Primary Breast Cancer

Demirkan, Hatice Mirac Binnaz; Durak, Hatice

doi:10.1016/b978-012374212-4.50047-x

Cited by 1 publication

(1 citation statement)

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“…Radionuclide works by detecting areas of increased or decreased bone turnover activity, and the present work provides the potential for detecting bone metastases (49). A commonly used radionuclide for bone scintigraphy is 99mTc-MDP via SPECT/CT scan, which was generally used to localise bone metastases or any abnormal activity within the bone, such as lesions and hypercalcemia (50). Hypercalcemia is usually a result of high calcium levels caused by the secretion of cancer cells' growth factors that stimulate calcium production within the bone, which in turn alters the calcium homeostasis activity in the bone (51).…”

Section: Discussionmentioning

confidence: 97%

Vitamin E Action on Bone Signaling Pathways, Rankl/Rank/Opg in a Rat Model of Breast Cancer-Induced Bone Pain

Baharuddin,

Syifaa Nasir,

Mansor

et al. 2023

JUMMEC

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Cancer-induced bone pain is currently facing inadequate pain management due to unwanted side effects and relative ineffectiveness. The search for alternative therapy to alleviate pain and target a few mechanism pathways might improve survival in metastatic patients. Vitamin E which has been promoted as anti-inflammatory, anti-cancer, and anti-metastatic were chosen in this study to potentiate its capability in a cancer-induced bone pain rat model. Rats were randomly grouped into five groups, and a breast cancer cell line was induced into the left femur of four groups: Negative Control (NC), Alpha Tocopherol (ATF), Tocotrienol Rich Fraction (TRF) and Zoledronic Acid (ZA), whereas Sham group as healthy subjects induced with supplementary media. Pain assessment tests were carried out at four days intervals. The animals were sacrificed after 21 days following SPECT/CT imaging. Bone specimens were analyzed for ELISA and gene expression studies. The results showed that the animal model was successfully validated via the presence of abnormal uptake of the skeletal system. Pain assessment tests demonstrated that vitamin E, specifically TRF significantly alleviate pain compared to the NC group. Biomarker activity illustrated that the TRF supplement group was able to regulate the bone turnover activity comparable to the ZA treatment group. Gene expression studies signify the role of TRF supplement comparable to the ZA group in the ability to regulate osteoclastogenesis, osteoclast activation, and regulating the secretion of metastatic cancer cytokine. This finding addressed the beneficial potency of TRF compared to ATF as a therapeutic option in the management of cancer-induced bone pain.

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Section: Discussionmentioning

confidence: 97%