Primary cardiac tumors in children

Arciniegas, Eduardo; Hakimi, Mehdi; Farooki, Zia Q.; Truccone, Nestor J.; Green, Edward W.

doi:10.1016/s0022-5223(19)37924-3

Cited by 109 publications

(18 citation statements)

References 33 publications

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“…In children, rhabdomyomas remain the most common benign neoplasm and occur in 50Oh of cases. 40,[43][44][45] Although seen infrequently, other benign primary cardiac neoplasms in adults incl ud e I i m porn as, pa pi I I a ry f i broe I a st om as, hem an g i o m as, at r i ove n t r i c u I a r node m F? sothelimomas, and fibromas (Table l).…”

Section: Primary Cardiac Tumors: Benign Myxomasmentioning

confidence: 99%

Cardiac Neoplasms: Current Diagnosis, Pathology, and Therapy

1988

J Cardiac Surgery

119

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Cardiac neoplasms remain enigmatic because of their rarity and protean clinical manifestations. Although surgery for benign cardiac neoplasms seems straightforward, certain difficulties in diagnosis and extirpation often exist. Newer diagnostic modalities including intraoperative transesophageal echocardiography seem promising and may provide better planning for the surgeon. Moreover, cardiac transplantation has provided relief for some patients with irresectable benign neoplasms. As ventricular arrhythmias may emanate from benign tumors, electrophysiologically guided extirpation may provide helpful control. Malignant cardiac tumors remain the true challenge, whether primary or metastatic, as little surgical or medical progress has resulted. This review examines nearly all diagnostic, pathological, histologic, and therapeutic aspects of benign and malignant cardiac tumors. Moreover, the various surgical approaches necessary for removal of resectable neoplasms are detailed.

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Section: Primary Cardiac Tumors: Benign Myxomasmentioning

confidence: 99%

Cardiac Neoplasms: Current Diagnosis, Pathology, and Therapy

1988

J Cardiac Surgery

119

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“…In a compilation of 2 autopsy series, the frequency of primary cardiac tumors was 0.02% or 200 per million2 and the reported incidence among the general population has varied between 0.001% and 0.03% in most series. Nearly a quarter of the primary cardiac tumors diagnosed in adults are malignant,3 mostly sarcomas, compared with children, in whom <10% of the primary cardiac tumors are malignant 4…”

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confidence: 99%

Malignant primary cardiac tumors

Simpson

Kumar

Okuno

et al. 2008

Cancer

263

107

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BACKGROUND. Primary cardiac sarcomas are uncommon. The authors undertook to review the Mayo Clinic's experience with primary cardiac sarcomas consisting of 34 patients seen over a 32‐year period. METHODS. The patient database at the Mayo Clinic was searched to identify patients with malignant tumors of the heart seen during the 32‐year period between 1975 and 2007. Thirty‐four patients with primary cardiac sarcomas were identified and their medical records reviewed for details pertaining to presenting symptoms, staging modalities, treatment approaches, and outcomes. RESULTS. Of the 34 patients, 17 were men and 17 were women. The median age was 44 years. The mean duration of symptoms at the time of diagnosis was 3.6 months. The most common histologic type was angiosarcoma (41%). The median follow‐up for the entire group was 12 months (range, 0‐61 months). The median survival for those who underwent a complete surgical excision was 17 months compared with 6 months for those in whom a surgical complete remission could not be achieved (P = .01). Patients with angiosarcoma had a lower survival compared with patients with other histologies (5 months vs 17 months; P = .01). The median survival of patients with metastatic disease was 5 months versus 15 months in patients without metastatic disease (P = .03 by the log‐rank test). CONCLUSIONS. Cardiac sarcomas remain a rare but lethal disease. Compared with extracardiac sarcomas, the prognosis for patients with cardiac sarcomas remains very poor. A complete surgical excision should be performed if possible. Innovative treatment strategies are required. Cancer 2008. © 2008 American Cancer Society.

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“…if necessary. 7 Difficult locations such as the retrocardiac pericardial space are accessible through complex means, including cardiectomy and "autotransplantation" following tumor resection. 8 Our case involved a tumor with mixed histopathologic features-myxomatous tissue within a majority of mature adipose tissue, a unique finding in the pediatric literature.…”

Section: Discussionmentioning

confidence: 99%