Primary Biliary Cirrhosis is not an Additional Risk Factor for Bone Loss in Women Receiving Regular Calcium and Vitamin D Supplementation

Benetti, Alberto; Crosignani, Andrea; Varenna, M.; Giussani, C.; Allocca, Mariangela; Zuin, Massimo; Podda, Mauro; Battezzati, Pier Maria

doi:10.1097/01.mcg.0000248017.31386.39

Cited by 29 publications

(17 citation statements)

References 25 publications

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“…However, the relative increase of any fracture, hip fracture and ulna/radius fracture was as high as two‐fold for the PBC cohort . This observation is compelling, because of the suggestion of osteoporosis not being a complication of PBC, but just an expected disorder among postmenopausal middle‐aged women . Osteoporosis occurs frequently among patients with primary sclerosing cholangitis.…”

Section: Prevalence Of Osteoporosis and Fracturesmentioning

confidence: 93%

“…18 This observation is compelling, because of the suggestion of osteoporosis not being a complication of PBC, but just an expected disorder among postmenopausal middle-aged women. 7,19,20 Osteoporosis occurs frequently among patients with primary sclerosing cholangitis. In these patients old age, low body mass index, and long duration of inflammatory bowel disease correlated with low bone mass.…”

Section: Pre Valen Ce Of Os Teop Oros Is and Fr Ac Tu Re Smentioning

confidence: 99%

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Osteoporosis in chronic liver disease

Guañabens

Parés

2018

Liver International

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Osteoporosis is a frequent complication in patients with chronic liver disease, especially in end-stages and in chronic cholestasis, in addition to non-alcoholic fatty liver disease, haemochromatosis and alcoholism. Mechanisms underlying osteoporosis are poorly understood, but osteoporosis mainly results from low bone formation. In this setting, sclerostin, a key regulator of the Wnt/β-catenin signalling pathway which regulates bone formation, in addition to the effects of the retained substances of cholestasis such as bilirubin and bile acids on osteoblastic cells, may influence the decreased bone formation in chronic cholestasis. Similarly, the damaging effects of iron and alcohol on osteoblastic cells may partially explain bone disease in haemochromatosis and alcoholism. A role for proinflammatory cytokines has been proposed in different conditions. Increased bone resorption may occur in cholestatic women with advanced disease. Low vitamin D, poor nutrition and hypogonadism, may be contributing factors to the full picture of bone disorders in chronic liver disease.

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Section: Prevalence Of Osteoporosis and Fracturesmentioning

confidence: 93%

Section: Pre Valen Ce Of Os Teop Oros Is and Fr Ac Tu Re Smentioning

confidence: 99%

Osteoporosis in chronic liver disease

Guañabens

Parés

2018

Liver International

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“…All these observations are of interest, because as other studies suggest, osteoporosis is not a specific complication of PBC, its frequency being the one expected in a population of middle-aged postmenopausal women [19].…”

Section: Prevalence Of Osteoporosis and Fractures In Chronic Liver DImentioning

confidence: 92%

Osteodystrophy in chronic liver diseases

et al. 2012

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Osteoporosis and osteomalacia are, to date, among the most common metabolic diseases in the world. Lately, an association between metabolic bone diseases and chronic liver disease has been increasingly reported, inducing many authors to create a new nosographic entity known as 'hepatic osteodystrophy. ' The importance of such a condition is further increased by the morbidity of these two diseases, which greatly reduce the quality of life because of frequent fractures, especially vertebral and femoral neck ones. For this reason, early identification of high-risk patients should be routinely performed by measuring bone mass density. The explanation for the association between bone diseases and chronic liver disease is still uncertain, and involves many factors: from hypogonadism to use of corticosteroid drugs, from genetic factors to interferon therapy. To date, few studies have been conducted, and all with a small number of patients to establish definitive conclusions about the possible treatment, but some evidence is beginning to emerge about the safety and efficacy of bisphosphonates.

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“…It is not clear whether this is ultimately different when compared to sex-and agematched healthy individuals [14] . Current treatment of this condition is similar to other cases of osteopenia and osteoporosis and includes oral calcium supplementation and vitamin D replacement.…”

Section: Clinical Featuresmentioning

confidence: 96%

Late-Onset Autoimmunity: The Paradigm of Primary Biliary Cirrhosis – A Mini-Review

et al. 2008

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The incidence of autoimmune diseases appears to be increasing in virtually every population. This is well illustrated by primary biliary cirrhosis, a disease characterized by an immune response to small bile ducts and an incidence increasing with age. The etiology of primary biliary cirrhosis remains enigmatic, although there is clearly an interplay of genetics and environment with a possible role for immunosenescence. The increasing usage of serologic tests for the hallmark of primary biliary cirrhosis, the antimitochondrial antibody, has dramatically changed the spectrum of disease presentation and natural history. In the past, data were predominantly based on the greater prevalence of advanced cases, whereas now most patients are detected earlier through the use of multi-phasic chemistry panels. In this review, we will place the epidemiology of primary biliary cirrhosis in the context of its clinical features and treatment as well as emphasize the future directions to further understand the immunobiology of this disease.

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Primary Biliary Cirrhosis is not an Additional Risk Factor for Bone Loss in Women Receiving Regular Calcium and Vitamin D Supplementation

Abstract: Among patients with PBC, the prevalence of osteoporosis and the yearly rate of BMD loss are similar to those observed in the general population, and are not associated with the severity of liver disease.

Cited by 29 publications

References 25 publications

Osteoporosis in chronic liver disease

Osteoporosis in chronic liver disease

Osteodystrophy in chronic liver diseases

Late-Onset Autoimmunity: The Paradigm of Primary Biliary Cirrhosis – A Mini-Review

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