Primary Appendiceal Adenocarcinoma

Özakyol, Ayşegül; Sarıçam, Tülay; Kabukçuoğlu, Sare; Çağa, Tarık; Erenoğlu, Esat

doi:10.1097/00000421-199910000-00007

Cited by 32 publications

(21 citation statements)

References 5 publications

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“…Appendiceal adenocarcinoma is a rare cancer and constitutes <0.5% of all gastrointestinal neoplasms (32). Because there are no specific or early symptoms, it is very difficult to diagnosis preoperatively.…”

Section: Discussionmentioning

confidence: 99%

Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Feltmate

Lee

Johnson

et al. 2005

Clinical Cancer Research

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Purpose: Mucinous adenocarcinoma of the ovary is one of the common histologic types of ovarian cancer. Its pathogenesis is largely unknown. In addition, the differential diagnosis of metastatic mucinous carcinomas to the ovaries, particularly those originating from the appendix, remains challenging. The purpose of this study is to identify molecular biomarkers for mucinous ovarian adenocarcinoma and compare them with those of appendiceal origin. Experimental Design: Genome-wide loss-of-heterozygosity (LOH) analysis was done on DNA isolated from 28 microdissected primary mucinous ovarian carcinomas and five appendiceal adenocarcinomas. Markers from high-loss regions were selected for further analysis on a total of 32 ovarian and 14 appendiceal cancers. Results: High levels of LOH rates (>40%) were detected on chromosome arms 9p,17p, and 21q in mucinous ovarian carcinoma cases. The frequency of allelic loss was similar between high-grade and low-grade mucinous ovarian carcinoma cases but was significantly higher in ovarian versus appendiceal cases. In addition, LOH rates on five chromosomal loci were statistically different between ovarian and appendiceal carcinomas. Conclusion: A high frequency of LOH can be found in mucinous ovarian adenocarcinomas independent of grade. Despite histologic similarities between mucinous ovarian carcinomas and metastatic appendiceal carcinomas, they have distinct LOH profiles, which may be used for distinguishing the two diseases.

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Section: Discussionmentioning

confidence: 99%

Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Feltmate

Lee

Johnson

et al. 2005

Clinical Cancer Research

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“…The histopathology and clinical outcomes of appendicular adenocarcinoma have been studied previously, and perforation is known to be common in appendicular adenocarcinoma patients. However, peritoneal implantation due to perforation is discussable (10). Surgical treatment for appendicular adenocarcinoma has controversies.…”

Section: Discussionmentioning

confidence: 99%

Appendix adenocarcinoma in an elderly patient from a nursing home

Sönmez

Bayhan

Yaylak

et al. 2016

UCD

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Appendiceal malignancies are rare clinic entities. The clinical presentation of appendiceal malignancies is often atypical. Acute abdominal pain and acute appendicitis, which requires early surgical intervention, are the most common clinical presentations of appendiceal malignancies. In this case report, an adenocarcinoma of the appendix in a 64-year-old male from a nursing home has been presented. He had right lower quadrant pain for the last 5 days. On physical examination, he had significant guarding. Intravenous contrast-enhanced abdominopelvic tomography revealed no pathological features. Laparotomy under general anesthesia was scheduled. During exploration, a perforated appendicitis was observed. Formal appendectomy was performed. The patient was lost due to pneumonia and septic shock 5 days after surgical intervention. In addition, the natural history of the disease and its basic diagnostic and therapeutic aspects are discussed. Preoperative or intraoperative diagnosis may not be available for some patients. Thus, routine histopathological examination is essential for adequate diagnosis and treatment.

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“…Previous studies into the genetic alterations in appendiceal carcinoma has shown that it is distinct from colorectal cancer. [9] The molecular basis for the development of appendiceal mucinous tumours remains unclear. It has been shown that KRAS is frequently mutated in the majority of low-grade appendiceal neoplasms and mucinous adenocarcinomas, whereas GNAS mutation is only observed in of low-grade appendiceal neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Familial appendiceal tumours in Diffuse Peritoneal Adenomucinosis and peritoneal mucinous carcinomatosis: A rare familial predisposition?

Davies

Doyle

Tran

et al. 2016

CSS

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Epithelial neoplasms of the appendix are rare. They account for an annual age adjusted incidence of 4 cases per 1,000,000. The low incidence of primary appendix tumours means that there are very few published reports of the familial occurrence. This case series reports two cases of primary appendiceal epithelial tumours in two sets of relatives. A genetic evaluation was performed to determine if there was any underlying single gene disorder, which could account for the familial occurrence. The results showed there was no DNA mismatch repair defect evident. This means that the occurrence of appendiceal cancer in siblings may represent a random event. However, exceedingly rare predisposition syndrome cannot be ruled out from our analysis.

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Primary Appendiceal Adenocarcinoma

Cited by 32 publications

References 5 publications

Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Appendix adenocarcinoma in an elderly patient from a nursing home

Familial appendiceal tumours in Diffuse Peritoneal Adenomucinosis and peritoneal mucinous carcinomatosis: A rare familial predisposition?

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