Primary Cardiac Tumors Causing Sudden Death: A Review of the Literature

Cina, Stephen J.; Smialek, John E.; Burke, Allen; Virmani, Renu; Hutchins, Grover M.

doi:10.1097/00000433-199612000-00001

Cited by 139 publications

(82 citation statements)

References 30 publications

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“…Rates of sudden death due to cardiac tumors is ∼0.06% in persons 34 years and younger. 15 Poor prognosis is associated with lesions involving the coronaries, cardiac valves, or ventricular outflow tracts. 2,5 Although serum laboratory investigations may offer some information, diagnostic imaging is the mainstay for diagnosis of cardiac tumors.…”

Section: Discussionmentioning

confidence: 99%

Febrile Illness in an Infant With an Intracardiac Inflammatory Myofibroblastic Tumor

et al. 2016

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We report a case of a child with a right ventricular inflammatory myofibroblastic tumor (IMT) who presented with fever, viral symptoms, and abdominal discomfort. Including this case, 49 intracardiac tumors have been previously reported in all age groups. The majority of intracardiac IMTs occur in pediatric patients, with approximately half presenting in children aged <12 months. Intracardiac IMTs are generally described as benign tumors; however, depending on their location, the initial presentation may involve heart failure or sudden death.1 In addition to cardiac signs and symptoms, the clinical presentation of IMTs may also include constitutional signs such as fever, anemia, and elevated inflammatory markers. This case report reviews the diagnosis and management of IMTs, as well as the histopathologic features of this rare tumor type. Clinicians should be aware of their clinical presentation because early diagnosis and treatment can significantly reduce morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Febrile Illness in an Infant With an Intracardiac Inflammatory Myofibroblastic Tumor

et al. 2016

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“…Until 1996, 120 cases of sudden death attributed to these tumors had been reported, 86% of them being histologically benign. However, the intracardiac location caused hemodynamic and conduction changes, resulting in sudden death 18 .…”

Section: Discussionmentioning

confidence: 99%

Right atrial lipoma

Pêgo‐Fernandes

Costa

Fernandes

et al. 2003

Arq. Bras. Cardiol.

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Primary cardiac tumors are rare, not easily clinically diagnosed, and differ in regard to clinical manifestations, location, morphology, size, and radiological findings 1 .The incidence of primary tumors of the heart and pericardium ranges from 0.02% to 0.28%, according to a series of autopsies reported by McAllister HA Jr 2 . On the other hand, neoplasias, mainly mammary and pulmonary neoplasias (that send more metastases to the heart), followed by leukemias and lymphomas are 10 to 40 times more frequent than primary cardiac tumors. Cardiac metastases are found in the autopsies of 10% of the patients who die from pulmonary cancer and of 25% of those with tumors in other organs. In children, cardiac tumors are rare, not exceeding 10% of all neoplasias in this age bracket 3 .Approximately 75% of the primary cardiac tumors are benign 4 , myxomas being the most common, followed by rhabdomyomas, lipomas, fibromas, and teratomas 3 . Cardiac lipomas, initially reported by Orth in 1886 5 , account for 8.4% of the primary tumors of the heart and pericardium. Until 1990, 63 had been reported 6 . According to the available literature, 25% of cardiac lipomas are intramyocardial, 25% are extracavitary of epicardial origin, and 50% are intracavitary of subendocardial origin -those of the right atrium are extremely rare 7 .In the recent literature, a case of intrapericardial lipoma in a 27-year-old female 8 and a case of right atrial lipoma in a 54-year-old male have been reported 9 . In 1994, Diamante et al 10 reported a peculiar case of epicardial lipoma that caused inversion of the left atrial auricle and partial obstruction of the drainage of the left pulmonary veins, leading to pulmonary and systemic arterial hypertension, cardiomegaly, and electrocardiographic changes. In a study of 50 cases of primary cardiac neoplasias by Fernandes et al 11 , only 1 lipoma was reported. Case ReportThe patient was a 48-year-old male who complained of high blood pressure and epistaxis for 2 months. He denied similar previous episodes. He also reported being an exsmoker (2 packs per day) for 20 years and denied alcoholism. His personal and familial antecedents were not relevant.At the time of the symptoms, the patient visited a cardiologist. Due to the nonspecificity of the symptoms, an echocardiography (7/2/98) was performed and revealed a right atrial tumor of 4.6x3.5 cm with characteristics of adipose tissue.The patient was referred to our service. On physical examination, he was in good general condition, eupneic, acyanotic, and had no fever. His blood pressure was 130/ 80mmHg, his heart rate was 60 bpm, and the rest of his physical examination was within the normal range.The laboratory tests showed a mild leukocytosis (13,900 cells/mm 3 ) with no deviation to the left. The remaining tests were within the normal range.The chest X-ray showed normal pulmonary transparency, normal hila, free diaphragmatic sinuses and cupula, and a normal cardiac image.The electrocardiography detected sinus rhythm of 72 bpm with deviation of the cardiac ...

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“…Primary cardiac haemangioma is an infrequent benign neoplasm which accounts for about 2% of all resected primary cardiac tumours [12,32,33]. The tumour is usually sporadic and may occur in patients of all age categories [34].…”

Section: Other Rare Cardiac Tumours and Tumour-like Conditionsmentioning

confidence: 99%

Surgical treatment of cardiac tumors - an overview and presentation of interesting cases

2011

Cardiovasc Med

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Primary Cardiac Tumors Causing Sudden Death: A Review of the Literature

Cited by 139 publications

References 30 publications

Febrile Illness in an Infant With an Intracardiac Inflammatory Myofibroblastic Tumor

Febrile Illness in an Infant With an Intracardiac Inflammatory Myofibroblastic Tumor

Right atrial lipoma

Surgical treatment of cardiac tumors - an overview and presentation of interesting cases

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