Primary breast leiomyosarcoma: case report and literature review

Abstract

<b>PURPOSE</b>: Leiomyosarcoma of the breast is extremely rare. To date, the factors that are predictive of patient prognosis have not been identified. To clarify the nature of leiomyosarcoma of the breast, and also to establish the proper treatment strategy, we report this case We report this case while discussing The Clinical presentation, diagnosis, therapy and pathologic feature. <b>INTRODUCION</b>: Sarcomas comprise less than 1% of all primary breast neoplasms and only a minority of these are leiomyosarcomas. There were only 35 cases being reported in English literature. The mainstay of treatment is surgical excision with clear margins and longterm followup is essential. Its prognosis is better compared to other breast sarcoma. <b>CASE PRESENTATION</b>: We report a case of primary leiomyosarcoma of the breast occurring in young female patient which was successfully treated by surgery and radiotherapy. <b>CONCLUSION</b>: According to literature data, primary leiomyosarcoma is characterized by a better prognosis compared with other breast sarcomas, To date, the factors that are predictive of patient prognosis have not been identified. .The rarity and diagnostic difficulty imposed a multidisciplinary approach

Primary breast leiomyosarcoma with metastases to the lung in a young adult: Case report and literature review

“…Although sarcomas can occur anywhere in the body, less than 1% of all breast neoplasms consist of sarcomas [2] , [3] , [4] , [5] . LMS is a rare subtype of breast sarcoma.…”

“…Definitive diagnosis relies on the results or core needle [6] , or excisional biopsy. Histologically, potential origin of the malignant cells include; blood vessel smooth musculature, smooth muscle of the nipple areolar complex, or malignant transformation from benign neoplasms, such as leiomyoma or other spindle cell tumors [2] , [7] .…”

“…Diagnostic histologic characteristics consist of interlacing spindle cell bundles [2] , [4] with further grading via degree of atypia, mitotic activity, cellularity, and nuclear pleomorphism [4] .…”

“…Primary breast sarcoma is an uncommon neoplasm with incidence of 0.5–1%. Breast leiomyosarcoma (LMS) is a rare subtype of breast sarcoma, constituting 5–10% of breast sarcomas [2] , making it an extraordinarily rare malignancy. There are less than 70 documented cases in the literature, the majority of which are case reports, with the earliest appearing in 1968.…”

The quintessence of breast leiomyosarcoma

“…Leiomyosarcomas belong to a less common subgroup (5% to 10%) of sarcomas of the breast. 1 Although they represent only a small fraction of all breast pathology, this heterogeneous group of lesions has a large scope ranging from reactive and benign proliferations to aggressive malignant neoplasms. 2 Spindle cell lesions have an increased number of spindled and pleomorphic cells with intermixed fascicles of relatively regular cells with fusiform nuclei.…”