Primary biliary cholangitis has causal effects on systemic rheumatic diseases: a Mendelian randomization study
Hai-Ping Zhang,
Zhe Zhou,
Ke Chen
et al.
Abstract:Background
An association has been observed between primary biliary cholangitis (PBC) and systemic rheumatic diseases (SRDs) in observational studies, however the exact causal link remains unclear. We aimed to evaluate the causal effects of PBC on SRDs through Mendelian randomization (MR) analysis.
Methods
The genome-wide association study (GWAS) summary data were obtained from MRC IEU OpenGWAS and FinnGen databases. Independent genetic variants fo… Show more
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