Primary Benign Tumors of the Spinal Canal

Carlos-Escalante, José Alberto; Paz-López, Ángel Antonio; Cacho-Díaz, Bernardo; Pacheco-Cuellar, G.; Reyes-Soto, Gervith; Wegman-Ostrosky, Talía

doi:10.1016/j.wneu.2022.04.135

Cited by 13 publications

(6 citation statements)

References 193 publications

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“…NF1 causes tumors along the nervous system which can present as intraspinal or paraspinal tumors or in combination; they are noted in more than one-third of patients with NF1. 68 , 70 , 71 They are isolated neurofibromas or plexiform neurofibromas (with the incidence of 25%–50%). 69 Plexiform neurofibromas may be followed by pain, neurologic deficits, and deformity of adjacent structures.…”

Section: Tumorsmentioning

confidence: 99%

Tumors and infections of the growing spine

Jasiewicz,

Helenius

2023

Journal of Children's Orthopaedics

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The growing spine differs from the adult spine in several ways. Although tumors and infections cause only a small percentage of pediatric back pain incidences, delayed proper diagnosis and treatment may be disastrous. Benign lesions, such as osteoid osteoma, osteoblastoma, and aneurysmal bone cyst in the spine, are predominant during the first two decades of life, whereas malignant bony spinal tumors are rare. In the pediatric population, malignant spine tumors include osteosarcoma, Ewing’s sarcoma, lymphoma, and metastatic neuroblastoma. Infections of the growing spine are rare, with the incidence of discitis peaking in patients under the age of 5 years and that of vertebral osteomyelitis peaking in older children. Spondylodiscitis is often a benign, self-limiting condition with low potential for bone destruction. Conservative treatments, including bedrest, immobilization, and antibiotics, are usually sufficient. Spinal tuberculosis is a frequently observed form of skeletal tuberculosis, especially in developing countries. Indications for surgical treatment include neurologic deficit, spinal instability, progressive kyphosis, late-onset paraplegia, and advanced disease unresponsive to nonoperative treatment. Spinal tumors and infections should be considered potential diagnoses in cases with spinal pain unrelated to the child’s activity, accompanied by fever, malaise, and weight loss. In spinal tumors, early diagnosis, fast and adequate multidisciplinary management, appropriate en bloc resection, and reconstruction improve local control, survival, and quality of life. Pyogenic, hematogenous spondylodiscitis is the most common spinal infection; however, tuberculosis-induced spondylodiscitis should also be considered. Level of evidence: level 4.

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Section: Tumorsmentioning

confidence: 99%

Tumors and infections of the growing spine

Jasiewicz,

Helenius

2023

Journal of Children's Orthopaedics

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“…Malignant Schwann cell-derived tumors are rare and classified as malignant nerve sheath tumors (MNST) according to the WHO classification of 2016 [3,4]. Spinal schwannomas account for approximately 25% of all intradural spinal cord tumors [3,[5][6][7], with an incidence of 0.3-0.7 per 100,000 person years [8]. Tumors may be both intra-and extradural and may extend through the neural foramen to develop an hourglass or dumbbell shape [9].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Functional Outcomes Following Surgical Treatment of Spinal Schwannomas: A Population-Based Cohort Study

Singh,

Fletcher-Sandersjöö,

El-Hajj

et al. 2024

Cancers

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Spinal schwannomas are the second most common form of primary intradural spinal tumor. Despite being benign, they may cause spinal cord compression and subsequently acute or chronic neurological dysfunction. The primary treatment is surgical resection. The aim of this study was to identify pre- and postoperative predictors of favorable outcomes after surgical treatment for spinal schwannoma. All adult patients surgically treated for spinal schwannoma between 2006 and 2020 were eligible for inclusion. Medical records and imaging data were retrospectively reviewed. The primary outcome measures were neurological improvement according to the modified McCormick Scale (mMC) and changes in motor deficit, sensory deficit, gait disturbance, bladder dysfunction, and pain at long-term follow-up. In total, 180 patients with a median follow-up time of 4.4 years were included. Pain was the most common presenting symptom (87%). The median time between symptom presentation and surgery was 12 months, while the median time between diagnosis (first MRI) and surgery was 3 months. Gross total resection (GTR) was achieved in 150 (83%) patients and the nerve root could be preserved in 133 (74%) patients. A postoperative complication occurred in 10 patients (5.6%). There were significant postoperative improvements in terms of motor, sensory, gait, and bladder functions, as well as pain (p < 0.001). Of these symptoms, bladder dysfunction was the one most often improved, with complete symptom resolution in all cases. However, no other predictors of improvement could be identified. There were three cases of recurrence after GTR and nine cases of regrowth after STR. Reoperation was performed in six (3.3%) cases. GTR was associated with a significant improvement in neurological status at long-term follow-up and increased the chance of progression-free survival.

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“…Schwannomas are WHO grade 1 nerve sheath tumors that may affect peripheral, spinal, or cranial nerves [1][2][3][4]. Spinal schwannomas comprise 25% of all intradural spinal cord tumors [2,5,6] with an incidence of 0.3-0.7 per 100,000 [7]. Although benign, large schwannomas can compress nerve roots or the spinal cord, resulting in neurological deficits.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life and Return to Work after Surgery for Spinal Schwannoma: A Population-Based Cohort Study

Singh,

von Vogelsang,

El-Hajj

et al. 2024

Cancers

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Spinal schwannomas are the second most common primary intradural spinal tumor. This study aimed to assess health-related quality of life (HRQoL) and the frequency of return to work after the surgical treatment of spinal schwannomas. HRQoL was compared to a sample of the general population. Patients operated for spinal schwannomas between 2006 and 2020 were identified in a previous study and those alive at follow-up (171 of 180) were asked to participate. Ninety-four (56%) responded and were included in this study. Data were compared to the Stockholm Public Health Survey 2006, a cross-sectional survey of a representative sample of the general population. An analysis for any potential non-response bias was performed and showed no significant differences between the groups. HRQoL was equal between the spinal schwannoma sample and the general population sample in all but one dimension; men in the spinal schwannoma sample reported more moderate problems in the usual activities dimension than men in the general population (p = 0.020). In the schwannoma sample, there were no significant differences between men and women in either of the dimensions EQ-5Dindex or EQVAS. Before surgery, a total of 71 (76%) were working full-time and after surgery almost all (94%) returned to work, most of them within 3 months of surgery. Eighty-nine (95%) of the patients responded that they would accept the surgery for their spinal schwannoma if asked again today. To conclude, surgical treatment of spinal schwannomas is associated with good HRQoL and with a high frequency of return to work.

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Primary Benign Tumors of the Spinal Canal

Cited by 13 publications

References 193 publications

Tumors and infections of the growing spine

Tumors and infections of the growing spine

Long-Term Functional Outcomes Following Surgical Treatment of Spinal Schwannomas: A Population-Based Cohort Study

Health-Related Quality of Life and Return to Work after Surgery for Spinal Schwannoma: A Population-Based Cohort Study

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