Primary breast sarcoma: A retrospective study over 35 years from a single institution

Holm, Maibritt Provstgaard; Aggerholm‐Pedersen, Ninna; Mele, Marco; Jørgensen, Peter; Bærentzen, Steen; Safwat, Akmal

doi:10.3109/0284186x.2015.1093656

Cited by 24 publications

(24 citation statements)

References 22 publications

(84 reference statements)

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“…We performed a breast conservative surgery as suggested in few cases reported in literature. These studies showed no differences in outcome in patients with breast conservative surgery with microscopically negative margins compared with mastectomy (5,(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 94%

Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report

Testori¹,

Meroni²,

Voulaz³

et al. 2017

J. Thorac. Dis.

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Radiological and histological features of breast leiomyosarcoma can mimic a wide variety of other breast lesions, such as mesenchymal tumors, breast lymphomas, poorly differentiated carcinomas and metaplastic breast carcinomas. The authors present the case of a 62-year-old woman with a primary breast leiomyosarcoma with synchronous ipsilateral lung adenocarcinoma. The latter was an incidental finding during pre-surgical staging examinations. Clinicopathological, immunophenotypic and imaging features cancer are described. A brief review of the literature on imaging findings and management of breast leiomyosarcoma is presented. The authors discuss the differential diagnoses in breast imaging and of the extra-mammary incidental findings. Surgical resection remains the cornerstone of treatment, while radiation therapy and chemotherapy remain to be defined on a single-patient basis.

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Section: Discussionmentioning

confidence: 94%

Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report

Testori¹,

Meroni²,

Voulaz³

et al. 2017

J. Thorac. Dis.

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“…However, a history of rapid growth in a previous long standing indolent mass should raise the suspicion of a sarcoma. Diagnosis is made with the help of clinical findings, imaging and biopsy which allows a preoperative diagnosis to be made reliably while prognostic factors are size and grade with a trend towards better survival in those with superficial tumors 5,6 . We present a case of left breast sarcoma in University Malaya Medical Center (UMMC).…”

Section: Introductionmentioning

confidence: 99%

“…Sarcoma of the breast can be divided into two categories: de novo development (primary) or secondary with histologic subtypes which include malignant fibrous histiocytoma, liposarcoma, fibrosarcoma, clear cell sarcoma, neurogenic sarcoma, leiomyosarcoma and alveolar soft tissue sarcoma 6 . The most common subtype of primary breast sarcoma however is malignant phyllodes tumor and angiosarcoma 5 . Breast sarcoma usually presents as a painless breast mass that is large and mobile.…”

Section: Introductionmentioning

confidence: 99%

Primary Breast Sarcoma

Cs¹

2020

Bangladesh J Med Sci

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Breast sarcomas are an extremely rare and heterogeneous group of malignancies derived fromnon-epithelial elements of the gland constituting less than 1% of total breast malignanciesand less than 5% of all soft tissue sarcomas. It can be divided into two categories: de novodevelopment (primary) or secondary. These tumors are important as they have a high rate ofrecurrence and poor prognosis. In addition it is important to differentiate these tumors frombreast carcinoma as the treatment differs in these two entities. We present a case of primarybreast sarcoma in a 46 year old nulliparous Chinese woman. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.579-581

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“…Breast sarcoma is an extremely rare and heterogeneous disease, which includes a group of several subtypes of cancer [1, 2, 3, 4, 5, 6, 7]. They can appear as primary forms or secondary to radiation therapy or chronic lymphedema [3, 8].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the rarity and heterogeneity of breast sarcomas, there are no guidelines or published randomized trials that validate any particular treatment strategy. However, there is general agreement that surgical excision with adequate margins free of cancer cells should always be the first modality of treatment [1, 2, 3, 5, 12]. Radiation therapy and chemotherapy, although controversial, may be considered in patients with high risk of recurrence due to positive margin resection, tumors larger than 5 cm, or a high-grade sarcoma, since these lesions have a tendency to recur locally and can metastasize [1, 2, 3, 4].…”

Section: Introductionmentioning

confidence: 99%

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

Ramalho¹,

Campos²,

Rebelo³

et al. 2016

Case Rep Oncol

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Primary breast sarcoma, arising from connective tissue within the breast, is extremely rare, accounting for less than 1% of all primary breast malignancies and no more than 5% of all sarcomas. The rarity of this pathology limits most studies to case reports and small retrospective studies, which has led to a lack of consensus on the clinical management. We report a clinical case of a 52-year-old woman, perimenopausal, previously healthy, with regular breast surveillance, who presented with a large (>20 cm) and rapidly expanding hypervascularized tumor of the left breast developed over 10 days, with a very thin preulcerative skin over the last 4 days. There was no systemic dissemination. The patient was submitted to total mastectomy and excision of axillary adenopathy. The tumor was diagnosed histologically as malignant phyllodes tumor associated with areas of high-grade sarcoma. Due to rapid growth and aggressive histological characteristics, adjuvant chemotherapy and radiotherapy were performed. There is a lot of evidence that tumors larger than 5 cm are associated with a poor prognosis. Despite the poor prognosis associated with this aggressive entity, the patient had no recurrence during 5 years of follow-up. We review the relevant literature about primary breast sarcomas.

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Primary breast sarcoma: A retrospective study over 35 years from a single institution

Cited by 24 publications

References 22 publications

Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report

Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report

Primary Breast Sarcoma

A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report

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