Primary cardiac lymphoma

Primary Cardiac Triple-Hit Lymphoma

“…In the retrospective cohort study using the Surveillance, Epidemiology, and End Results program for 184 patients with PCL, Yin, et al reported that chemotherapy decreased the hazard of death by 60% (aHR, 0.4; 95% CI, 0.23-0.69; P < 0.001). 16) In this case, the decision to excise the mass was urgently made due to the initial suspicion of myxoma and to the hemodynamic obstruction and mobility of the cardiac mass. Chemotherapy was not possible in this case because the patient refused the treatment.…”

Case Report: Cardiac Involvement by Lymphoma: Rare but Heterogeneous Condition With Challenging Behaviors

“…PCL is more often an aggressive lymphoma, diffuse large B cell lymphoma (DLBCL) being the most common histology (2)(3)(4)(5); other histologies have been more rarely reported (6). Diagnosis of PCL requires histologic sample, which can be obtained by endomyocardial biopsy or even by surgical resection, when debulking is clinically needed (7). In selected cases, cytological examination of pericardial fluid may allow to omit a biopsy approach, if monoclonal lymphocytes are found by flow cytometry analysis.…”

Commentary: Don't mess with primary cardiac lymphoma

“…However, even if this is the case, the principal findings of the study are important: Surgical management of primary cardiac lymphoma was not associated improved survival, whereas chemotherapy was associated with improved survival. 1 Other studies evaluating this rare disease are limited by heterogenous patient populations, small institutional series, or case reports. Perhaps the most robust data can be found in a meta-analysis from Petrich and colleagues 2 in the medical oncology literature.…”