Primary breast osteosarcoma: A case report and review of the literature

Omranipour, Ramesh; Ensani, Fereshteh; Hassanesfahani, Maryam

doi:10.1002/ccr3.5044

Cited by 3 publications

(1 citation statement)

References 43 publications

(104 reference statements)

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“…Notably, patients with ESOS originating in the 'Soft Tissue including Heart' category demonstrated a median survival of 33.0 months, markedly outperforming their counterparts originating from other sites (12.0 months for breast and 19.9 months for lung, respectively). This concurs with previously reported ndings [4,8,23,24,25]. Super cial ESOS masses, being more readily detectable, facilitate early-stage diagnosis and subsequent intervention.…”

Section: Discussionsupporting

confidence: 93%

Epidemiological and clinicopathologic characteristics, and prognostic factors of patients with Extra-skeletal Osteosarcoma

Liu,

Gao,

et al. 2024

Preprint

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The aim of this study was to investigate the epidemiological characteristics and prognostic factors of Extra-skeletal Osteosarcoma (ESOS) and to establish and validate a prognostic model. The baseline information and survival outcome of patients was illustrated according to different primary tumor sites. The independent prognostic factors for ESOS were analyzed using univariate and multivariate Cox regression analysis. A nomogram was constructed using these prognostic factors to predict the prognostic survival of patients. Kaplan-Meier method was performed to estimate survival and both log-rank test and Wilcoxon-Breslow-Gehan test were used to compare the survival. A total of 4567 patients with osteosarcoma who met the inclusion criteria were enrolled, including 4317 patients with osteosarcoma of bone and joint origin and 250 patients with ESOS. The 1-, 3-, and 5-year tumor-specific survival rates for ESOS were lower than those for skeletal osteosarcoma. Multivariate Cox analysis showed that older age at diagnosis, distant staging, and presence of bone metastases were independent risk factors affecting patient prognosis, and surgery of the primary site was an independent factor suggesting a better survival outcome. A nomogram was created based on these factors to predict OS at 1, 3 and 5 years in patients with ESOS. An internally validated nomogram consistency index showed satisfactory results between predictions. Primary focus surgery is an important factor in improving survival outcomes in patients with ESOS. The nomogram for predicting the prognostic of patients with ESOS was proved to be favorable accuracy and reliability. Such prognostic nomogram may assist clinicians optimize clinical treatment.

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Section: Discussionsupporting

confidence: 93%

Epidemiological and clinicopathologic characteristics, and prognostic factors of patients with Extra-skeletal Osteosarcoma

Liu,

Gao,

et al. 2024

Preprint

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Extra-skeletal osteosarcoma: a review

et al. 2022

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Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

Xue

Shi

2022

Front. Oncol.

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BackgroundPrimary osteosarcoma of the breast (POB) is an extremely aggressive and heterogeneous neoplasm that originates from nonepithelial elements of the mammary gland and accounts for fewer than 1% of breast cancers and fewer than 5% of all sarcomas.Case PresentationAn 83-year-old Chinese woman went to our hospital because of a palpable mass she had had for 8 months in the left breast accompanied by persistent dull pain for 10 days. This mass was initially misdiagnosed as a degenerating fibroadenoma and was graded as probably benign (BI-RADS category 3) by ultrasonography (US) and computed tomography (CT) plain scan and contrast enhancement of chest. Eight months later, it was presumed to be highly malignant and graded as BI-RADS category 4C because of its rapid growth and more calcifications by US and CT. 99mTc-MDP whole-body bone imaging showed that there was a mass-like abnormal radioactive concentration of Tc-99m outside the bone of the left chest. The lumpectomy of the left breast was indicated, and the pathological findings were POB. She succumbed to respiratory failure caused by multiple lung metastases 4 months after the operation.ConclusionPOB is rare, and US and CT cannot reliably distinguish the causes of calcified breast masses between benign and malignant tumors. It can be diagnosed by pathology when metaplastic carcinoma, malignant phyllodes tumor, or carcinosarcoma containing osteoid and bone is excluded. This case could help clinicians to improve the prognosis and treatment of this disease.

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Primary breast osteosarcoma: A case report and review of the literature

Cited by 3 publications

References 43 publications

Epidemiological and clinicopathologic characteristics, and prognostic factors of patients with Extra-skeletal Osteosarcoma

Epidemiological and clinicopathologic characteristics, and prognostic factors of patients with Extra-skeletal Osteosarcoma

Extra-skeletal osteosarcoma: a review

Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

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