Primary Basal Cell Carcinoma of the Conjunctiva With Intraocular Invasion

A case of basal cell carcinoma of the nictitating membrane in a dog

“…Primary BCC of mucous membranes is extremely rare and often arise in areas of long‐term sun exposure . In humans, very few reports exist of primary BCC of the conjunctiva or caruncle . In the veterinary literature, there was only one report of a basal cell tumor involving the third eyelid of a horse .…”

Primary basal cell carcinoma of the caruncle with seeding to the conjunctiva

“…BCC is the third most frequent invading orbital malignancy (10%), only next to choroidal malignant melanoma (55%) and squamous cell carcinoma (15%) [6]. Or- [3] bital invasion by BCCs can be fatal due to intracranial extension [7]. Although BCC most often is restricted to lateral growth, the tumour cells in the orbit in this case exhibited a perineural and perivascular growth pattern which could have facilitated the tumour to traverse the subcaruncular fatty tissue.…”

“…Only four well-illustrated primary BCCs of the conjunctiva have been reported [1][2][3]5]. Clinically, conjunctival BCC tends to mimic papillomas [5].…”

“…Clinically, conjunctival BCC tends to mimic papillomas [5]. Of the previous reports, one was located at the nasal-and one at the temporal limbus, and both were described as nodular [3,5]. The two other tumours were located in the palpebral aperture between the plica and limbus and were described as pedunculated [1,2] (Table 1).…”

“…Primary BCC of mucous membranes is extremely rare [7] and the majority of BCCs of the conjunctiva are due to invasion from the periocular skin [4]. Only two primary BCCs of the caruncle [8,9] and four of the conjunctiva have been reported previously [1][2][3]5].…”