Primary cardiac sarcomas: Treatment strategies

Chan, Edward Y.; Ali, Aman; Zubair, M. Mujeeb; Nguyen, Duc T.; Ibarra-Cortez, Sergio H.; Graviss, Edward A.; Shapira, Oz M.; Ravi, Vinod; MacGillivray, Thomas E.; Reardon, Michael J.

doi:10.1016/j.jtcvs.2021.10.070

Cited by 15 publications

(16 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…reported their 25 years’ experience that patients who received multimodality treatment (any combination of surgery, radiation therapy, and chemotherapy) had an improved median survival compared with patients treated with surgery, radiation therapy, or chemotherapy only (P=0.05) ( 40 ). This was also reported in other studies ( 41 , 42 ). Saleh and colleagues showed that neoadjuvant chemotherapy followed by radical surgery is safe and effective strategy also in patients with right-sided heart sarcomas ( 43 ).…”

Section: Discussionsupporting

confidence: 91%

Geographic variation in malignant cardiac tumors and their outcomes: SEER database analysis

et al. 2023

View full text Add to dashboard Cite

IntroductionPrimary malignant cardiac tumors (PMCTs) are rare. Geographical distribution has been demonstrated to affect cancer outcomes, making the reduction of geographical inequalities a major priority for cancer control agencies. Geographic survival disparities have not been reported previously for PMCT and the aim of this study is to compare the prevalence and the long-term survival rate with respect to the geographic location of PMCTs using the Surveillance, Epidemiology, and End Results (SEER) research plus data 17 registries between 2000 and 2019.MethodsThe SEER database was queried to identify geographic variation among PMCTs. We classified the included states into 4 geographical regions (Midwest, Northeast, South and West regions) based on the U.S. Census Bureau-designated regions and divisions. Different demographic and clinical variables were analyzed and compared between the four groups. Kaplan Meier curves and Cox regression were used for survival assessment.ResultsA total of 563 patients were included in our analysis. The median age was 53 years (inter-quartile range (IQR): 38 - 68 years) and included 26, 90, 101, and 346 patients from the Midwest, Northeast, South, and West regions respectively. Sarcoma represented 65.6% of the cases, followed by hematological tumors (26.2%), while mesothelioma accounted for 2.1%. Treatment analysis showed no significant differences between different regions. Median overall survival was 11, 21, 13, and 11 months for Midwest, Northeast, South and West regions respectively and 5-year overall survival was 22.2%, 25.4%, 14.9%, and 17.6% respectively. On multivariate Cox regression, significant independent predictors of late overall mortality among the entire cohort included age (Hazard Ratio [HR] 1.028), year of diagnosis (HR 0.967), sarcoma (HR 3.36), surgery (HR 0.63) and chemotherapy (HR 0.56).ConclusionPrimary malignant cardiac tumors are rare and associated with poor prognosis. Sarcoma is the most common pathological type. Younger age, recent era diagnosis, surgical resection, and chemotherapy were the independent predictors of better survival. While univariate analysis revealed that patients in the South areas had a worse survival trend compared to other areas, geographic disparity in survival was nullified in multivariate analysis.

show abstract

Section: Discussionsupporting

confidence: 91%

Geographic variation in malignant cardiac tumors and their outcomes: SEER database analysis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…4–6,15 The most common sites for metastases include lungs, bone, liver, and brain. 4 Imaging at the time of initial diagnosis must include a whole-body positron emission tomography/computed tomography (CT) or CT of the chest, abdomen, and pelvis and MRI of the brain to check for metastatic sites. At the sites where metastatic disease is identified, we recommend regular imaging with the same modalities to assess response to treatment.…”

Section: Monitoring For and Management Of Metastasesmentioning

confidence: 99%

“…However, surgery remains the primary treatment modality when feasible. 4 Systemic therapy, independently and in combination with surgery, has shown improved survival outcomes in patients. 5,7,10 In this review, we attempt to highlight the strategies that we consider to be the 7 pillars of nonsurgical oncology approaches to the management of primary cardiac sarcoma.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Angiosarcomas account for about 40% of primary cardiac sarcomas, while other histologies include leiomyosarcoma, undifferentiated pleomorphic sarcoma, rhabdomyosarcoma, intimal sarcoma, and synovial sarcoma. [4][5][6][7][8][9] Primary cardiac sarcomas are commonly seen in a younger population in their 40s. 5 They are highly aggressive tumors with a median survival of 7 months.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The 7 Pillars of Nonsurgical Oncology Approaches to Primary Cardiac Sarcoma

Subramaniam,

Ravi

2024

Innovations�(Phila)

Self Cite

View full text Add to dashboard Cite

“… 2 We recently reported our updated series of 122 surgical resections for primary cardiac sarcoma at the 101st Annual Meeting of The American Association for Thoracic Surgery. 3 These were again young patients, with a mean age of 45.3 years. The majority of these cases had been originally operated on elsewhere and were referred to us after recurrence.…”

mentioning

confidence: 93%