Primary Carcinoma of the Lungs

Fried, B. M.

doi:10.1001/archinte.1925.00120070006001

Cited by 45 publications

(3 citation statements)

References 2 publications

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“…Non small cell lung cancer (NSCLC) generally yields brain metastases which are only moderately responsive to whole brain radiation therapy (WBXRT). For over 60 years, surgical resection of a brain metastasis from lung primary has been shown to be effective at prolonging functional survival [12].…”

Section: Introductionmentioning

confidence: 99%

Surgical resection of brain metastases from lung cancer

1996

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The role of surgical resection for brain metastases is evolving. The most common primary for brain metastases is lung; in the US in 1992, for example, there were nearly 40,000 deaths with symptomatic brain metastases from lung cancer. We reviewed a series of 25 consecutive patients with non small cell lung cancer (NSCLC) undergoing open resection of one or more symptomatic brain metastases to consider the role of open resection. Twenty-three of the 28 resected lesions were 3 cm or greater in diameter; 19 were solid and nine cystic. Surgical adjuncts included (where indicated): stereotactic biopsy, cyst drainage, and craniotomy; intra-operative ultrasound; and intra-operative evoked potential mapping of the sensorimotor area. Six patients underwent thoracotomy for resection of the lung primary (in all but one case, prior to craniotomy). Except for two patients who had whole brain radiation therapy (WBXRT) prior to referral to Neurosurgery, all patients underwent WBXRT (30 to 60 Gy) postoperatively. The mean survival from date of craniotomy was 13.1 months, with two patients still alive at ten and seventeen months post-craniotomy. Survival comparisons which were significantly different included (1) lung surgery versus no lung surgery (25.7 months versus 9.1 months, P < 0.001), and (2) metachronous presentation of the lung primary and brain metastasis versus synchronous presentation (17.6 months versus 9.5 months, P = 0.025). Survival comparisons which were not significantly different included single versus multiple metastases, complete versus incomplete resection, adenocarcinoma versus large or squamous or cell histology, supratentorial versus infratentorial location, solid versus cystic metastasis, and age < or = 60 years versus > 60 years. These results, when compared with the literature on brain metastases, suggest that aggressive resection of symptomatic metastases from lung cancer (even if multiple) can improve functional survival over conservative management, and that small, asymptomatic lesions are well-controlled by WBXRT. They also confirm the previous finding that surgical treatment of both the lung primary and the brain metastases may afford the greatest period of functional survival for these patients.

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Section: Introductionmentioning

confidence: 99%

Surgical resection of brain metastases from lung cancer

1996

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“…Cases in which livers with metastatic growths have attained great weights (13 between 5,000 and 10,000 g., and 7 exceeding 10,000 g.) are referred to by Willis (1952). The livers reported by Kikuth (1925) and Fried (1925) weighed 11,800 g. and 6,400 g. respectively, and were from cases of lung carcinoma.…”

Section: Commentmentioning

confidence: 98%

Optimum Injection Volume for Intramuscular Streptomycin Sulphate

Stradling¹,

Kreeger²

1954

BMJ

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The phenomenon of rapid alternation of clinical syndromes among allergic individuals has long been recognized-for instance, asthma and eczema in young children. It would appear that the antihistamines are capable of provoking such an alternation. Tomlinson (1948) and Harris (1948) cite cases in which eczema supervened when hay-fever was treated with diphenhydramine hvdrochloride. Frankland (1949) refers to the onset of asthma towards the end of the pollen season in patients who have been treated with antihistamines.The records of nine patients who exhibited this phenomenon are given below. They were seen during the course of investigation and treatment of 3,000 cases of allergic rhinopathy (including hay-fever) in the past four years. In each case cited antihistamine therapy produced relief of the symptom treated, coincidentally with the appcarance of asthma. In most cases this effect was reversible, and cessation of this therapy restored the status quo ante. Pollen was usually but not invariably a major aetiological factor. CASE REPORTS Case 1.-A woman aged 37 had had intermittent vasomotor rhinitis for 13 years; it was perennial, but worse in the summer months. Skin sensitivity to house dust and pollens was demonstrated. A first and only attack of asthma occurred with great severity immediately after taking antazoline tablets. This has not recurred, and the patient has refused to take further antihistamines.Case 2.-A girl aged 8 had had atopic eczema since infancy and seasonal hay-fever for the last three summers, but no asthma. In the summer of 1950 she took mepyramine maleate on two or three occasions, and each time an attack of asthma supervened. When the drug was discontinued no further asthma occurred. Skin sensitivity was demonstrated to pollens only.Case 3.-A woman aged 29 had had vasomotor rhinitis and asthma for five years. After a course of hyposensitization treatment in 1948 and 1949 the asthma had practically disappeared, but the vasomotor rhinitis persisted though improved. In April, 1950, she took promethazine hydrochloride for the first time, with immediate improvement of the tnasal condition, but severe asthma occurred within three days. Cessation of the drug brought about complete relief of asthma but recurrence of vasomotor rhinitis. She has repeated the test on four further occasions (using different antihistamines) with identical results each time-on the third night of treatment she develops asthma.Case 4.-A woman aged 30 had had morning rhinorrhoea for many years which cleared completely during pregnancy three years ago but recurred with increased severity and frequency a year later. Mepyramine maleate relieved the nasal condition, but within a day or two produced moderately severe asthma for the first time. The as.hma has persisted in a mild form though antihistamines have been discontinued. Pollen sensitivity was demonstrated.Case 5.-A woman aged 50 had seasonal hay-fever at age 21 which was treated and relieved by cauterization. A severe recurrence in the summer of 1949 was treated ...

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“…He in 1915 was able to tabulate from the literature only 16 cases of operations for primary carcinoma of the liver. Out of these 16, 4 patients died from various causes within sixteen days, 6 patients had recurrences in periods varying from two months to eight years, while 6 patients were alive and well from three t o seven pears subsequent t o their operation.…”

Section: Operabilitymentioning

confidence: 99%

Primary carcinoma of the liver: With report of case successfully treated by partial hepatectomy

Abel

1934

Journal of British Surgery

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ASSISTANT SUKCEON, CANCLR HOSPITAL (FREE), LONDON.CAWIXOJIA occurs only very rarely as a primary disease of the liver, in markcd cbontrast to sccondary growths, which are extremely common in this organ. Up t o sixty years ago observers believed the reverse t o be thc case, and, in spite of Virchow's warning in regard t o the importance of searching for a primary focus with meticulous care, many cases were reported which were later discredited.

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Primary Carcinoma of the Lungs

Cited by 45 publications

References 2 publications

Surgical resection of brain metastases from lung cancer

Surgical resection of brain metastases from lung cancer

Optimum Injection Volume for Intramuscular Streptomycin Sulphate

Primary carcinoma of the liver: With report of case successfully treated by partial hepatectomy

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