Primary Breast Cancer After Prophylactic Mastectomy

Ziegler, L. D.; Kroll, Stephen S.

doi:10.1097/00000421-199110000-00018

Cited by 65 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At a median follow-up of 14 years, the incidence of new breast cancers was only 1.1%, representing a 91% reduction in risk when compared with female siblings who had not undergone prophylactic mastectomy. Similarly, Ziegler & Kroll (1991), re-analyzing data originally reported by Pennisi & Capozzi (1989), found an incidence of 1.2% in 510 high-risk patients who had undergone prophylactic mastectomy.…”

Section: Prophylactic Mastectomymentioning

confidence: 87%

New approaches to surgery for breast cancer.

Singletary¹

2001

Endocrine-Related Cancer

View full text Add to dashboard Cite

The surgical management of breast cancer is rapidly evolving towards less invasive procedures. Alternative biopsy techniques, including fine-needle aspiration and core needle biopsy, are replacing excisional biopsy as the treatment standard. Breast conservation therapy is now widely used in place of mastectomy, both for small tumors and for larger tumors that have been downstaged through induction chemotherapy. Less invasive procedures for axillary treatment such as lymphatic mapping and sentinel lymph-node biopsy are being explored in an effort to avoid the morbidity associated with axillary lymph-node dissection. For women who still prefer or need to receive a mastectomy, immediate breast reconstruction with autologous tissue provides an excellent cosmetic outcome that is oncologically sound. This is especially appealing to high-risk women who opt to have a prophylactic mastectomy. High-risk women are also being offered the option of receiving chemopreventive treatment that may reduce their lifetime risk of cancer by almost 50%. These new, less invasive approaches require the close cooperation of a team of physicians, including surgeons, pathologists, radiologists, and medical and radiation oncologists.

show abstract

Section: Prophylactic Mastectomymentioning

confidence: 87%

New approaches to surgery for breast cancer.

Singletary¹

2001

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…The change in the proportion of women undergoing total as opposed to subcutaneous mastectomy may be due to the published reports of failure following prophylactic mastectomies. 1,[17][18][19] The majority of failures occurred in women who had a subcutaneous mastectomy.…”

Section: Discussionmentioning

confidence: 99%

“…All residents are covered under the provincial health plan, which covers the majority of diagnostic and treatment services, including prophylactic mastectomy. 19), and bilateral subcutaneous mastectomy with (97.23) or without (97.24) implantation of prostheses. Hospitals that were identified as having performed at least one prophylactic bilateral mastectomy in the designated time period were then contacted and ethics approval was obtained from each institution.…”

Section: Identification Of Subjectsmentioning

confidence: 99%

Prophylactic bilateral mastectomy

Metcalfe¹,

Goel²,

Lickley³

et al. 2002

Cancer

View full text Add to dashboard Cite

BACKGROUND.Many women who are at an elevated risk of developing breast carcinoma choose prophylactic mastectomy to decrease their risk. We conducted a population-based study to review the indications for, and patterns of practice of prophylactic mastectomy in Ontario, Canada, since 1991. METHODS.A medical chart review was conducted at 33 hospitals that were identified as having conducted at least one prophylactic mastectomy. All bilateral mastectomy patients with no diagnosis of invasive or in situ breast carcinoma were eligible. RESULTS.The number of prophylactic bilateral mastectomies performed varied from 6 to 19. The mean age of women undergoing prophylactic mastectomy was 43.5 years. Eighty percent of the women had prophylactic mastectomy performed because of a family history of breast carcinoma (89 of 99) or because of a known BRCA1 or BRCA2 mutation (10 of 99). Twenty percent of the women had no family history, but had the surgery for other benign breast conditions. Women with a family history of breast carcinoma were much more likely to have a total mastectomy (89%) than a subcutaneous mastectomy (11%). Sixty percent of the women had reconstructive surgery following mastectomy.

show abstract

“…Nach Informationen der Deutschen Krebshilfe ließen sich in Deutschland fünf Prozent der Frauen nach einem positiven Gentest und anschließender gynäkologischer Beratung prophylaktisch den Eierstock entfernen oder die Brust amputieren (Wagenmann 2003, 33). 6 Aber selbst bei diesem äußerst schwerwiegenden Eingriff ist nicht ganz sicher, dass die Krebsentstehung verhindert werden kann, da es in Einzelfällen dennoch zu Tumorbildungen kommt (Ziegler/Kroll 1991 (Freedman 1998;Hallowell 1999;Hallowell 2000). Sie unterzogen sich weiteren medizinischen Interventionen und nahmen regelmäßig an Kontrolluntersuchungen teil.…”

Section: Veranlagung Als Verantwortung? Das Beispiel Der Brustkrebsgeneunclassified

Die Gene der Frau – Humangenetik als Arena der Geschlechterpolitik

Lemke¹

2004

Feministische Studien

View full text Add to dashboard Cite

Primary Breast Cancer After Prophylactic Mastectomy

Cited by 65 publications

References 0 publications

New approaches to surgery for breast cancer.

New approaches to surgery for breast cancer.

Prophylactic bilateral mastectomy

Die Gene der Frau – Humangenetik als Arena der Geschlechterpolitik

Contact Info

Product

Resources

About