Primary Breast Sarcoma: A rare pathology in women from the National Cancer Institute (INCan) of Mexico

INTRODUCTION: Primary breast sarcoma (PBS) was first described in 1887 as a rare heterogeneous neoplasm arising from the mesenchymal tissue of the mammary gland accounting for less than 5% of all body soft-tissue sarcomas and less than 0.1% of all malignant tumors of the breast. CASE PRESENTATION: A 31-year old lady presented with left breast mass which she felt four years before during which the mass increased in size from 1 to 6 cm in the largest diameter, diagnosed clinically as a benign fibroadenoma without any further cytological or histopathological confirmation. Histopathological examination of the excised breast mass reveals undifferentiated, primary stromal sarcoma of the breast (PSSB), which was followed by mastectomy three weeks later with reconstructive breast surgery with a total duration of follow-up of 3 years thereafter. This is the first case of PSSB reported in Jordan. DISCUSSION/CONCLUSION: PSSB is the generic term given to malignant breast tumors thought to arise from the specialized mesenchymal stroma of the breast but lacking an epithelial component with a phylloides pattern. PSSB is difficult to diagnose preoperatively due to its rarity and inadequate imaging methods to establish an exact diagnosis. The histology of the patient mass may be the leading factor for the management of these tumors. Even in very young patients, a progressively growing breast mass should alert the clinician to investigate for malignancy and verify the results by biopsy. Surgery with adequate resection margins represents the only potentially curative modality with prognostic significance. Adjuvant chemotherapy and radiotherapy are not very beneficial. The prognosis is dismal for patients with lymph node involvement and the size of the tumor has a lesser bearing on the outcome.

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Primary stromal sarcoma of breast: A case report and literature review

Al-Wiswasy

Al-Balas

Al-Saffar

et al. 2021

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Rare Sarcoma of Breast- Primary Osteosarcoma

Sugara

Ramesh

Ravikumar

2021

ijsr

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Extraskeletal osteosarcomas are malignant and arise from soft tissue that produce osteoid, without any continuity to skeletal bone. Primary osteosarcoma of breast is a rare clinical entity. Although reported previously, there are no available guidelines for their management. A 52- year old lady who presented with rapidly growing tumor in breast was managed surgically. We discuss the diagnostic challenges and role of adjuvant therapy in our report

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Primary Breast Sarcoma: A rare pathology in women from the National Cancer Institute (INCan) of Mexico

Cited by 2 publications

References 25 publications

Primary stromal sarcoma of breast: A case report and literature review

Primary stromal sarcoma of breast: A case report and literature review

Rare Sarcoma of Breast- Primary Osteosarcoma

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