Lymphoblastic B cell lymphoma is a rare histologic subtype of pediatric PCNSL. Chemotherapy containing HD‐MTX remains the most effective treatment. The patient should avoid head impact after surgical resection of the tumor to prevent chronic subdural hematoma.

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Primary central nervous system lymphoma in children and adolescents: low relapse rate after treatment according to Non-Hodgkin-Lymphoma Berlin-Frankfurt-Munster protocols for systemic lymphoma

Cited by 30 publications

References 13 publications

Management of primary central nervous system lymphoma in children

Management of primary central nervous system lymphoma in children

High‐dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for pediatric primary central nervous system lymphoma in first complete remission

Primary central nervous system lymphoblastic B cell lymphoma located at cerebellum in a child: A case report and literature review

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