Primary Carcinoma of the Gallbladder

Piehler, Jeffrey M.; Crichlow, Robert W.

doi:10.1001/archsurg.1977.01370010028005

Cited by 155 publications

(216 citation statements)

References 14 publications

(1 reference statement)

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“…The case reported here had a very long interval from diagnosis of RCC metastasis to operation (12 years), and the removed specimen measured 2.3 cm. RCC metastases to the gallbladder have a low incidence of concomitant gallstone disease [8,18,19]. There is certain variability in the histological findings of gallbladder metastasis from RCC.…”

Section: Discussionmentioning

confidence: 99%

“…There is certain variability in the histological findings of gallbladder metastasis from RCC. The majorities of metastases has a polypoid or pedunculated morphology and often begin as a submucosal nodule that eventually becomes pedunculated [8,18,20]. In this case metastastic gallbladder carcinoma may resemble primary carcinoma of the gallbladder.…”

Section: Discussionmentioning

confidence: 99%

“…In this case metastastic gallbladder carcinoma may resemble primary carcinoma of the gallbladder. Metastatsis may be limited to the muscle layer and perimuscular connective tissue and doesn't necessarily involve the mucosa [6,8,18,21]. In immunohistochemistry, primary carcinoma of the gallbladder is positive for CK7 and CEA, while metastatic RCC is negative for these antigens [22].…”

Section: Discussionmentioning

confidence: 99%

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Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Mitsimponas¹

2017

Ann Hematol Oncol

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Isolated gallbladder metastasis from renal cell carcinoma is a very rare clinical entity with a significant male predominance. Until now, only 22 cases have been reported in the medical literature. Most cases occurred after very prolonged disease-free intervals. We report a case of metachronous isolated gallbladder metastasis of 15 mm size in a 72 yr old gentleman, 12 years after subtotal nephrectomy of the upper pole of the right kidney for clear cell renal cell carcinoma. At the time of diagnosis, the patient suffered from concurrent aggressive B-cell non-Hodgkin's lymphoma which was treated aggressively, including autologous bone marrow transplantation. Gallbladder resection was performed after treatment of the hematological malignancy. Small polypoid structures in the gallbladder of patients with antecedents of renal cell carcinoma should prompt surgical resection even if the size in ultrasound does not reach internationally accepted intervention thresholds for benign gall bladder polyps.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Mitsimponas¹

2017

Ann Hematol Oncol

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“…In a review of the literature up to 1978, Piehler and Crichlow reported only a 5 % 5-year survival and a median survival of 5 to 8 months for 5,836 cases. Even for the 25 % who were treated by resection with curative intent, only 16.5 % survived 5 years [3].…”

Section: Introductionmentioning

confidence: 99%

Resection After Neoadjuvant Chemotherapy in Advanced Carcinoma of the Gallbladder: a Retrospective Study

Selvakumar

Zaidi

Pande

et al. 2015

Indian J Surg Oncol

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Although rare over most of the world, Gallbladder cancer is very common in northern india. A delayed presentation, aggressive nature,lack of randomised trials and a poor prognosis have all contributed to the nihilistic halo encircling gallbladder cancer. None of the advances in oncology have been exploited enough to shatter the nihilistic halo. In this background we sought to analyze if the addition of neoadjuvant chemotherapy had any impact on the resectability, overall and disease free survival in patients with advanced carcinoma of the gallbladder. We reviewed the records of all patients who underwent surgery for carcinoma of the gall bladder from 2004 to 2010 at our institute retrospectively. Twenty-one patients received neoadjuvant chemotherapy and subsequently taken up for surgery. Outcome analysis of these 21 patients were done by Kaplan meier method and graphs plotted. Out of the 21 patients who were taken up for surgery after neoadjuvant chemotherapy, fourteen patients underwent R0 resection (Group 1). Seven patients had been rendered inoperable on exploration (Group 2). Thus about 66.67 % of patients deemed resectable after neoadjuvant chemotherapy on imaging underwent R0 resection. The mean overall survival of the group 1 was 42.8 months versus 6.6 months of group 2(Hazard Ratio: 3.42). Neoadjuvant chemotherapy improves resectability in some patients with unresectable gall bladder cancer. Resection after neoadjuvant chemotherapy is feasible and may improve survival in a select group of patients. However randomized studies are required to establish its definitive role.

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“…1 With an overall 5-year survival rate of o5%, GC is a highly lethal malignancy with very poor prognosis. 2 Most of GCs were diagnosed at a very late stage because of the lack of symptoms and non-specific symptoms of early-stage tumors. 1,3 Although the incidence of GC is relatively rare compared with other cancers, higher incidences of GC have been reported in certain geographical regions including India, Pakistan, Ecuador, Korea and Japan.…”

Section: Introductionmentioning

confidence: 99%

A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population

et al. 2012

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Gallbladder cancer (GC) is a relatively uncommon cancer with higher incidence in certain areas including Japan. Because of the difficulty in diagnosis, prognosis of GC is very poor. To identify genetic determinants of GC, we conducted a genome-wide association study (GWAS) in 41 GC patients and 866 controls. Association between each single-nucleotide polymorphism (SNP) with GC susceptibility was evaluated by multivariate logistic regression analysis conditioned on age and gender of subjects. SNPs that showed suggestive association (Po1Â10 À4 ) with GC were further examined in 30 cases and 898 controls. SNP rs7504990 in the DCC (deleted in colorectal cancer, 18q21.3) that encodes a netrin 1 receptor achieved a combined P-value of 7.46Â10 À8 (OR¼6.95; 95% CI¼3.43-14.08). Subsequent imputation analysis identified multiple SNPs with similarly strong associations in an adjacent genomic region, where loss of heterozygosity was reported in GC and other cancers. Reduced expression of DCC was indicated to be associated with the poorly differentiated histological type, increased proliferation and metastasis through loss of adhesiveness. However, due to the limited sample size investigated here, further replication study and functional analysis would be necessary to further confirm the result of the association. INTRODUCTIONGallbladder cancer (GC) is the most common malignancy of the biliary tract and the fifth most common cancer of the gastrointestinal tract. 1 With an overall 5-year survival rate of o5%, GC is a highly lethal malignancy with very poor prognosis. 2 Most of GCs were diagnosed at a very late stage because of the lack of symptoms and non-specific symptoms of early-stage tumors. 1,3 Although the incidence of GC is relatively rare compared with other cancers, higher incidences of GC have been reported in certain geographical regions including India, Pakistan, Ecuador, Korea and Japan. 4 In addition, the prevalence of GC is known to be three times higher in women than in men. 5 Although several clinical risk factors of GC such as gallstones, cholecystitis, porcelain gallbladder, gallbladder polyps, anomalous panreatobiliary duct junction and obesity have been indicated, 1,6 etiology of GC is largely unknown. Only few somatic genetic changes including mutations in K-ras, TP53 and p16 Ink4 /CDKN2 as well as loss of heterozygosity at several chromosomal regions harboring known or putative tumor-suppressor genes have been reported in GCs. 5,7 Hence, identification of novel genetic factors associated with susceptibility to GC should

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Primary Carcinoma of the Gallbladder

Cited by 155 publications

References 14 publications

Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Isolated Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature

Resection After Neoadjuvant Chemotherapy in Advanced Carcinoma of the Gallbladder: a Retrospective Study

A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population

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