Primary B‐cell lymphoma and lymphoma‐like lesions of the uterine cervix

Au, Wing Y.; Chan, Ben; Chung, Lap-Ping; Choy, Carolyn

doi:10.1002/ajh.10334

Cited by 33 publications

(36 citation statements)

References 16 publications

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“…It is noteworthy that also the possibility of a lymphoma-like lesion should always be taken into account when confronted with a localized, superficial DLBCL of the female genital tract. Such a condition has been described for cervical, endometrial and vulvar lesions [37,38,39]. It is still not clear what it exactly represents.…”

Section: Discussionmentioning

confidence: 99%

Primary Extranodal Non-Hodgkin’s Lymphoma of the Vagina: A Case Report and a Review of the Literature

Guastafierro

Tedeschi²,

Criscuolo³

et al. 2012

Acta Haematol

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Primary lymphoma of the female genital tract is very rare. We report the case of a 36-year-old woman who was referred to our hospital because of an indeterminate Pap smear test. The colposcopy showed a thickening of the posterior vaginal wall and various irregular ulcerated nodular lesions. Histological examination, immunohistochemistry and the staging procedures were conclusive of diffuse large B-cell lymphoma of the vagina, stage IEA. Complete remission was achieved after 6 cycles of immunopolychemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). No relapse has occurred during a follow-up of 71 months. Moreover, we reviewed the 62 previously reported cases of primary extranodal non-Hodgkin’s lymphoma of the vagina, focusing on clinicopathological and therapeutic aspects, to better characterize this unusual disease.

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Section: Discussionmentioning

confidence: 99%

Primary Extranodal Non-Hodgkin’s Lymphoma of the Vagina: A Case Report and a Review of the Literature

Guastafierro

Tedeschi²,

Criscuolo³

et al. 2012

Acta Haematol

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“…Whereas Au et al [16] discouraged any conservative approach in case of bulky cervical lymphomas, some reports of conservative approach have documented excellent results in terms of cure of the disease [3, 9, 12, 13]. Moreover, Perren et al [6], following an extensive revision of the literature, concluded that there is no evidence that radical surgery confers more survival advantages than conservative surgery in patients with localized and low- or intermediate-grade tumors.…”

Section: Discussionmentioning

confidence: 99%

Successful Pregnancy in Stage IE Primary Non-Hodgkin’s Lymphoma of Uterine Cervix Treated with Neoadjuvant Chemotherapy and Conservative Surgery

Lorusso¹,

Ferrandina

Pagano

et al. 2007

Oncology

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Background: Primary non-Hodgkin’s lymphoma involving the uterine cervix is extremely rare with a frequency of 0.008% of all cervical tumors. No standard treatment has been defined for this disease. Case: A 29-year-old Caucasian woman with primary non-Hodgkin stage IE lymphoma of the uterine cervix was treated with neoadjuvant chemotherapy and conservative surgery. Three years after completion of primary treatment, she became pregnant and successfully delivered a full-term healthy baby. Conclusion: This case report supports the data that a conservative strategy consisting of neoadjuvant chemotherapy followed by a uterine-preserving approach represents an adequate option for young highly motivated patients who desire to preserve the childbearing potential.

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“…Reactive lymphoid proliferations of the lower gynecologic tract are usually associated with infections and surgical procedures [2,4], and display a mixed cellular and phenotypic composition [2,3,4] although, at times, they may appear so exuberant that a diagnosis of a lymphoma has to be considered in the differential diagnosis, especially in case of monoclonal IgH gene rearrangement [3,4]. However, primary uterine non-Hodgkin's lymphomas are rare, and most of them are of peripheral B-cell origin [8,9], while primary T-cell ones are exceedingly rare and most often belong to the aggressive subtypes of the WHO categories [5,6,7,8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory lesions of the uterus are common and mainly involve the cervix and the endometrium; sometimes they can be so florid that the term ‘lymphoma-like lesions' (LLLs) has been coined [1,2]; LLLs have been associated with infections or surgical procedures [2,3] and are generally histologically characterized by a polymorphous lymphoid infiltrate with a variable range of B and T lymphocytes and plasma cells. Such processes are generally centered in the mucosa, and neither penetrate the deep uterine stroma nor form macroscopic masses.…”

Section: Introductionmentioning

confidence: 99%

A Unique Case of an Indolent Myometrial T-Cell Lymphoproliferative Disorder with Phenotypic Features Resembling Uterine CD8+ Resident Memory T Cells

Tabanelli

Valli²,

Righi

et al. 2014

Pathobiology

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Objective: Indolent extranodal T-cell lymphoproliferative disorders have recently been described as new entities in the gastrointestinal tract and acral sites displaying clonal T-cell receptor (TCR) rearrangement and nonactivated cytotoxic CD8+ T-cell phenotypes. Methods/Results: We report a unique case of an atypical myometrial T-cell lymphoproliferation in a 39-year-old multiparous woman, which shares many of the features mentioned above: CD8+/TIA1+/granzyme B- phenotype, clonal TCR rearrangement and indolent course. Conclusion(s): We hypothesize that it might derive from a subset of uterine nonrecirculating CD8+ resident memory T cells expanded after repeated exposure to allo-extravillous trophoblastic antigen.

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Primary B‐cell lymphoma and lymphoma‐like lesions of the uterine cervix

Cited by 33 publications

References 16 publications

Primary Extranodal Non-Hodgkin’s Lymphoma of the Vagina: A Case Report and a Review of the Literature

Primary Extranodal Non-Hodgkin’s Lymphoma of the Vagina: A Case Report and a Review of the Literature

Successful Pregnancy in Stage IE Primary Non-Hodgkin’s Lymphoma of Uterine Cervix Treated with Neoadjuvant Chemotherapy and Conservative Surgery

A Unique Case of an Indolent Myometrial T-Cell Lymphoproliferative Disorder with Phenotypic Features Resembling Uterine CD8+ Resident Memory T Cells

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