Primary Breast Lymphoma: A Case Series and Review

Abstract

The primary breast lymphoma (PBL) is a rare manifestation of extranodal non-Hodgkin's lymphoma. The clinical features are indistinguishable to that of breast carcinoma. They usually do not have characteristic clinical and imaging findings. The preoperative diagnosis of PBL is difficult and the diagnosis is based on biopsy and immunohistochemical staining. Diffuse large B-cell lymphoma is the most common histological diagnosis. We retrospectively analyzed four cases of PBL who attended at our center, between 1997 and 2019 and discussed to determine the common clinical features and therapy. These cases were originally treated by chemotherapy, that is, rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP/CHOP) or combined chemotherapy and radiotherapy and had recurrence in the central nervous system (CNS). Due to the high incidence of CNS involvement in these patients, many authors strongly believe that patients with aggressive forms of PBL should receive CNS prophylaxis, even in the early stages, as this may improve the outcome and significantly reduce the risk of a CNS relapse.

Male’s Primary Breast Lymphoma: Rare Entity of Breast Malignancy, Wad Madani Teaching Hospital, Gezira State, Sudan, August 2023

“…Our case present with breast lump in the left upper outer quadrant associated with pain; this was similar to other case reports [3][4][5]. The presentation of our case was mimicking breast carcinoma which was similar to many worldwide case reports [1,2,4,5,9,11]. The histological type of our case was diffuse large B cell lymphoma like many studies [3,6,7,9].…”

“…This was an extremely rare case of male's primary breast lymphoma which was inconsistent with many international studies [3,4,7]. Our case present with breast lump in the left upper outer quadrant associated with pain; this was similar to other case reports [3][4][5].…”

“…Primary breast lymphoma (PBL); is defined as a malignant lymphoma primarily involving the breast in the absence of previously detected lymphoma localizations. SBL is defined by the presence of secondary involvement of breast tissue by a concurrent or previous systemic lymphoma and is more common than PBLs [2][3][4][5][6][7]. PBL is characterized by primary degeneration of the breast lymphoid tissue with or without damage to the lymph nodes in the drainage area.…”

“…Primary breast lymphoma has no clinical and radiological features and present similar to breast carcinoma. It can present with painless lump usually in the upper outer quadrant, and may be associated with local pain and inflammation and sometimes may present with palpable lymph nodes [2][3][4][5][6][7][8][9][10][11][12][13]15].…”

Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital

“…[11] (Table 3) NHL breast patient was a beggar who was accompanied by a blind fellow who used to sell newspapers and magazines in the running trains. [12] (Table 4) One cancer breast patient presented with synchronous bilateral disease with distant metastasis. One breast cancer patient's mother and aunt were also treated for breast cancer in the past (Table 4).…”