Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: A<scp>V</scp>eterinary<scp>S</scp>ociety of<scp>S</scp>urgical<scp>O</scp>ncology retrospective study

Giuffrida, Michelle A.; Kamstock, Debra A.; Selmic, Laura E.; Pass, William E; Szivek, Anna; Mison, Michael B.; Boston, Sarah E.; Fox, Leslie E.; Robat, Cecilia; Grimes, Janet A.; Maritato, Karl C.; Bacon, Nicholas J.

doi:10.1111/vsu.12926

Cited by 6 publications

(14 citation statements)

References 24 publications

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“…89 However, low numbers of canine and feline cases are reported, many have scant descriptions of the diagnostic imaging findings, and at least one published image appeared to show marked periosteal reaction or amorphous bone. 1,12,34 Additionally, more recent reports of the disease in humans have identified subtle matrix mineralization contrary to earlier literature, making differentiation of telangiectatic osteosarcoma on the basis of imaging characteristics alone ill-advised. Diagnostic imaging can be used to identify the geographic center of a lesion, as well as the predominant aspect of any lysis—periosteal versus endosteal, for example—and may therefore be used to characterize osteosarcoma as parosteal, periosteal or central.…”

Section: Is the Tumor Benign Or Malignant?mentioning

confidence: 94%

“…Additionally, half of the primary appendicular hemangiosarcoma cases occurred in the tibia, and these findings may help rank differential diagnoses prior to immunohistochemistry. 34 Disease staging due to presence of an aggressive bone lesion usually includes thoracic and abdominal screening by radiography, ultrasonography or CT. Presence of pleural or peritoneal effusion, splenomegaly, splenic mass, right atrial mass, or pericardial effusion raise concern for metastatic hemangiosarcoma, whereas these findings are expected much less frequently with metastatic osteosarcoma or coincidental comorbidities.…”

Section: Osteosarcoma Versus Other Sarcomas Of Bonementioning

confidence: 99%

“…4,57 Similarly, telangiectatic osteosarcoma has been associated with a shorter survival time in some studies but not others. 34,42,78,83 The problem with many studies examining tumor subtype and survival time is the small number of each subtype, making it challenging to draw well-supported conclusions.…”

Section: Parosteal Versus Periosteal Versus Central Osteosarcomamentioning

confidence: 99%

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A Holistic Approach to Bone Tumors in Dogs and Cats: Radiographic and Histologic Correlation

Dittmer

Pemberton

2021

Vet Pathol

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The skeletal system is a common site for neoplasia in dogs and cats, and primary bone tumors may develop from any of the mesenchymal tissues present in bone. Imaging and histopathology are routinely used in the diagnosis of bone tumors, and the 2 techniques are highly complementary. While imaging may be highly suggestive of a specific diagnosis and treatment may be instituted based on this, definitive diagnosis requires histopathology of either incisional or excisional biopsies or an amputation specimen. However, there are a number of diagnostic dilemmas when the pathologist interprets bone biopsy samples, such as distinguishing reactive bone and tumor bone, fracture callus and tumor bone, different benign fibro-osseous lesions, and different types of bone sarcoma. This review outlines the characteristic radiographic and histologic changes associated with these diagnostic problems to aid in resolving them. When a holistic approach is taken to evaluation of the signalment, history, and clinical, radiologic, and microscopic features, a diagnosis may be possible. The pathologist is greatly assisted in the interpretation of bone samples by having access to imaging and should routinely request either the images or the imaging reports if they are not received from submitting veterinarians.

