Primary biliary cirrhosis/autoimmune hepatitis overlap syndrome developing in a patient with systemic lupus erythematosus: a case report and review of the literature

González, LA; Orrego, Mauricio; Ramírez, LA; Vásquez, Gloria

doi:10.1177/0961203310378673

Cited by 15 publications

(15 citation statements)

References 15 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is commonly termed ''overlap syndrome'' [24][25][26][27][28][29][30]. Histological findings such as ductopenia or cholangitis may support a concurrent diagnosis of one of these conditions.…”

Section: Diagnosis and Clinical Presentationmentioning

confidence: 95%

Autoimmune hepatitis: a review

Gossard

Lindor

2012

J Gastroenterol

View full text Add to dashboard Cite

Autoimmune hepatitis (AIH) is an inflammatory liver disease that predominantly affects females. The disease is characterized histologically by interface hepatitis, biochemically by increased aspartate and alanine aminotransferase levels, and serologically by the presence of autoantibodies and elevated levels of immunoglobulin G. AIH affects both adults and children, and is particularly aggressive in the latter group. It is a relatively rare but devastating disease, which progresses rapidly unless immunosuppressive treatment is started promptly. Treatment is often successful at inducing remission of disease, and this can lead to a normal life expectancy. However, progression to cirrhosis can and does occur in some. For those with advanced-stage disease and complications, consideration of liver transplantation is appropriate.

show abstract

Section: Diagnosis and Clinical Presentationmentioning

confidence: 95%

Autoimmune hepatitis: a review

Gossard

Lindor

2012

J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…1,5 Based on our recent research, we would highlight lupus hepatitis (LH) as a common cause of liver function test abnormalities in SLE, being recognized in 3-8% of patients. 6,7 Usually, LH occurs subclinically, with anti-ribosomal-P antibodies seropositivity 8 and with fluctuation of alanine transaminase (ALT) levels according to change in SLE activity.…”

Section: Sirmentioning

confidence: 99%

Two different clinical subsets of lupus hepatitis exist. Mimicking primary autoimmune liver diseases or part of their spectrum?

Piga

Vacca

Porru

et al. 2011

Lupus

View full text Add to dashboard Cite

“…However, the co-existence of PBC and SLE is the subject of few reports in the literature, mostly based upon single case reports [42,43] . A large-scale study reported that, among 1032 PBC patients, 27 (0.03%) had also SLE [44] .…”

Section: Sle-pbc Overlap Syndromementioning

confidence: 99%

Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis

Bessone

Poles

Roma

2014

WJH

106

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows: (1) immunological comorbilities (overlap syndromes); (2) non-immunological comorbilities associated to SLE; and (3) a putative liver damage induced by SLE itself, referred to as "lupus hepatitis". In the first group, liver injury can be ascribed to overlapping hepatopathies triggered by autoimmune mechanisms other than SLE occurring with higher incidence in the context of lupus (e.g. , autoimmune hepatitis, primary biliary cirrhosis). The second group includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoagulation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug-induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The pathological mechanisms underlying each of these liver disorders are also reviewed. Despite the high heterogeneity in the literature regarding the prevalence of SLE-associated liver diseases and, in most cases, lack of histopathological evidence or clinical studies large enough to support their existence, it is becoming increasingly apparent that liver is an important target of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drugs. Diagnosing liver disease in SLE patients is always challenging, and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding of pathogenesis and to build an appropriate work-up for diagnosis.

show abstract

Primary biliary cirrhosis/autoimmune hepatitis overlap syndrome developing in a patient with systemic lupus erythematosus: a case report and review of the literature

Cited by 15 publications

References 15 publications

Autoimmune hepatitis: a review

Autoimmune hepatitis: a review

Two different clinical subsets of lupus hepatitis exist. Mimicking primary autoimmune liver diseases or part of their spectrum?

Challenge of liver disease in systemic lupus erythematosus: Clues for diagnosis and hints for pathogenesis

Contact Info

Product

Resources

About