Primary Cardiac Lymphoma in a Heart Transplant Recipient

Primary cardiac lymphoma

“…2) [16], although rare cases of T-cell [11,12], anaplastic [13,14], and plasmablastic [15] lymphomas have also been described. An association between primary cardiac CD30+ anaplastic B-cell lymphoma and EBV nucleic acid sequences positivity (in the malignant cells) has been described [14,17]. EBV RNA has also been found in tumor cells of plasmablastic PCL [15].…”

“…PCL occurs more frequently in immunocompromised patients [18], as in patients with AIDS [18], in subjects taking immunosupressive drugs [5], and in cardiac transplantation recipients [17]. However, there have been reports on PCL in immunocompetent subjects as well [10].…”

“…A clinical picture consistent with inferior vena cava [17,23,24] and superior vena cava compression syndromes [8,10,11,18,23,[25][26][27], and aortic stenosis [28] have also been reported. Rarely, PCL masquerading as constrictive pericarditis may also be found [29].…”

“…Leukocytosis and neutrophilia can be found in some patients with PCL [8,11,36]. Abnormal liver function tests have been observed in a few patients [8,17,22,23]. In this regard, a small rising in alkaline phosphatase, aspartame aminotransferase, alanine aminotransferase [2,8,22,46], and total bilirubin have been reported [2,46].…”

An Unusual Presentation of Post-transplant Lymphoproliferative Disorder Mimicking Vasculitis in Heart Transplantation

“…PTLD encompasses a diverse range of histologic patterns from lymphoid hyperplasia to frank lymphoma. 4 Within the heart, PTLD occurs as focal masses [5][6][7] and diffuse myocardial, valvular and epicardial infiltration. 8 -11 PTLD has also been described in the coronary artery intima.…”