Primary antibody deficiency in adults

Spickett, GP; Misbah, Siraj; Chapel, Helen

doi:10.1016/0140-6736(91)90882-p

Cited by 70 publications

(45 citation statements)

References 16 publications

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“…Soluble CD8 antigen appears to be released from CD8 þ lymphocytes upon activation [23,24]. The decrease in sCD8 antigen/CD8 þ lymphocyte ratio may indicate that the amount of sCD8 antigen attributable to individual cells is significantly decreased after IVIG infusion [12,24], and although we did not examine any direct functional activity of CD8 þ lymphocytes, the present findings may suggest a down-modulation of CD8 þ lymphocyte activity in vivo after IVIG administration. In contrast, the rise in plasma neopterin levels suggests in vivo activation of monocytes/macrophages.…”

Section: Discussioncontrasting

confidence: 44%

“…Twelve patients (four males and eight females; median age 39 years, range 20-60 years) under treatment at the Section of Clinical Immunology and Infectious Diseases, Medical Department A, The National Hospital, Oslo, Norway, with the diagnosis of primary hypogammaglobulinaemia based on established criteria [11,12], were included in the study. Ten patients were classified as common variable immunodeficiency and two as congenital hypogammaglobulinaemia as previously described [13,14].…”

Section: Patientsmentioning

confidence: 99%

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Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

Aukrust

Müller

Nordøy

et al. 1997

Clinical and Experimental Immunology

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SUMMARYIn 12 patients with primary hypogammaglobulinaemia we investigated the in vivo effect of one bolus injection (400 mg/kg) of intravenous immunoglobulin (IVIG) on lymphocyte subsets and monocytes in peripheral blood, on plasma levels of soluble factors reflecting monocyte and lymphocyte activity and on lymphocyte proliferation and generation of reactive oxygen species (ROS) from monocytes analysed in vitro. Several immunological changes were induced by IVIG infusion. First, there was a significant decrease in CD4 þ /CD8 þ lymphocyte ratio in peripheral blood, reflecting a significant increase in circulating numbers of CD8 þ lymphocytes. Second, although there was no significant change in plasma levels of soluble CD8 antigen, there was a significant decrease in soluble CD8 antigen/CD8 þ lymphocyte ratio, suggesting a down-regulation of CD8 þ lymphocyte activity. Third, there was a significant increase in plasma levels of neopterin, suggesting in vivo activation of monocytes/ macrophages. Fourth, the was a down-modulation of mitogen-stimulated lymphocyte proliferation in vitro, and this down-regulation was significantly correlated with the increase in plasma neopterin levels. Finally, there was a significant decrease in zymosan-stimulated, but not in phorbol myristate acetatestimulated, ROS generation from monocytes as evaluated by nitroblue tetrazolium reduction. The ability of IVIG administration in vivo to down-modulate lymphocyte proliferation and ROS generation from monocytes in patients with persistent immune activation may be relevant for the clinical effects of IVIG in a variety of immune-mediated disorders.

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Section: Discussioncontrasting

confidence: 44%

Section: Patientsmentioning

confidence: 99%

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

Aukrust

Müller

Nordøy

et al. 1997

Clinical and Experimental Immunology

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“…Furthermore, although 60% of the XLA patients had diagnosed bronchiectasis, no significant alterations of ROS generation was demonstrated. Indeed, the present study illustrates that unlike CVI patients, substantial monocyte/macrophage as well as T cell abnormalities are uncommon among XLA patients [1,14].…”

Section: Discussionmentioning

confidence: 96%

“…Oslo. The diagnosis of primary hypogammaglobulinaemia was based on established criteria [1,13]. All patients had severely reduced serum IgG levels in at least two serum samples and had experienced recurrent sinopulmonary infections before immunoglobulin substitution therapy was started.…”

Section: Patients and Controlsmentioning

confidence: 99%

“…The c!inical manifestations are characterized by recurrent infections, particu!arly in the respiratory tract, and high incidence of lymphoid and gastrointestinal malignancies, autoimmune disorders, non-caseating granulomata and nonmalignant lymphoid hyperplasia [1], There is evidence that the B eel! defect in these patients is often associated with abnormalities of T eel!…”

Section: Introductionmentioning

confidence: 99%

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Enhanced generation of reactive oxygen species in monocytes from patients with common variable immunodeficiency

Aukrust¹,

Müller

Ss³

1994

Clinical and Experimental Immunology

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SUMMARYMonocyte and macrophage dysfunction may be important for both immunopathogenesis and c!inica! manifestations in subgroups ofpatients with primary hypogammaglobulinaemia. In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different methods: superoxide dismutase (SOD) inhibitable cytochrome c reduction by Oi and nitrobiuc tetrazolium (NBT) reduction. Monocytes from patients with common variable immunodeficiency (CVI) demonstrated significantly enhanced ROS generation both unstimulated and stimulated (unopsonized zymosan and phorbol myristate acetate (PMA)). The enhanced oxidative burst response in CV! patients was found both with and without scrum containing medium. Furthermore, serum from CVI patients did significantly enhance the oxidative burst response in monocytes from healthy hlood donors compared with the effect of control serum. The enhanced ROS generation in CVI patients was significantly correlated with elevated serum levels of neopterin, reduced numbers of CD4' lymphocytes in peripheral blood and occurrence of splenomegaly. !n contrast to the CV! group, monocytes from patients with X-linked agammaglobulinaemia (XLA) did not show enhanced ROS generation. The increased oxidative burst response in monocytes frotn CV! patients most probably reflects in vivo activation of these cells. Our observations indicate the presence of a subgroup of CVI patients characterized by chronic immune activation particularly of monocytes. The enhanced ROS generation might be involved in immunopathogenesis (e.g. T cell dysfunction) and in the pathogenesis of clinica! manifestations (e.g. malignancies and autoimmune disorders) in these patients.

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Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients

Cunningham‐Rundles

Bodian

1999

Clinical Immunology

1,334

1,207

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Primary antibody deficiency in adults

Cited by 70 publications

References 16 publications

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

Modulation of lymphocyte and monocyte activity after intravenous immunoglobulin administration in vivo

Enhanced generation of reactive oxygen species in monocytes from patients with common variable immunodeficiency

Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients

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