Primary Aortic Mural Thrombus: Presentation and Treatment

Hahn, Tara L.; Dalsing, Michael C.; Sawchuk, Alan P.; Cikrit, Dolores F.; Lalka, Stephen G.

doi:10.1007/s100169900220

Cited by 69 publications

(68 citation statements)

References 15 publications

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“…For up to 70 years, it has been known that inflammatory bowel disease is associated with venous but also arterial thrombosis (13)(14)(15)(16)(17)(18)(19)(20)(21). The incidence ranges from 1.2% to 6.1% according to different studies and up to 39% in autopsy studies (22).…”

Section: Cvd In CDmentioning

confidence: 99%

Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease

Leuven

Hezemans

Levels

et al. 2007

Journal of Lipid Research

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A chronic inflammatory state is a risk factor for accelerated atherogenesis. The aim of our study was to explore whether Crohn's disease (CD), characterized by recurrent inflammatory episodes, is also associated with accelerated atherogenesis. In 60 CD patients and 122 matched controls, carotid intima media thickness (IMT), a validated marker for the burden and progression of atherosclerosis, was assessed ultrasonographically. Additional subgroup analyses, including plasma levels of acute phase reactants and HDL protein profiling, were performed in 11 consecutive patients with CD in remission, 10 patients with active CD, and 15 healthy controls. Carotid IMT in patients with CD was increased compared with healthy volunteers: 0.71 (0.17) versus 0.59 (0.14) mm (P , 0.0001), respectively. In the subgroup analysis, HDL levels in controls and patients in remission were identical [(1.45 (0.48) and 1.40 (0.46) mmol/l; P 5 0.797], whereas HDL during exacerbation was profoundly reduced: 1.02 (0.33) (P 5 0.022). HDL from patients with active CD and CD patients in remission was characterized by a reduced ability to attenuate oxidation compared with controls (P 5 0.008 and P 5 0.024 respectively). Patients with CD have increased IMT compared with matched controls, indicative of accelerated atherogenesis. The changes during CD exacerbation in terms of HDL concentration and composition imply a role for impaired HDL protection in these patients.-van

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Section: Cvd In CDmentioning

confidence: 99%

Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease

Leuven

Hezemans

Levels

et al. 2007

Journal of Lipid Research

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“…TAMT has rarely been mentioned in the literature, and described as primary, spontaneous, non-occlusive aortic thrombus [3]; Williams et al [4] in 1981 first described a mobile thrombus in the aorta [7]. More recently, Bowdish et al [1] suggested using the term TAMT, which defined aortic thrombi that develop in the absence of pre-existing aortic disease [1].…”

Section: Discussionmentioning

confidence: 99%

“…At the present time, management of TAMT remains unclear [2,3]. We present a case of TAMT, causing peripheral embolic occlusion, successfully managed with endovascular stent graft (SG) as the primary therapeutic approach.…”

Section: Introductionmentioning

confidence: 99%

Endovascular treatment for mobile thrombus of the thoracic aorta

Piffaretti

Tozzi

Caronno

et al. 2007

European Journal of Cardio-Thoracic Surgery

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Detection levels of mobile thrombus of the thoracic aorta have greatly increased after any embolic event. Although the indication for treatment remains controversial, there is a growing interest about the etiopathogenesis of this rare entity and to define proper diagnostic and therapeutic approaches. We present a case of mobile thrombus of the thoracic aorta causing recurrent peripheral emboli managed with endovascular stent graft. #

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“…A variety of approaches are used, including conservative treatment with anticoagulation or thrombolysis, interventional modalities such as thromboaspiration, or balloon-catheter thrombectomy, and open surgical procedures such as thrombectomy, thromboendarterectomy, and aortic prosthetic replacement. [12][13][14][15][16] Given currently available data from literature showing a high risk of recurrence, and a potentially high rate of operative mortality/ morbidity of thoracotomy, medical therapy with anticoagulation is considered the first option for this rare, but potentially devastating disease. 17) In the present case, TEE allowed us to rule out other aortic diseases and raised the suspicion of aortic thrombus in young patient without any predisposing factor for vascular thrombosis, based on which anticoagulation therapy was initiated.…”

Section: )11)mentioning

confidence: 99%

A Case of Huge Thrombus in the Aortic Arch with Cerebrovascular Embolization

Song

Hong

Cho

et al. 2009

J Cardiovasc Ultrasound

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Pedunculated thrombus in the aortic arch that is associated with cerebral infarction is very rare requires prompt diagnosis and treatment to prevent occurrence of another devastating complication. Transesophageal echocardiography is useful for detecting source of embolism including aortic thrombi. The treatment options of aortic thrombi involves anticoagulation, thrombolysis, thromboaspiration, and thrombectomy. Here we report a case of huge thrombus in the aortic arch, resulting in acute multifocal cerebellar embolic infarct in patient without any risk factors for vascular thrombosis. Thrombi in the aortic arch were diagnosed by transesophageal echocardiography and treated with anticoagulants successfully.

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Primary Aortic Mural Thrombus: Presentation and Treatment

Cited by 69 publications

References 15 publications

Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease

Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease

Endovascular treatment for mobile thrombus of the thoracic aorta

A Case of Huge Thrombus in the Aortic Arch with Cerebrovascular Embolization

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