Primary central nervous system lymphoma

Quah, Boon Leong; Munusamy, Thangaraj; Watts, Colin

doi:10.1093/med/9780198746706.003.0009

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A role in the pathophysiology of lymphomas of the CNS is conceivable. Approximately 20-30% of patients with primary CNS lymphoma (PCNSL) have ophthalmic involvement at the time of diagnosis, often affecting both eyes (74). Likewise, 90% of patients with primary intraocular lymphoma (PIOL) go on to develop PCNSL (75).…”

Section: Further Relevance Of An Ocular-cerebral Glymphatic Circulationmentioning

confidence: 99%

“…PCNSL has a predilection for periventricular regions, is closely related to the subarachnoid space, and is often seen tracking along Virchow-Robin spaces (74,75,78,79). In PIOL or PCNSL with ocular involvement, perivascular sheathing and vascular staining are found often and this is explained by tumor cell presence in retinal vascular walls (77).…”

Section: Further Relevance Of An Ocular-cerebral Glymphatic Circulationmentioning

confidence: 99%

See 1 more Smart Citation

An explanation for Terson syndrome at last: the glymphatic reflux theory

et al. 2021

View full text Add to dashboard Cite

Terson Syndrome (TS) describes the presence of intraocular hemorrhage in patients with intracranial hemorrhage, typically subarachnoid hemorrhage. Despite TS being a well-defined and frequently occurring phenomenon, its pathophysiology remains controversial. This review will present the current understanding of TS, with view to describing a contemporary and more plausible pathomechanism of TS, given recent advances in ophthalmic science and neurobiology. Previously proposed theories include a sudden rise in intracranial pressure (ICP) transmitted to the optic nerve sheath leading to rupture of retinal vessels; or intracranial blood extending to the orbit via the optic nerve sheath. The origin of blood in TS is uncertain, but retinal vessels appear to be an unlikely source. In addition, an anatomical pathway for blood to enter the eye from the intracranial space remains poorly defined. An ocular glymphatic system has recently been described, drainage of which from the globe into intracranial glymphatics is reliant on the pressure gradient between intraocular pressure and intracranial pressure. The glymphatic pathway is the only extravascular anatomical conduit between the subarachnoid space and the retina. We propose that subarachnoid blood in skull base cisterns near the optic nerve is the substrate of blood in TS. Raised ICP causes it to be refluxed through glymphatic channels into the globe, resulting in intraocular hemorrhage. We herewith present glymphatic reflux as an alternative theory to explain the phenomenon of Terson Syndrome. Response to Reviewers:Many thanks, please see the attached Word document which contains all responses to reviewer and editor comments in red. These are copied below as well.

show abstract

Section: Further Relevance Of An Ocular-cerebral Glymphatic Circulationmentioning

confidence: 99%