Primary benign hypergammaglobulinemic purpura of waldenstrom masquerading as disseminated schamberg′s purpura

Nikam, Balkrishna P; Singh, Nishita J; Shetty, Deepa

doi:10.4103/0378-6323.77470

Cited by 1 publication

(2 citation statements)

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“…Additional findings can include leukopenia, anemia, and the presence of rheumatoid factor (RF). 6,9 Although HGPW is often associated with hypergammaglobulinemia, the pathogenesis remains unclear. A more specific feature may be the finding of immune complexes including IgG and IgA RF, which are believed to be involved in the development of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…HGPW usually presents clinically with mild itch, burning or tingling, and petechiae or purpura localized to the lower part of the legs. 6,9 This syndrome preferentially affects middle-aged women with skin findings resolving on their own within several days. 6,10,11 Laboratory investigations often reveal elevated levels of immunoglobulins, either IgG, IgM, or IgA or a combination.…”

Section: Discussionmentioning

confidence: 99%

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Hypergammaglobulinemic purpura of Waldenström—Unusual and impressive case in a patient with myeloma: A case report

DeBiasio

Cyr

Petkiewicz

et al. 2022

SAGE Open Medical Case Reports

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Background: Hypergammaglobulinemic purpura of Waldenström is an uncommon disease, which presents mostly in women on the lower extremities. It is sometimes associated with underlying immune dysregulation. Sjögren syndrome is the most common association; however, rare occurrences of the self-resolving syndrome with lymphoma or myeloma have been reported. Case Summary: We describe an unusual and impressive presentation of hypergammaglobulinemic purpura of Waldenström in an elderly female patient with myeloma. Notably, the patient did not have any concurrent connective tissue diseases. Despite her florid presentation, her hypergammaglobulinemic purpura of Waldenström spontaneously resolved within a few days. Conclusion: Hypergammaglobulinemic purpura of Waldenström is a self-resolving but recurrent syndrome, which may be associated with autoimmune disorders or rarely myeloma. Early diagnosis of the syndrome may avoid unnecessary treatment interventions and should prompt screening for underlying diseases.

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Section: Discussionmentioning

confidence: 99%