Primary biliary cirrhosis and osteoporosis: a bidirectional two-sample Mendelian randomization study
Diqian Zhao,
Guobi Li,
Wenzhe Bai
et al.
Abstract:BackgroundObservational studies have identified a heightened risk of osteoporosis and fractures in patients with primary biliary cholangitis (PBC). However, conclusive evidence establishing a causal relationship between the two, and a clear mechanism explaining this association, remains elusive.MethodsWe conducted a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between PBC and osteoporosis. This analysis utilized five MR methods: inverse-variance weighted… Show more
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