Primary Carcinoma of The Liver

Berman, Charles L.

doi:10.1016/s0065-230x(08)60409-1

Cited by 143 publications

(54 citation statements)

References 78 publications

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“…The appearances were like those described elsewhere (Berman, 1951;Ninard, 1950;Davies, 1952) and a repetition of the details is not necessary. No unusual features were observed in Uganda except that the tumours were very large on the average.…”

Section: Gross Pathologysupporting

confidence: 59%

“…Because the ultimate objective is to find aetiological factors, special attention was paid during this study to the histopathogenesis of the lesions and to possible causative agents of both diseases. It is known from Africa (Berman, 1951) and other countries (Steiner, 1954) that where the frequency of liver cancers is high, the disease often comes on early in life. The higher yield of tumours and the possible shortened induction time suggest that the aetiological factors are intensified.…”

mentioning

confidence: 99%

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Cirrhosis and Primary Liver Carcinoma in Uganda Africans

Steiner¹,

Davies²

1957

Br J Cancer

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(Knowelden, 1957) suggest that the incidence of liver cancer in Uganda males is two and a half times that of a corresponding Danish population but that an elevated frequency in Uganda females could not be shown. Relative to other malignant tumours, liver cancers ranked fourth, being exceeded only by those of the uterine cervix, skin and penis (Davies, 1957). Carcinoma of the liver thus is an important and major neoplastic disease in Uganda. Most cancers arise in cirrhotic livers so that the cirrhosis also demands study.This report will attempt to characterise the pathological features both of cirrhosis and of cancer in Uganda Africans. Because the ultimate objective is to find aetiological factors, special attention was paid during this study to the histopathogenesis of the lesions and to possible causative agents of both diseases. It is known from Africa (Berman, 1951) and other countries (Steiner, 1954) that where the frequency of liver cancers is high, the disease often comes on early in life. The higher yield of tumours and the possible shortened induction time suggest that the aetiological factors are intensified. A study of the exaggerated situation might reveal cause-and-effect relationships not apparent where the frequency is low.Some special problems given consideration included the following:-1. Is the high incidence of liver cancer due merely to more cases of the usual morphological types or do new varieties enter the picture ?

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Section: Gross Pathologysupporting

confidence: 59%

mentioning

confidence: 99%

Cirrhosis and Primary Liver Carcinoma in Uganda Africans

Steiner¹,

Davies²

1957

Br J Cancer

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“…The incidence of ruptured hepatoma has been given variously as 8% (Berman, 1951), 10-2% (Balasegaram, 1968), and 12.8% (Ong et al, 1965). The present series shows an incidence of 14-5%.…”

Section: Control Of Haemorrhage By Packingmentioning

confidence: 99%

Spontaneous rupture of hepatocellular carcinoma

Ong¹,

Chu²,

Yu³

et al. 1965

British Journal of Surgery

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“…If persistence of HBV does play a role in the aetiology of PHC, two possible mechanisms may be considered. Failure to clear the virus after an attack of acute hepatitis is known in some cases to lead to chronic active hepatitis and cirrhosis (Wright, McCollum and Klatskin, 1969;Sherlock et at., 1970), and PHC not infrequently develops in livers which are cirrhotic (Berman, 1951;MacDonald, 1956;Lin, 1970). HBsAg has been found in association with PHC in the absence of cirrhosis so that, alternatively, the virus may be directly oncogenic.…”

Section: Methodsmentioning

confidence: 99%