Primary cancer of the sphenoid sinus—A GETTEC study

Abstract

Early CT and MRI should be performed when facing aspecific, rhinological, or neuro-ophtalmological symptoms. Cranial neuropathies indicate a worse prognosis. Surgery, including debulking surgery, may be preferred to combined modality treatments without surgery. Its apparently favorable impact on prognosis would need to be tested in homogenous histological groups of patients, which is impossible because of the rarity of the disease. Highly conformal radiotherapy (adjuvant or definitive) should be encouraged and optimized with concurrent chemotherapy in advanced stages. Aggressive multidisciplinary management including surgery, chemotherapy, and radiotherapy should be encouraged and adapted on histology and tumor extensions. Progress is still warranted to improve outcomes.

Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

“…The usually well developed dot-like to punctate keratin immunoreactivity and strong, diffuse synaptophysin, chromogranin, CD56, and NSE reactivity should help to differentiation between STACC and neuroendocrine carcinoma. Importantly, CD117 is positive in both tumors, while CK7 is negative in neuroendocrine carcinomas and strongly positive in most STACC [29,108,150]. Epithelial-myoepithelial carcinoma usually has a well defined biphasic appearance, with a dual population.…”

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis

“…[6][7][8][17][18][19][20][21][22][23][24][25][26][27][28] The median age of the patients was 50 years (range, 38 to 55 years). The median follow-up period was 60 months (range, 32 to 100 months).…”

Sphenoid Sinus Carcinoma Mimicking Retrobulbar Optic Neuritis

“…Despite the advancements in the diagnosis and treatment methods, the prognosis remains poor, with a two-year survival rate for patients with squamous cell carcinomas ranging between 7% and 44%. 1,3,4 Favorable prognostic indicators include confinement of the tumor to the sphenoid sinus, absence of the neuro-ophthalmic involvement, and negative surgical margins. [1][2][3] Declaration of interest: The authors report no conflicts of interest.…”

“…1,3,4 Favorable prognostic indicators include confinement of the tumor to the sphenoid sinus, absence of the neuro-ophthalmic involvement, and negative surgical margins. [1][2][3] Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.…”

“…In 23 primary sphenoid sinus cancers seen in six centers in 16 years, the presenting symptoms were headache (35%), visual (30%) or rhinologic (26%) problems, and facial pain and hypoesthesia (9%). 3 Sphenoid sinus carcinomas may cause neuro-ophthalmic symptoms such as diplopia, ptosis, proptosis, loss of vision, visual obscurations, and facial pain. Two large studies 1,3 reported isolated visual loss in three of 50 patients without giving any further detail.…”