Primary Bone Lymphoma

Bhagavathi, Sharathkumar; Fu, Kai

doi:10.5858/133.11.1868

Cited by 37 publications

(23 citation statements)

References 19 publications

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“…Meanwhile, Pfreundschuh et al [ 19 ] suggested that rituximab in combination with CHOP-like chemotherapy regimens improves the long-term prognosis of young patients with PB-DLBCL. Bhagavathi and Fu's study [ 20 ] found that the addition of rituximab increased three-year progression-free survival (PFS) from 52% to 88%. Radiotherapy used the usual doses for non-Hodgkin's lymphoma (35–45 Gy in 1.8–2 Gy fractions) [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Nomogram-Based Prediction of Overall and Cancer-Specific Survival in Patients with Primary Bone Diffuse Large B-Cell Lymphoma: A Population-Based Study

Yang

Zhao

2022

Evidence-Based Complementary and Alternative Medicine

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Background. Primary bone diffuse large B-cell lymphoma (PD-DLBCL) accounts for more than 80% of primary bone lymphoma. We created two nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in patients with PD-DLBCL for this rare disease. Methods. In total, 891 patients diagnosed with PB-DLBCL between 2007 and 2016 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox analyses were performed to explore independent prognostic factors and create nomograms for OS and CSS. The area under the curve (AUC), the calibration curve, decision curve analysis (DCA), and Kaplan–Meier (K-M) curve analysis were used to evaluate the nomograms. Results. Four variables were identified as independent prognostic factors for OS, and three variables were identified as independent prognostic factors for CSS. The receiver operating characteristic (ROC) curves demonstrated the strong discriminatory power of the nomograms. The calibration and DCA curves showed that the nomograms had a satisfactory ability to predict OS and CSS. The K-M curves showed that age, gender, primary site, chemotherapy, and tumor stage affected patient survival. Conclusions. In patients with PD-DLBCL, age, race, primary site, and chemotherapy affected OS, while age, race, and chemotherapy affected CSS. The two nomograms created based on the aforementioned variables provided more accurate individual survival predictions for PD-DLBCL patients and can help physicians make appropriate clinical decisions.

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Section: Discussionmentioning

confidence: 99%

Nomogram-Based Prediction of Overall and Cancer-Specific Survival in Patients with Primary Bone Diffuse Large B-Cell Lymphoma: A Population-Based Study

Yang

Zhao

2022

Evidence-Based Complementary and Alternative Medicine

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“…The male to female ratio was 1.5 / 1. Most primary bone lymphomas are DLBCL (26). All of the cases in our series were DLBCL.…”

Section: Discussionmentioning

confidence: 54%

“…According to Bhagavathi's review, primary bone lymphoma is a rare entity; it constitutes 4-5% of ENLs and 3% of all bone malignancies (26). The 27.8% of musculoskeletal lymphomas in our series primarily occurred in the bone.…”

Section: Discussionmentioning

confidence: 61%

Clinicopathological Features of Extranodal Lymphomas

Coşkun

Nazlioglu

Büyükuysal

2021

Konuralp Tıp Dergisi

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Objective: In this study, we aimed to evaluate the localization and histopathological diagnosis, and clinicopathologic characteristics of primary extranodal lymphomas. Methods: The pathology reports between 2001 and 2015 in the archives of Uludag University Faculty of Medicine Pathology Department were reviewed and all cases with an extranodal lymphoma diagnosis were analyzed. The information about the diagnosis, tumor localization, symptoms at presentation, presence of B symptoms, lymphocytosis and anemia, chronic infection and chronic disease and concomitant secondary malignancy, tumor diameter, the involvement of another extranodal organ, lymph node, bone marrow, spleen, liver, stage of the disease, serum B2 microglobulin, LDH, albumin levels, sedimentation rate were documented. The localization, histopathological types, age groups, male/female ratios in cases of primary extranodal lymphoma were evaluated. Results: Total sum of 1743 patients were diagnosed with lymphoma. 480 (%27,53) of these cases were extranodal lymphomas. The most commonly encountered locations of extranodal lymphomas were the skin and the gastrointestinal system. There were 226 primary extranodal skin, 90 gastrointestinal system, 44 central nervous system, 8 genitourinary system, 50 head and neck, 18 musculoskeletal system and soft tissue, 9 mediastinum, 3 bronchus, 10 orbital, 2 liver, 6 pancreas, 4 omentum, 8 endocrine system, and 2 breast located cases. 237 of the primary extranodal lymphomas from our work were mature T/NK celled neoplasias. There were 250 patients with mature B cell lymphoma, 5 cases of Hodgkin lymphoma, and 5 cases of precursor lymphoid neoplasia. Conclusions: The data from our series were coherent with the literature. Due to the small number of cases with some localization and some histopathological diagnosis, no significant results could be reached about these entities.

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“…Histologically, PBL is characterised by a diffuse cellular population infiltrating bony trabeculae and medullary fat [6]. Immunohistochemical analysis confirms diffuse positivity for CD20 [2].…”

Section: Discussionmentioning

confidence: 87%