Primary B Cell Lymphoma of the External Auditory Canal

Hersh, Sheldon P.; Harrison, Winston; Hersh, D.

doi:10.1177/014556130608500912

Cited by 13 publications

(14 citation statements)

References 12 publications

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“…Most primary lymphomas of the head and neck are of the NHL variety and are generally extranodal in location at initial presentation occurring most commonly in the nasopharynx, lacrimal sac, and the temporal bone [10]. Primary lymphoma of the temporal bone involves the mastoid, middle ear most commonly, and the external/internal auditory canals to a lesser degree [6]. A layer of lymphoid tissue located deep to the epithelium of the mucosa lining the mastoid antrum, tympanic cavity, and tympanic orifice of the eustachian tube acts as the site of origin of the primary lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…Non-Hodgkin's lymphoma (NHL) is the second most common malignancy found in the head and neck region after squamous cell carcinoma [3, 4]. Involvement of the temporal bone as part of generalized lymphoma has been reported [5, 6]; however, primary involvement of temporal bone without systemic involvement is extremely rare [7]. High resolution multiplanar CT and MRI were useful in demonstrating the local infiltration into overlying soft tissues as well as extension to intracranial compartment.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral Non-Hodgkin’s Lymphoma of the Temporal Bone: A Rare and Unusual Presentation

Vaid¹,

Jadhav²,

Chandorkar³

et al. 2016

Case Reports in Otolaryngology

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Primary lymphoma of the temporal bone is an unusual finding in clinical practice and bilateral affection is even more rare. To the best of our knowledge, there are no reports of bilateral primary temporal bone lymphoma without middle ear involvement in the English medical literature so far. We report, for the first time, a case of primary lymphoma involving both temporal bones which presented with left-sided infranuclear facial palsy. A combination of contrast enhanced magnetic resonance imaging (MRI) and high resolution computed tomography (HRCT) was used to characterize and to map the extent of the lesion, as well as to identify the exact site of facial nerve affection. An excision biopsy and immunohistochemistry revealed diffuse large B-cell non-Hodgkin's lymphoma (DLBCL). Whole body fluorodeoxyglucose (FDG) positron emission tomography-computed tomography study (PET-CT) was performed to stage the disease. The patient was treated with chemotherapy and radiation therapy and is now on regular follow-up. The patient is alive and asymptomatic without disease progression for the last twenty months after initial diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bilateral Non-Hodgkin’s Lymphoma of the Temporal Bone: A Rare and Unusual Presentation

Vaid¹,

Jadhav²,

Chandorkar³

et al. 2016

Case Reports in Otolaryngology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Involvement of the temporal bone as part of generalized lymphoma has been reported; however, clinical evidence of temporal bone or middle ear involvement is unusual [3, 4, 5, 6]. Presentation with otoneurological signs prior to systemic involvement of a lymphoproliferative disease is also unusual [5]. To our knowledge, only 10 cases of malignant lymphoma originating around the middle ear have been reported (table 1) [1, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14].…”

Section: Discussionmentioning

confidence: 99%

“…Presentation with otoneurological signs prior to systemic involvement of a lymphoproliferative disease is also unusual [5]. To our knowledge, only 10 cases of malignant lymphoma originating around the middle ear have been reported (table 1) [1, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14]. In the previous 10 reports, the lesion was located in the middle ear in 3, internal in 3, and external in 4.…”

Section: Discussionmentioning

confidence: 99%

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B-Cell Malignant Lymphoma Presenting as Otitis Media and Mastoiditis Associated with Sinus Thrombosis

et al. 2014

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Cerebral venous thrombosis as a manifestation of paraneoplastic angitis and otitis media, revealing non-Hodgkin B-cell lymphoma (NHBL), is extremely rare. A 57-year-old woman presented with headache, auditory disturbance and recalcitrant otitis media. Magnetic resonance imaging showed brain edema in the temporal lobe and transverse sinus thrombosis. External drainage under antibiotic treatment was repeated based on a diagnosis of invasive otitis media and mastoiditis associated with infectious sinus thrombosis, but the condition deteriorated progressively. Open surgery for otitis media was performed 6 years after the initial symptoms and after a tumorous lesion had been detected in the middle ear. Pathological findings revealed NHBL. We report a rare case of NHBL presenting as otitis media and mastoiditis associated with sinus thrombosis, and a literature review.

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Identification of a homozygous frameshift mutation in the FGF3 gene in a consanguineous Iranian family: First report of labyrinthine aplasia, microtia, and microdontia syndrome in Iran and literature review

Jamshidi

Shokouhian

Mohseni

et al. 2023

Molec Gen & Gen Med

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Background To date, over 400 syndromes with hearing impairment have been identified which altogether constitute almost 30% of hereditary hearing loss (HL) cases around the globe. Manifested as complete or partial labyrinthine aplasia (severe malformations of the inner ear structure), type I microtia (smaller outer ear with shortened auricles), and microdontia (small and widely spaced teeth), labyrinthine aplasia, microtia, and microdontia (LAMM) syndrome (OMIM 610706) is an extremely rare autosomal recessive condition caused by bi‐allelic mutations in the FGF3 gene. Methods Using the whole‐exome sequencing (WES) data of the proband, we analyzed a consanguineous Iranian family with three affected members presenting with congenital bilateral HL, type I microtia, and microdontia. Results We discovered the homozygous deletion c.45delC in the first exon of the FGF3 gene, overlapping a 38.72 Mb homozygosity region in chromosome 11. Further investigations using Sanger sequencing revealed that this variant co‐segregated with the phenotype observed in the family. Conclusion Here, we report the first identified case of LAMM syndrome in Iran, and by identifying a frameshift variant in the first exon of the FGF3 gene, our result will help better clarify the phenotype–genotype relation of LAMM syndrome.

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Primary B Cell Lymphoma of the External Auditory Canal

Cited by 13 publications

References 12 publications

Bilateral Non-Hodgkin’s Lymphoma of the Temporal Bone: A Rare and Unusual Presentation

Bilateral Non-Hodgkin’s Lymphoma of the Temporal Bone: A Rare and Unusual Presentation

B-Cell Malignant Lymphoma Presenting as Otitis Media and Mastoiditis Associated with Sinus Thrombosis

Identification of a homozygous frameshift mutation in the FGF3 gene in a consanguineous Iranian family: First report of labyrinthine aplasia, microtia, and microdontia syndrome in Iran and literature review

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