Primary angiosarcoma of the lung

Pandit, Sameer; Fiedler, Paul; Westcott, Jack L.

doi:10.1016/j.anndiagpath.2005.04.001

Cited by 46 publications

(41 citation statements)

References 10 publications

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“…The primary lesion of the present patient was thought to originate from the lung according to the clinical, pathological and radiological findings; however, pulmonary lesions are typically secondary and metastatic lesions from other primary lesions in patients with angiosarcoma (Kitagawa et al 1987). Primary pulmonary angiosarcoma is rare, and there have been only 32 case reports, including the present patient, six case reports in the Japanese literature (Oka et al 1981;Sasaki et al 1992;Ogura et al 1993;Kinoshita et al 2000;Asari et al 2003;Ogawa and Takaya 2014) and 25 reported cases in the overseas literature (Ott et al 1987;Sheppard et al 1997;Keel et al 1999;Atasoy et al 2001;Junge et al 2001;Kojima et al 2003;Maglaras et al 2004;Bouhaouala et al 2005;Corpa-Rodriguez et al 2005;Pandit et al 2005;Ozcelik et al 2006;Herrak et al 2007;Wilson et al 2008;Kuroda et al 2009;Chen et al 2010;Wan Musa et al 2010;Alayon-Laguer et al 2011;Eichner et al 2011;Kakegawa et al 2012;Yang et al 2012;Obeso Carillo et al 2013;Treglia et al 2014) reported thus far. Table 1 represents the clinical characteristics of the reported 32 patients with primary pulmonary angiosarcoma.…”

Section: Discussionmentioning

confidence: 83%

Primary Pulmonary Angiosarcoma Presenting with Hemoptysis and Ground-Glass Opacity: A Case Report and Literature Review

Shimabukuro

Yatera

Noguchi

et al. 2015

Tohoku J. Exp. Med.

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Angiosarcoma originates from the vascular endothelium and accounts for only 1-2% of all sarcomatous malignancies. The skin is one of the most common primary sites. However, primary pulmonary angiosarcoma is rare, and only 31 cases of primary pulmonary angiosarcoma have been reported. A 79-year-old Japanese female developed bloody sputum, and chest X-ray and chest computed tomography (CT) showed consolidation with ground-glass opacity (GGO) on the right middle and lower lung fields. The bronchoscopic findings demonstrated bleeding from the right B 4 and B 5 , and bronchial arterial embolization was subsequently performed. However, the CT findings demonstrated new pulmonary nodules with GGO in the left lung, and she presented with hemosputum and a progression of anemia. Right hemothorax also occurred, and surgical lung resection was performed to control the bleeding. The pathological analysis of the resected lung revealed the focal growth of atypical alveolar epithelioid-like cells that were positive for CD31 and negative for epithelial membrane antigen, and these atypical cells were replacing the endothelium of the pulmonary artery. Based on these findings, the patient was diagnosed with pulmonary angiosarcoma, which might originate from the endothelium of the pulmonary artery. No abnormal findings were observed except for the pulmonary involvement on systemic CT scanning. However, the patient passed away due to respiratory failure with compression of the brainstem caused by brain metastasis three months after the first visit. Early surgical resection is the important treatment for patients with angiosarcoma. In addition, we review the literature reporting the patients with primary pulmonary angiosarcoma.

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Section: Discussionmentioning

confidence: 83%

Primary Pulmonary Angiosarcoma Presenting with Hemoptysis and Ground-Glass Opacity: A Case Report and Literature Review

Shimabukuro

Yatera

Noguchi

et al. 2015

Tohoku J. Exp. Med.

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“…8 Different therapeutic modalities have been attempted, but none of them have shown to change the course of the disease. 1,5,11,12 The few reported primary pulmonary AS all presented with bleeding either as intractable haemoptysis, massive intraparenchymal bleeding or intrapleural haemorrhage. 3 The symptoms are unspecific but described as chest pain, haemoptysis, dyspnoea, cough, and malaise.…”

Section: Discussionmentioning

confidence: 99%

“…3 The symptoms are unspecific but described as chest pain, haemoptysis, dyspnoea, cough, and malaise. 5,7,9,10,12 At the primary operation the priority was to achieve haemostasis that went successful but after seven days we had to do re-thoracotomy in order to achieve haemostasis again. The disease was too widespread in the lung and at the chest wall at that time accordingly curative radical surgery was not an option.…”

Section: Discussionmentioning

confidence: 99%

Hemothorax Caused by Primary Pulmonary Angiosarcoma

Kristensen¹,

Olsen²,

Eckardt³

2015

Pulm Res Respir Med Open J

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“…They are often mistaken for a pulmonary embolism and seemingly supported by radiological findings. [2][3][4][5][6][7] These findings include a ventilation perfusion mismatch in the area of the pulmonary artery obstruction. CT scanning can also yield an imagery disguise and thus what appears to be a mass in the pulmonary artery is often mistaken for a pulmonary embolism.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary artery sarcoma mimicking a pulmonary embolism

2008

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27ordered by his primary physician, showed extension of the clot, accompanied this time by the appearance of lung nodules [ Figure 1]. He was recommended discontinuation of warfarin and to be evaluated in hematology/oncology to rule out a neoplastic process.When seen at our institution, his only complaint was ongoing exertional shortness of breath, with no associated hemoptysis, chest pain, cough, night sweats or loss of consciousness. His review of systems was otherwise non-contributory. On account of the suspicion of a possible neoplastic process, a PET scan was obtained, which revealed increased radiotracer uptake over the area of the presumed pulmonary thrombus, as well as other areas of the right lung, including a lower lobe sub pleural nodule [ Figure 2].During his outpatient evaluation he developed two syncopal episodes, with associated exertional dyspnea and presented to our Emergency Department. His electrocardiogram showed ST elevations in leads V3-V5 along with a small elevation in the troponin I of 0.31 (normal is less than 0.20), indicative of AbstractSarcomas involving the lung are a rare occurrence, often a result of metastatic disease from primary malignancies involving the skin, liver, breast or heart. Primary pulmonary artery sarcomas are rarer still, with limited cases reported world-wide and consequently data regarding treatment modalities are sparse and largely experimental. These tumors are often mistaken for a pulmonary embolism and seemingly supported by radiological fi ndings. Patients will often present without symptom resolution despite therapeutic anticoagulation. The following case illustrates how a soft tissue sarcoma of the pulmonary artery can mimic a pulmonary embolism, thus, resulting in both a diagnostic and therapeutic dilemma. A positron emission tomography scan was an invaluable tool in this case, showing increased radiotracer uptake and placing neoplasm at the top of the differential diagnosis. This ultimately led to a biopsy that was vimentin positive, cytokeratin negative and CD117 negative, thus consistent with soft tissue sarcoma.

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Primary angiosarcoma of the lung

Cited by 46 publications

References 10 publications

Primary Pulmonary Angiosarcoma Presenting with Hemoptysis and Ground-Glass Opacity: A Case Report and Literature Review

Primary Pulmonary Angiosarcoma Presenting with Hemoptysis and Ground-Glass Opacity: A Case Report and Literature Review

Hemothorax Caused by Primary Pulmonary Angiosarcoma

Pulmonary artery sarcoma mimicking a pulmonary embolism

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