Primary central nervous system germ cell tumors. Effect of histologic confirmation on radiotherapy

Kersh, C.R.; Constable, William C.; Eisert, Donald R.; Spaulding, Cynthia A.; Hahn, Seung S.; Jenrette, Joseph M.; Marks, Richard D.

doi:10.1002/1097-0142(19880601)61:11<2148::aid-cncr2820611103>3.0.co;2-q

Cited by 56 publications

(12 citation statements)

References 20 publications

(2 reference statements)

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“…The impact of radiation volume in intracranial germinomas has been discussed above; summary data are given in Table 13.7 suggesting superior results with full neuraxis irradiation. Similar differences have been documented in published reviews, yet remain unconfirmed in most single-institution reports (LINSTADT et al 1988;LEGIDO et al 1989;DEARNALEY et al 1990;KERSH et al 1988). Failures occur predominantly within the first 5 years; up to 10%-15% late recurrence has been noted between 5 and 10 years after therapy (SUNG et al 1978;GLANZMAN and SEELENTAG 1989).…”

Section: Results Of Treatmentsupporting

confidence: 60%

Radiation Therapy in Pediatric Oncology

Cassady¹

1994

Medical Radiology

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The use of general descriptive names, registered, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Thomson Press (India) Ltd., New Delhi SPIN: 1 0042321 21 13130/SPS -5 4 3 2 I 0 -printed on acid-free paper PrefaceThis book provides a thorough review of the role that radiation therapy currently plays in the management of most childhood tumors. Extensively augmented with figures and tables where appropriate, it also provides a concise review of current diagnostic and therapeutic approaches for major childhood malignancies. Extensive and up-to-date reference lists are an added benefit. Chapters on principles of pediatric radiation therapy, etiology of childhood tumors, and newer, molecular approaches in pediatric oncology are provided.Authors include leaders in the field writing on their particular areas of interest and expertise, providing a diversity of approach useful to the reader.Many people have been responsible for this book. Primary thanks must go to our many childhood patients and their parents who have allowed us the privilege of treating them. Appreciation and thanks are due to my many teachers and particular role models, HENRY

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Section: Results Of Treatmentsupporting

confidence: 60%

Radiation Therapy in Pediatric Oncology

Cassady¹

1994

Medical Radiology

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“…GCTs are the most common subtype of pineal gland tumor. In the literature, the incidence of GCTs varies from 50% to 75% of tumors in the pineal region [3–5]. These tumors arise from pluripotential germ cells, which normally do not inhabit the pineal gland.…”

Section: Introductionmentioning

confidence: 99%

Pineal gland tumors: experience from the SEER database

et al. 2009

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Pineal gland tumors are rare and account for less than 1% of all primary brain tumor diagnoses. Also, they are more commonly seen in pediatric patients than in adults. We analyzed the available SEER data on pineal gland tumors that were diagnosed during the period 1973–2005. The cohort was subdivided into groups on the basis of tumor histology: germ cell tumors, pineal parenchymal tumors, gliomas, and other pineal tumors. Analyses of incidence, survival, factors influencing survival, and treatment modality are provided. Among the 633 patients with pineal tumors, male sex was predominant, i.e., sex ratio was 3:1 for the whole group and 11.8:1 for those with germ cell tumors. The 5-year overall survival (OS) for the cohort was 65% ± 2.1%. Those with germ cell tumors experienced the best survival (OS = 78.9% ± 2.3%), followed by those with gliomas (OS = 61% ± 9.3%), and those with pineal parenchymal tumors (OS = 47.2% ± 4.2%). Non–germ cell tumors, no radiotherapy, and diagnosis before 1993 were the only factors associated with a negative impact on survival. The extent of surgical tumor resection did not affect survival in any histologic subgroup. We conclude that although pineal tumors are histologically diverse, they share some similarities due to their unique location. An aggressive surgical approach should be considered with caution in this region. Further studies on different pineal tumors subtypes are needed.

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“…For other CNSGCTs, such as mixed germinomas and teratomas, radiotherapy has also played a major role in curative treatment but with lower control rates, varying between 40% and 70% (9)(10)(11). Under these circumstances, radiotherapeutic management requires craniospinal irradiation (CSI) as the initial treatment volume and intracranial dose levels of 50 Gy and above as the appropriate doses for obtaining successful tumoricidal effect and local tumor control (7,12,13).…”

Section: Introductionmentioning

confidence: 99%