Primary Carcinoma of the Female Urethra

Bracken, R. Bruce; Johnson, Douglas E.; Miller, Lowell S.; Ayala, Alberto G.; Gómez, Jesús Jiménez; Rutledge, Felix N.

doi:10.1016/s0022-5347(17)58741-8

Cited by 82 publications

(13 citation statements)

References 8 publications

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“…Among reported complications from RT, the most common include strictures, necrosis, fistulas, and chronic oedema . In female PUC, in addition to anatomical location and clinical stage, the size of the primary tumour has been found to correlate with outcomes . Disease‐specific survival is highest in tumours of the anterior urethra, and decreases in more posteriorly located tumours and is even lower when the entire urethra is involved.…”

Section: Disease Course and Prognostic Factorsmentioning

confidence: 99%

Management of advanced primary urethral carcinomas

et al. 2014

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Primary urethral carcinoma (PUC) is a rare malignancy accounting for <1% of genitourinary cancers, with a predilection for men and African-Americans. The sites and histology of urethral carcinoma vary by gender and anatomical location. Squamous cell carcinoma is most common among both genders but adenocarcinomas are noted in 15-35% of cases among women. Obstructive or irritative symptoms and haematuria are common modes of presentation. Clinical evaluation includes cystourethroscopy with biopsy and examination under anaesthesia. Magnetic resonance imaging provides a highly effective method to image the primary tumour while defıning the potential involvement of surrounding structures. Most tumours are localised, with regional metastases to nodal sites seen in up to 30% of cases in both genders, while distant metastases at presentation are rare (0-6%), but occur in up to 40% of cases with recurrent disease. Among men, the two most important prognostic factors are disease location and stage. Low-stage tumours (T1-2) and tumours involving the fossa navicularis or the penile urethra have a better prognosis than higher stage tumours (>T2 or N+) and lesions involving the bulbomembranous urethra. In women, in addition to stage and location, the size of the tumour has also prognostic implications. While surgery and radiation therapy (RT) are of benefit in early stage disease, advanced stage PUC requires multimodal treatment strategies to optimise local control and survival. These include induction chemotherapy followed by surgery or RT and concurrent chemoradiation with or without surgery. The latter strategy has been used successfully to treat other human papillomavirus-related cancers of the vagina, cervix and anus and may be of value in achieving organ preservation. Given the rarity of PUC, prospective multi-institutional studies are needed to better define the optimal treatment approach for this disease entity.

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Section: Disease Course and Prognostic Factorsmentioning

confidence: 99%

Management of advanced primary urethral carcinomas

et al. 2014

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“…[17] The prognosis of urethral tumors in woman depends on the size, stage, and anatomic location patient comorbidities, the type of diversion, as well as the presence or absence of systemic disease. [1,4,18,19] Large tumor size is associated with poor prognosis. According to most studies, the women treated with radiation therapy for distal PUCs seem to have similar survival outcomes compared with those treated with surgery.…”

Section: Discussionmentioning

confidence: 99%

Urethral adenocarcinoma with bilateral iliac and inguinal lymph nodes which revelead by urethra ectropion in 67-year-old woman: A case report

Soumanou¹,

Avakoudjo²,

Gandaho³

et al. 2018

CRCP

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We reported a case of urethral adenocarcinoma in a 67-year-old woman who was admitted for difficulty voiding, irritative voiding symptoms, bloody urethral discharge and urinary incontinence. Physical examination was realised by gyneacologist and conclued to urological pathology. Urological examination was showed urethral ectropion which was bleeding. She had no fewer, no pelvic pain even less loss weight. Her general state was satisfactory. The lymph nodes of right side inguinal were felt. Computed imaging was showed involvement of right side bladder and bilateral iliac inguinal lymph nodes. Urethral ectropion biopsy anatomopathological screening was conclued to clear cell adenocarcinoma but CIS lesions were not found. The tumor staging was T3N2M0. A radiotherapy was perfomed. The patient was improvement of voiding symptoms and decrease lymph nodes size. Primary urethral carcinomas are rare pathology especially in the woman. Several histological types exist. However, chemotherapy and radiotherapy are very effective on very advanced stages. This cancer may be revealed by an urethral ectropion in a year-old woman.

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“…Sind die Patientinnen medizinisch inoperabel, so ist eine Brachytherapie sinnvoll. Die Prognose ist relativ schlecht; in einer relativ großen Fallzusammenstellung wird von 32% Fünfjahresgesamtüberleben berichtet [68], ein Radiotherapeut berichtet über 42% [72].…”

Section: Karzinome Der Urethraunclassified

Treatment of the vulvar and vaginal carcinoma

Schnürch¹

2001

Der Gynäkologe

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Primary Carcinoma of the Female Urethra

Cited by 82 publications

References 8 publications

Management of advanced primary urethral carcinomas

Management of advanced primary urethral carcinomas

Urethral adenocarcinoma with bilateral iliac and inguinal lymph nodes which revelead by urethra ectropion in 67-year-old woman: A case report

Treatment of the vulvar and vaginal carcinoma

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