Primary carcinoma of the fallopian tube

Abstract

Among patients with cancer of the uterine adnexa in the 3 Danish Radium Centres, 38 were found to have tubal cancer. The diagnosis is difficult; the most important factor in early recognition is to bear in mind the possibility of tubal cancer when dealing with patients in the high‐incidence age group. During recent years, the incidence of the disease has been increasing. Age distribution, the side affected, and sterility were in accordance with previous findings. The prognosis depends more upon the clinical determination of spread of the disease at diagnosis than upon histologic grade. Exploratory laparotomy, which permits the diagnosis to be made on the operating table and the surgical procedure to be adapted accordingly, affords the best prognosis, if surgery is supplemented by high‐voltage irradiation. Since the introduction of high‐voltage therapy, there has been an increased 2‐1/2 year survival and an extension of the period without recurrence.

Mycoplasma Effects on SV40 Transformation of Human Amnion Cells

“…The reproducible SV40 transformation of human epithelial amnion cells in vitro and the characteristics of the strains of transformed cells during subcultivation, have been reported previously (1)(2)(3)(4). Since we have established that mycoplasma infection may affect spontaneously transformed amnion cells of the FL line, causing changes in morphology and growth ( 5 ) , in chromosome numbers and abnormalities (6)(7)(8), 2nd in tumor-producing capacity (9), it seemed pertinent to investigate possible effects of mycoplasma on SV40 transformation of amnion cells.…”

“…were considerably reduced ( 1 : 2 or 1 : 3 ) compared to SV40 transformed amnion strains in general (2,4,13). A most unusual SV40 production picture was observed.…”

“…It has been identified as a strain of mycoplasma fermentans (PG-18) by Dr. M. Barile, Division of Biologics Standards, National Institutes of Health, Dr. J. G. Tully, Laboratory of Bacterial Diseases, National Institutes of Allergy and Infectious Diseases, and Dr. Donald Armstrong, Sloan-Kettering Institute. The mycoplasma strain received many tissue culture passages as an experimental contaminant of FL cells and the derived, modified cell lines (5)(6)(7)(8)(9). For infection of amnion cultures in the present experiments, the mycoplasma was subcultured several times in BYE broth (10) to prevent the introduction of foreign cell types into the experimental cultures.…”

“…Since we have established that mycoplasma infection may affect spontaneously transformed amnion cells of the FL line, causing changes in morphology and growth ( 5 ) , in chromosome numbers and abnormalities (6)(7)(8), 2nd in tumor-producing capacity (9), it seemed pertinent to investigate possible effects of mycoplasma on SV40 transformation of amnion cells.…”

In vitro derived mouse A9 cell clones differing in malignancy: analysis by somatic cell hybridization with YACIR lymphoma cell clones.

“…It has been reported that a reduction in the malignancy of cells followed a mycoplasma infection that was cured (22). Another reported effect of mycoplasma was to increase dramatically the cloning efficiency of BHK21/C13 hamster cells in agar (23).…”