Primary Cardiac Lymphoma in an Immunocompetent 71-Year-Old Man

Montanaro, Claudia; Loiacono, Ferdinando; Fragasso, Gabriele; Cobelli, Francesco De; Foppoli, Marco; Margonato, Alberto

doi:10.14503/thij-14-4269

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…The incidence of PCL has been on the rise in association with acquired immunodeficiency syndromes and transplant recipients receiving immunosuppressive therapy [9]. PCL has been a rarely reported malignancy in immunocompetent individuals and is often not diagnosed until there are advanced clinical manifestations [10]. A cardiac neoplasm was not suspected as the cause for our immunocompetent patient's complete heart block until imaging was obtained.…”

Section: Discussionmentioning

confidence: 92%

Primary Cardiac Lymphoma Manifesting as Complete Heart Block

Usry

Wilson

Bush

2020

Case Reports in Cardiology

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Primary cardiac tumors are exceedingly rare with variable clinical manifestations. This case involves a patient presentation of symptomatic complete heart block and cardiac imaging revealing a right atrial mass invading the myocardium consistent with Burkitt lymphoma on histopathology. The patient received definitive bradytherapy with a pacemaker and chemotherapy for the primary cardiac lymphoma. After three cycles of chemotherapy, the right atrial mass regressed significantly with restoration of atrioventricular conduction and no pacing burden. Primary cardiac lymphomas infrequently manifest as atrioventricular block and this case highlights cardiac masses as a potential etiology when evaluating new conduction disturbances and bradyarrhythmias.

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Section: Discussionmentioning

confidence: 92%

Primary Cardiac Lymphoma Manifesting as Complete Heart Block

Usry

Wilson

Bush

2020

Case Reports in Cardiology

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“…PCLs typically present in immunocompromised and HIV-positive patients, as well as in patients having undergone heart transplantation or receiving immunosuppressive medications [8]. However, approximately 25 cases of PCL in immunocompetent patients have also been described [9].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment complications of primary cardiac lymphoma in an immunocompetent 28-year old man: a case report

Bonou¹,

Kapelios²,

Marinakos³

et al. 2019

BMC Cancer

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Background Primary cardiac lymphomas (PCL) represent extremely rare cardiac tumors which are accompanied by poor prognosis, unless they are timely diagnosed and treated. Case presentation Herein we present a 28-year-old, immunocompetent man who presented to our hospital due to progressively worsening symptoms and signs of superior vena cava syndrome. Multi-modality imaging demonstrated a large intracardiac tumor, which was proven, by biopsy, to be a PCL. The patient received targeted chemotherapy which led to total remission of his disease, with no relapse over a 15-month follow-up period. Conclusions Although PCLs are rare, they should always be kept in mind in the differential diagnosis of cardiac tumors. Timely diagnosis of PCLs and appropriate chemotherapy, alone or in combination with radiotherapy, seems to provide the best results.

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