Primary cardiac malignant fibrous histiocytoma with vulvar metastases: A case report

Abstract

Abstract. Malignant fibrous histiocytoma (MFH) occurring in the heart is rare. To the best of our knowledge, the current study was the first to report a case of left atrial MFH metastasizing to the vulva. A 37-year-old female presenting with a history of exertional dyspnea underwent echocardiography, which revealed a mass in the left atrium, with a short-wide stalk attached to the posterior wall, extending into the pericardium. Furthermore, the mass resulted in severe mitral stenosis during diastole. The tumor was excised together with a section of the left atrial wall. The initial diagnosis was a left atrial myxoma. However, post-operative frozen section histopathology results indicated a diagnosis of MFH. Following surgery, the patient received chemotherapy, however, vulvar metastases and left pleural effusions were identified after 1 month. Following surgical excision of the vulvar tumor and left thoracentesis, the patient began adjuvant chemotherapy. However, the patient succumbed due to local recurrence 6 months later.

Combined treatment for a large primary cardiac sarcoma: a case report

“…Mean patient survival period is approximately 1 year after diagnosis [2, 3]. Complete resection is the most recommended treatment for UPS [2–4], but is rarely accomplished in emergency cases because of the patients’ unstable condition and complex anatomical location of tumors upon initial examination.…”

Society for Cardiovascular Magnetic Resonance 2022 Cases of SCMR case series

“…Complete resection followed by adjuvant medical therapy offers the best outcomes. However, clear surgical margins are difficult to obtain, and recurrence remains a challenge [94] , [95] , [96] , [97] . Recurrence in our patient is noteworthy for the rapid rate of re-growth resulting in clinically significant obstruction during the two-week period between the TTE and CMR.…”