Primary cardiac disease in systemic lupus erythematosus patients: protective and risk factors--data from a multi-ethnic Latin American cohort

García, Mercedes; Alarcón, Graciela S.; Boggio, Gabriela Susana; Hachuel, Leticia Susana; Marcos, Ana Isabel Sánchez; Marcos, Juan Carlos; Gentiletti, Silvana; Caeiro, Francisco; Sato, Élcio Hideo; Borba, Eduardo F.; Brenol, João Carlos Tavares; Massardo, Loreto; Molina-Restrepo, José Fernando; Vásquez, Gloría; Guibert-Toledano, Marlene; Barile-Fabris, Leonor; Amigo, Mary‐Carmen; Huerta-Yanez, G. F.; Cucho-Venegas, Jorge M.; Chacón-Díaz, Rosa; Pons-Éstel, Bernardo A

doi:10.1093/rheumatology/keu011

Cited by 34 publications

(24 citation statements)

References 42 publications

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“…20 We, however, could not find any prospective association of CNS involvement with pericarditis or pleurisy in any of our analysis.…”

Section: Epidemiology and Outcomescontrasting

confidence: 57%

“…The cross-sectional analysis includes all patients, and thus has Lupus Science & Medicine 20 reported that 'primary cardiac disease', including pericarditis (81.2% of all cases), was associated with African-Latin American ethnicity. Because serositis had been thought to be one pathogenic mechanism, it is quite surprising (and not understood) why pericarditis is associated with African-American ethnicity, whereas pleurisy is not.…”

Section: Discussionmentioning

confidence: 99%

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Associates and predictors of pleurisy or pericarditis in SLE

Ryu

Petri

2017

Lupus Sci Med

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Background/PurposeSerositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis. The aim of this study is to analyze associates and predictors of pleurisy versus pericarditis in Caucasians and African Americans with SLE.Methods2,390 SLE patients in the Hopkins Lupus Cohort were analyzed for demographic, clinical and serologic associates of pleurisy or pericarditis, defined using the SELENA revision of the SLE Disease Activity Index (SLEDAI). The cross-sectional and prospective study using either univariate or multivariate analysis were performed to evaluate the associates of serositis in SLE. We reported associates with a p-value of less than 0.05 for pleurisy or pericarditis.Results43% had pleurisy and 22% had pericarditis. African-American ethnicity was a predictive factor for new pericarditis. Hemolytic anemia, proteinuria, lymphadenopathy and anti-Sm were predictive only of pericarditis, whereas pulmonary fibrosis and GI infarction were predictive only of pleurisy. Fever, Raynaud’s syndrome, and anti-DNA were predictors for both pericarditis and pleurisy.ConclusionOur study provides further insights into the associates of pleurisy and pericarditis in SLE. Predictors of pleurisy and pericarditis are shown for the first time. The long term consequences from the cross-sectional analysis gives a lesson that serositis in SLE should not be considered benign.

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“…20 We, however, could not find any prospective association of CNS involvement with pericarditis or pleurisy in any of our analysis.…”

Section: Epidemiology and Outcomescontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Associates and predictors of pleurisy or pericarditis in SLE

Ryu

Petri

2017

Lupus Sci Med

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“…4,12,37 Anti-SSA/SSB antibodies have been found to be associated with cardiac involvement in cSLE 37,38 and anti-malarial therapy protects from future SLE-associated cardiac diseases. 39 …”

Section: Cardiac Manifestationsmentioning

confidence: 99%

“…37,39 The incidence of cSLE-associated pericarditis ranges from 10-38%. 37,[39][40][41] The clinical presentation, electrocardiogram (EKG) and echocardiographic (ECHO) findings of pericarditis due to cSLE are indistinguishable from those from other causes. Tachycardia, fever, substernal chest discomfort, positional chest pain, diminished heart sounds and rarely friction rub are the typical presenting symptoms.…”

Section: Pericarditismentioning

confidence: 99%

Organ involvement other than lupus nephritis in childhood-onset systemic lupus erythematosus

Huggins

Holland

Brunner

2016

Lupus

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In this review we critically analyze pulmonary, gastrointestinal and cardiac manifestations of childhood-onset systemic lupus erythematosus (cSLE). Clinical manifestations of these organ systems may be the initial manifestation of cSLE; frequently occur with very active cSLE; and are potential life-threatening manifestations often presenting to the emergency department and requiring admission to the intensive care unit. Early recognition and treatment of the pulmonary, gastrointestinal and cardiac manifestations of cSLE will result in improved prognosis and better outcomes. Lupus (2016) 25, 857-863.

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“…Cardiovascular diseases are frequent in SLE patients. There were regional and racial differences in cardiac manifestations and related risk factors in patients with SLE [6]. The pathological and clinical characteristics of SLE have not been completely elucidated until now.…”

Section: Introductionmentioning

confidence: 99%

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

et al. 2018

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Objective To investigate cardiac manifestations and the risk factors in Han Chinese patients with systemic lupus erythematosus (SLE). Methods Seven hundred fifty SLE patients who were hospitalized at our department were recruited in the present study. The patients were divided into two groups-those with or without cardiac manifestations. Cardiac manifestations in those SLE patients, such as pericarditis, myocarditis, heart valve disease, arrhythmia, were analyzed. The risk and protective factors of cardiac diseases in patients with SLE, as well as the predictors of mortality, were assessed, respectively. Results In all 750 SLE patients, there were 339 (45.20%) patients suffered from one or more cardiac manifestations, involving pericarditis in 9.5%, myocarditis in 5.7%, heart valve disease in 15.6%, arrhythmia in 16.67%, and cardiovascular diseases (CVD) in 14%. 15.7% of SLE patients were accompanied with pulmonary arterial hypertension (PAH), of which 13.7% were mild, 1.2% were moderate, and 0.8% were severe. No significant differences were found between the two groups in age, disease duration, gender, antibody, and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). The incidence of pericarditis, heart valve disease, arrhythmia, and PAH was positively correlated with age. The incidence of arrhythmia, CVD, and PAH was correlated with SLEDAI. PAH and myocarditis were the risk factors of mortality in SLE patients with disease duration ≤ 10 years (P = 0.034 and 0.001, respectively). Conclusion Cardiac involvement is common in Han Chinese SLE patients and associated with age and disease activity. PAH and myocarditis are the risk factors of mortality in SLE.

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Primary cardiac disease in systemic lupus erythematosus patients: protective and risk factors--data from a multi-ethnic Latin American cohort

Cited by 34 publications

References 42 publications

Associates and predictors of pleurisy or pericarditis in SLE

Associates and predictors of pleurisy or pericarditis in SLE

Organ involvement other than lupus nephritis in childhood-onset systemic lupus erythematosus

Cardiac manifestations of Han Chinese patients with systemic lupus erythematosus: a retrospective study

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