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Section: Is the Tumor Benign Or Malignant?mentioning

confidence: 94%

Section: Osteosarcoma Versus Other Sarcomas Of Bonementioning

confidence: 99%

Section: Parosteal Versus Periosteal Versus Central Osteosarcomamentioning

confidence: 99%

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A Holistic Approach to Bone Tumors in Dogs and Cats: Radiographic and Histologic Correlation

Dittmer

Pemberton

2021

Vet Pathol

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“…Hemangiosarcoma tends to be aggressively invasive and metastasises readily 1 2 10. Despite removal of the primary bone tumour via amputation, the prognosis has been poor due to progressive metastasis 2 11. This report describes a case of primary bone hemangiosarcoma involving digit 4 in a Siberian husky.…”

Section: Introductionmentioning

confidence: 96%

Primary bone hemangiosarcoma involving the 4th digit in a Siberian Husky dog

Moon

Hillers

Kim

2020

Vet Record Case Reports

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An 11-year-old female spayed Siberian Husky was presented with a left hind, swollen, bleeding mass involving digit 4. Radiographs revealed osteolytic lesions involving the distal phalanx (P3) and part of the middle phalanx (P2). Digit amputation was performed; histopathology was consistent with hemangiosarcoma. Although no signs of systemic involvement were detected around the time of amputation, the patient was euthanised 47 days later due to regional and distant metastasis.

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“…TOS consists of multiple characteristic dilated aneurysmal cavities containing blood, with highly malignant sarcoma cells being present at the peripheral margins and septations surrounding these cavities (7). As this is a very rare form of cancer, no largescale clinical studies of TOS have been conducted to date, and case reports (8)(9)(10) and animal studies (11)(12)(13) thus account for the bulk of research related to this condition. Given these limitations, the clinical characteristics and prognosis of TOS remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and prognosis of telangiectatic osteosarcoma: a population-based study using the Surveillance, Epidemiology and End Results (SEER) database

Xu¹,

Dai²,

Yang³

et al. 2021

Ann Transl Med

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Background: Telangiectatic osteosarcoma (TOS) is a rare type of osteosarcoma for which limited clinical data is available. Furthermore, the clinical characteristics and prognosis of TOS remain unclear.Methods: A large population-based cohort analysis was conducted using the Surveillance, Epidemiology and End Results (SEER) registry. The data of TOS and conventional osteosarcoma (COS) patients from 2000 to 2017 were collected. The categorical variables were assessed by Chi-squared tests. Kaplan-Meier curves and log-rank (Mantel-Cox) tests were used to examine the survival outcomes between the groups.Cox proportional hazard models were used for univariate and multivariate analyses of TOS patient survivalrelated variables.Results: A total of 141 TOS patients and 2961 COS patients were included in this analysis, and the mean age at diagnosis was 23.5 and 29.4 years, respectively. Compared to COS patients, TOS patients were more likely to be under 20 years old (61.7% vs. 51.7%, P=0.022), and without a second peak of incidence after 60 years of age. The median overall survival (mOS) of TOS patients was not reached compared to a median survival of 84 months for COS patients (hazard ratio 0.75, 95% confidence interval 0.59 to 0.95, P=0.0175).After adjusting these data for age at diagnosis, stage, and surgery at the primary site, no significant differences in mOS were observed between the two groups. In univariate analyses, being under 20 years of age, having localized or regional stage disease, and having undergone surgery were associated with a decreased risk of death. Subsequent multivariate analysis indicated that age at diagnosis, stage, and surgery at the primary site were all independent predictors of prognosis in TOS patients.Conclusions: Patients with TOS were younger than patients with COS and did not show a second peak after 60 years of age. Age, summary stage at diagnosis, and surgery at the primary site were independent predictors of survival for TOS patients.

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Primary appendicular hemangiosarcoma and telangiectatic osteosarcoma in 70 dogs: AVeterinarySociety ofSurgicalOncology retrospective study

Cited by 6 publications

References 24 publications

A Holistic Approach to Bone Tumors in Dogs and Cats: Radiographic and Histologic Correlation

A Holistic Approach to Bone Tumors in Dogs and Cats: Radiographic and Histologic Correlation

Primary bone hemangiosarcoma involving the 4th digit in a Siberian Husky dog

Characteristics and prognosis of telangiectatic osteosarcoma: a population-based study using the Surveillance, Epidemiology and End Results (SEER) database

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