Primary biliary cirrhosis in India

Samanta, Arijit; Bhagwat, A G; Mukherjee, M.; Gupta, Nidhi; Sehgal, Sona; Datta, D. V.

doi:10.1136/gut.14.6.448

Cited by 9 publications

(7 citation statements)

References 5 publications

(9 reference statements)

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“…Since the first report of PBC from India in 1973, 26 few series have been reported. In a study by Manga et al .…”

Section: Discussionmentioning

confidence: 99%

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Spectrum of autoimmune liver diseases in western India

Amarapurkar

Patel

2007

J of Gastro and Hepatol

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“…Since the first report of PBC from India in 1973, 26 few series have been reported. In a study by Manga et al .…”

Section: Discussionmentioning

confidence: 99%

“…Since the first report of PBC from India in 1973, 26 few series have been reported. In a study by Manga et al 13 patients were reported over 10 years (54% had positive ANA/ASMA, suggestive of probable overlap syndrome) 19 and in a study by Puri et al five patients were reported over 5 years.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of autoimmune liver diseases in western India

Amarapurkar

Patel

2007

J of Gastro and Hepatol

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“…For example, southern Africa is endemic for tuberculosis, but PBC is relatively rare in those regions [128, 129]. The same could be said for India and China, which have relatively high rates of tuberculosis but low rates of PBC [130–132]. Also, epidemiological studies assessing susceptibility to PBC would be expected to identify tuberculosis as a risk factor.…”

Section: Granulomas In Pbcmentioning

confidence: 99%

Tuberculosis Is Not a Risk Factor for Primary Biliary Cirrhosis: A Review of the Literature

Smyk

Bogdanos

Pares

et al. 2012

Tuberculosis Research and Treatment

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Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease characterised serologically by cholestasis and the presence of high-titre antimitochondrial antibodies, and histologically by chronic nonsuppurative cholangitis and granulomata. As PBC is a granulomatous disease and Mycobacterium tuberculosis is the most frequent cause of granulomata, a causal relation between tuberculosis and PBC has been suggested. Attempts to find serological evidence of PBC-specific autoantibodies such as AMA have been made and, conversely, granulomatous livers from patients with PBC have been investigated for molecular evidence of Mycobacterium tuberculosis. This paper discusses in detail the reported data in support or against an association between Mycobacterium tuberculosis infection and PBC. We discuss the immunological and microbiological data exploring the association of PBC with exposure to Mycobacterium tuberculosis. We also discuss the findings of large epidemiologic studies investigating the association of PBC with preexistent or concomitant disorders and the relevance of these findings with tuberculosis. Genome-wide association studies in patients with tuberculosis as well as in patients with PBC provide conclusive hints regarding the assumed association between exposure to this mycobacterium and the induction of PBC. Analysis of these data suggest that Mycobacterium tuberculosis is an unlikely infectious trigger of PBC.

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“…Autoimmune diseases of liver are defined relatively simply by clinical, biochemical, radiologic and histopathological criteria into those characterized predominantly by hepatitis (AIH) or by cholestasis (PBC) [ 1 ]. PBC & AIH are the two main immune mediated liver diseases that lie at opposite ends of the spectrum of autoimmune liver diseases and differ remarkably with respect to pathological findings and therapeutic intervention.…”

Section: Introductionmentioning

confidence: 99%

Incipient primary biliary cirrhosis/autoimmune hepatitis overlap or hepatitic form of primary biliary cirrhosis: a case report

et al. 2009

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A 42 year old asymptomatic female detected as incipient Primary Biliary Cirrhosis/Autoimmune Hepatitis overlap during routine checkup. The biochemical profile showed evolution from a mildly deranged liver function test in 2004 along with increased erythrocyte sedimentation rate to a 4 times elevation of alkaline phosphatase in 2006 with mildly deranged alanine transaminase. Autoimmune markers demonstrable were Anti mitochondrial antibody M2 and sp100. Histopathology showed dual features, dominant findings were of autoimmune heptatitis. Features consistent with Primary Biliary Cirrhosis were minimal with an occasional portal tract showing paucity of bile ducts and occasional bile duct proliferation. Human leucocyte antigen DR/DQ genotype was as follows: DRB1*03, DRB1*07, DQB1*02, DQB1*04.

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Primary biliary cirrhosis in India

Cited by 9 publications

References 5 publications

Spectrum of autoimmune liver diseases in western India

Spectrum of autoimmune liver diseases in western India

Tuberculosis Is Not a Risk Factor for Primary Biliary Cirrhosis: A Review of the Literature

Incipient primary biliary cirrhosis/autoimmune hepatitis overlap or hepatitic form of primary biliary cirrhosis: a case report

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