Primary biliary cirrhosis and coronary atherosclerosis: Protective antioxidant effect of bilirubin

Dudnik, L. B.; Azyzova, O. A.; Solovyova, N. P.; Savchenkova, A. P.; Pokrovskaya, M. A.

doi:10.1007/s10517-008-0019-4

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…Confirming several other reports, our study shows a lower risk for myocardial ischemia in patients with cholestatic liver disease versus NASH/cryptogenic liver disease . These results suggest the need for an individualized approach to cardiac assessment and risk stratification of liver transplant candidates with NASH.…”

Section: Discussionsupporting

confidence: 90%

Adverse cardiac events after orthotopic liver transplantation: A cross‐sectional study in 389 consecutive patients

et al. 2014

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Current American College of Cardiology/American Heart Association guidelines caution that preoperative noninvasive cardiac tests may have poor predictive value for detecting coronary artery disease in liver transplant candidates. The purpose of our study was to evaluate the role of clinical predictor variables for early and late cardiac morbidity and mortality and the predictive values of noninvasive cardiac tests for perioperative cardiac events in a high-risk liver transplant population. In all, 389 adult recipients were retrospectively analyzed for a median follow-up time of 3.4 years (range 5 2.3-4.4 years). Overall survival was 83%. During the first year after transplantation, cardiovascular morbidity and mortality rates were 15.2% and 2.8%. In patients who survived the first year, cardiovascular morbidity and mortality rates were 3.9% and 2%, with cardiovascular etiology as the third leading cause of death. Dobutamine stress echocardiography (DSE) and single-photon emission computed tomography had respective sensitivities of 9% and 57%, specificities of 98% and 75%, positive predictive values of 33% and 28%, and negative predictive values of 89% and 91% for predicting early cardiac events. A rate blood pressure product less than 12,000 with DSE was associated with an increased risk for postoperative atrial fibrillation. Correspondence analysis identified a statistical association between nonalcoholic steatohepatitis/cryptogenic cirrhosis and postoperative myocardial ischemia. Logistic regression identified 3 risk factors for postoperative acute coronary syndrome: age, history of coronary artery disease, and pretransplant requirement for vasopressors. Multivariable analysis showed statistical associations of the Model for End-Stage Liver Disease score and the development of acute kidney injury as risk factors for overall cardiac-related mortality. These findings may help in identifying high-risk patients and may lead to the development of better cardiac tests. Liver Transpl 21:13-21, 2015. V C 2014 AASLD.

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Section: Discussionsupporting

confidence: 90%

Adverse cardiac events after orthotopic liver transplantation: A cross‐sectional study in 389 consecutive patients

et al. 2014

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“…This finding is consistent with the absence of increased risks of myocardial infarction, stroke, and preclinical carotid atherosclerosis among patients with PBC and hypercholesterolemia [25][26][27]. The explanation for this protective effect remains largely unknown but may involve antioxidant properties of bilirubin [28], prevention of low-density lipoprotein oxidation by lipoprotein X [29], elevated serum levels of adiponectin [30], and FXR and TGR5 receptor activation [18].…”

Section: Discussionsupporting

confidence: 72%

Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis

Corpechot¹,

Chrétien²,

Chazouillères³

et al. 2010

Journal of Hepatology

203

181

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“…Abbasi et al performed Mendelian randomization in a prospective cohort of 3381 participants, used rs6742078 located in UGT1A 1, and found that elevated STBC is causally associated with the risk of DM [ 25 ]. Several studies also found that low-grade inflammation plays a critical role in the development of diabetic retinopathy [ 16 , 26 ]. Bilirubin also has anti-inflammatory properties through interfering with the expression of cell adhesion molecules, complement activity, and T cell differentiation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population

Zhang

Jin

et al. 2018

International Journal of Endocrinology

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Objective To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59.55 ± 10.63 years, and 43.5% of the subjects were women. The mean of DM duration was 11.01 ± 7.35 years. STBC were negatively correlated with DM duration, urea nitrogen, serum creatinine, uric acid, and urine microalbumin. After adjusting for confounding factors, as a continuous variable, STBC was inversely associated with the risk of DR in total subjects (OR: 0.95, 95% CI: 0.93–0.99). When STBC was used as a tertiary variable, compared with the first tertile, the OR in the third tertile was 0.37 (95% CI: 0.22–0.64) in total subjects. Conclusion Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR.

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Primary biliary cirrhosis and coronary atherosclerosis: Protective antioxidant effect of bilirubin

Cited by 12 publications

References 13 publications

Adverse cardiac events after orthotopic liver transplantation: A cross‐sectional study in 389 consecutive patients

Adverse cardiac events after orthotopic liver transplantation: A cross‐sectional study in 389 consecutive patients

Demographic, lifestyle, medical and familial factors associated with primary biliary cirrhosis

Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population

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